Objective:To investigate the correlation between interleukin-17(IL-17) and non-calcified coronary plaque load in patients with type 2 diabetes mellitus.Methods:From January 2022 to November 2022, 150 patients with type 2 diabetes mellitus in the Fifth Affiliated Hospital of Xinjiang Medical University were retrospectively collected as the observation group, and 150 healthy adults were collected as the healthy control group at the same time. The levels of IL-17 and coronary non-calcified plaque load between the two groups were compared. The correlation between serum IL-17 level and non-calcified plaque load was analyzed by Pearson test. The patients with type 2 diabetes mellitus were followed up for 1 year, the predictive value of IL-17 and coronary non-plaque load on adverse cardiovascular events in type 2 diabetes patients were analyzed by receiver operating characteristic (ROC) curve.Results:The levels of IL-17, fasting blood glucose, body mass index, non-calcified plaque volume, non-calcified plaque load and carotid intima-media thickness in the observation group were higher than those in thehealthy control group: (60.34 ± 15.94) ng/L vs. (36.30 ± 14.29) ng/L, (9.38 ± 1.47) mmol/L vs. (5.98 ± 0.61) mmol/L, (26.85 ± 3.42) kg/m 2 vs. (24.84 ± 3.00) kg/m 2, (165.20 ± 27.37) mm 3 vs. (107.33 ± 36.72) mm 3, (27.82 ± 4.68)% vs. (17.98 ± 6.17)%, (1.40 ± 0.16) mm vs. (1.22 ± 0.16) mm; the left ventricular ejection fraction was lower than that in the normal control group: (56.58 ± 7.73)% vs. (67.07 ± 7.95)%, there were statistical differences ( P<0.05). The results of Pearson test showed that the level of IL-17 were significantly positively correlated with non-calcified plaque volume, non-calcified plaque load and carotid intima-media thickness in type 2 diabetes mellitus patients ( r = 0.161, 0.180 and 0.178, P<0.05). The results of ROC curve analysis showed that the level of IL-17, non-calcified plaque load, and non-calcified plaque volume had high predictive value for adverse cardiovascular events in type 2 diabetes mellitus patients within 1 year, the area under the curve were 0.735(95% CI 0.637 - 0.832, P = 0.001), 0.766 (95% CI 0.636 - 0.896, P<0.001), 0.774(95% CI 0.648 - 0.901, P<0.001). Conclusions:The increase of IL-17 in type 2 diabetes mellitus patients is related to the increase of non-calcified plaque load of coronary arteries, and has a high value in predicting adverse cardiovascular events.

Cardiac Catheterization ; Ductus Arteriosus, Patent ; therapy ; Heart Septal Defects, Atrial ; therapy ; Humans ; Printing, Three-Dimensional ; Vena Cava, Inferior