OBJECTIVE: To prepare paclitaxel microemulsion using film dispersion method and to evaluate the physicochemical property of it.METHEDS: The prescription was optimized with appearance,particle size and stability of paclitaxel microemulsion as indexes.The pH,appearance,morphology,particle size,stability of paclitaxel microemulsion were detected.The drug-loading rate and encapsulation efficiency were determined by HPLC.RESULTS: The paclitaxel microemulsion was translucent diluted-yellow solution with pH of 4.83 and stable property.Paclitaxel microemulsion droplet in electron microscopy consists of small spherical drops and Gauss distribution.The appearance,pH,drug-loading rate and particle size of microemulsion were stable after diluting with sodium chloride injection and glucose injection.The encapsulated efficiency and drug-loading rate of paclitaxel microemulsion were 97.03% and 3.032 g?L-1.CONCLUSION: The film dispersion method could be applied for the preparation of paclitaxel microemulsion which stable.It could not only solve the problem of its poor solubility but also relief remarkable hypersensitivity.

OBJECTIVE: To study the active fractions from Antipyretic analgesics powder.METHODS:The active fractions were extracted from Antipyretic analgesics powder by supercritical-CO2 fluid extraction technique,separated and purified by molecular distillation(MD) technique.The active fractions were selected with the analgesic effect as index.RESULTS: The active fractions obtained showed remarkable analgesic effect.CONCLUSION: The result serves as a theoretic basis for the development of the active fractions-based new drugs.

With the improvement of MRI equipment performance and the usage of multi-channel high sensitivity coil, the application of the diffusion-weighted imaging (DWI) in the abdomen has been achieved. And the DWI has great significance in the diagnosis and differential diagnosis of renal tumors. In this article we reviewed advantages and limitations of magnetic resonance diffusion weighted imaging technology diagnosis in renal cell carcinoma, and also reviewed the latest research progress of DWI technology in the use of kidney.

While only in minute quantities in the body, trace elements are crucial co-factors and regulators of normal metabolism.Commonly tested elements include calcium, magnesium, iron, zinc, and copper.Imbalance or deficiencies in trace elements can cause growth retardation, malnutrition, immune malfunction and other abnormalities in children.Because these elements are in trace amounts, sensitivity and reproducibility of detection methods are of paramount importance.Different methods for the same element can yield different reference intervals, which, in order to be applied in the clinic, would have to be independently established by individual laboratories.Clearly defined indications and good quality control to ensure accuracy and sensitivity are necessary for the measurement of trace elements to provide objective reference for clinical diagnosis.

As a new emerging infectious virus, 2019 novel coronavirus (2019-nCoV) has been widely popular all over the world since the beginning of 2020. As a special group, children have similarities and differences with adults for coronavirus disease 2019 (COVID-19) in the epidemiology, diagnosis and treatment, curative effect monitoring, prognosis, virus testing methodology, infection and inflammation markers, etc. This paper mainly reviews the characteristics of COVID-19 in children from two aspects: the epidemiological and pathogenic detection characteristics, so as to provide some basis for its diagnosis and treatment.

Objective To summarize the meticulous nursing experience of indwelling urinary catheter between the children with hypospadias during perioperative. Methods 317 cases of indwelling urethral only in the silicone Foley tube, and without other urinary diversion with hypospadias were retrospectively analyzed, summarized the fine points of nursing, including preoperative children with comprehensive risk assessment, standardized preoperative skin preparation and postoperative protective constraint, effective properly fixed catheter keep the urine drainage unobstructed, close observation of urine drainage characteristics, maintain urine collection system tightness, maintain perineal skin clean and improved extubation nursing method, and do a good job after extubation nursing. Results 266 cases were cured with a cure rate of 83.9%(266/317);the incidence of urine leakage in 42 cases, the incidence rate was 13.2%(42/317); 7 cases of urethral stenosis, the incidence rate was 2.2%(7/317); 2 cases of urethral closing, the incidence was 0.6% (2/317), none of the patients had accidental extubation. Conclusions The meticulous nursing has a better effect in hypospadias patients during the perioperative period and it can reduce the incidence of postoperative complications;shorten the time of hospitalization and alleviate the suffering of children;improve the quality of nursing service, which is worthy of clinical application.

Objective To investigate the factors influencing the lipid control success rate among patients with coronary heart disease (CHD).Methods Questionnaire and clinical data reviews were conducted to investigate the general information,disease characteristics and patients controlling blood lipid and by blood biochemical tests were done to detect the lipid levels.The relationships between lipid control success rate and general information,disease characteristics and patients' behaviors were analyzed by chi-square test and logistic regression analysis.Results The blood lipid success rate was only 67.09％ in patients with CHD combined dyslipidemia.The education level,cardiovascular disease risk grading,complications,body mass index,medication compliance and dietary evaluation were the main factors influencing the patients' success in blood lipid control.Conclusion The lipid control success rate can be raised by taking measurements to help patients with CHD and dyslipidemia control weight and increase medication compliance and dietary behavior.

Objective To construct a basic competency framework for advanced practice nurses.Methods A primary index system was formed through literature review and expert consultation,the weight of each index was determined by hierarchy analysis.Results The expert authority coefficient was 0.857,Cronbrach alpha of the total system was 0.937.The index system consisted of 5 first-level items,11 second-level items and 46 third-level items.Conclusions The 62-item competency framework for APN is reliable and valid,which can provide quantified standards for selecting,training and evaluating advanced practice nurses.

Objective To learn the status of core competency of cardiovascular specialist nurses in military hospitals in order to supply evidence to establish contrapuntal training protocol.MethodsThe Competency Inventory for Registered Nurse Scale (by LIU Ming) was distributed to investigate the core competency of 156 registered nurses.The data underwent analysis.Results The overall score of core competency level was (3.17±0.69),the highest mean score was the dimension of legal and ethical practice,and the lowest mean score was the dimension of critical thinking and nursing research apititude.the core competency varied with professional title and staffing.Evident difference existed in different dimensions and total scores.Conclusions The overall core competency is at the upper middle level for cardiovascular specialist nurses.They are competent enough to provide healthcare.The cultivation of nurses' critical thinking and nursing research ability should be strengthened.The nursing administrators should carry out pertinent training for nurses according to their different professional levels.

Objective:To establish the core competency index system for emergency rescue of infectious diseases among military advance nurses, so as to provide a reference for evaluating the core emergency capability of military advanced nursing staff.Methods:The index system of emergency core competence of military advanced nursing staff in the emergency of infectious diseases was preliminarily formulated. Based on the evidence-based theory, the improved Delphi correspondence method was used to issue two rounds of questionnaires to 20 authoritative experts. After sorting out and analyzing, the effective questionnaire was formed, and the weight of each index was calculated by AHP.Results:The recovery rates of the two rounds of expert questionnaire were 100%, and the expert authority coefficients were 0.792 and 0.846, respectively; the Kendall ′s W was close to 1, which was statistically significant ( P < 0.01). Finally, three first-class indicators, 12 second-class indicators and 52 third-class indicators were determined, including knowledge related to the prevention of sudden infectious diseases, professional nursing skills and medical support capacity. Conclusion:The results show that the index content of the core emergency rescue capability system of military advanced nursing staff is centralized, the weight distribution is reasonable and has high practicability, which is conducive to improve the practical technical ability and core emergency ability of the military advanced nursing staff, improve the emergency rescue level of infectious disease emergencies and the overall medical support level of military hospitals