Objective: To understand epidemiology and associated factors of delay for tuberculosis in schools of Jiaxing, and to provide basis for the strategy of pulmonary tuberculosis prevention and control in schools. Methods: Based on the Tuberculosis Management Information System, the information of school tuberculosis cases in Jiaxing from 2011 to 2020 was collected, and the epidemiological characteristics were analyzed by descriptive epidemiology. Results: A total of 436 student pulmonary tuberculosis patients and 46 teacher pulmonary tuberculosis patients were reported in Jiaxing from 2011 to 2020. The average annual incidence rate in teachers (10.70/100 000) was higher than that in students (6.16/100 000) ( χ 2=13.06， P <0.05). The incidence rate of school pulmonary tuberculosis (6.59/100 000) was lower than that in the whole population (37.91/100 000) ( χ 2=184.63， P ＜ 0.05 ). The school pulmonary tuberculosis patients mainly occurred from March to May, accounted for 11.62%,11.00%,9.96% respectively. The incidence rate of school pulmonary tuberculosis patients in county level was lower than in urban district in 2012, and higher than in urban district in 2017 and 2020( χ 2=4.61，5.72，4.02， P <0.05). Most student pulmonary tuberculosis patients aged from 15 to 19 years old, the percentage was higher in males(90) than in females(75) in students. The reported incidence rate of pulmonary tuberculosis in primary school and junior high school teachers was higher than that in the same students ( χ 2=24.34， 14.87 ， P ＜0.05). Passive case finding including clinical symptomatic inspection and referrals was the main way to find cases. The detection delay rate was 34.23%. Conclusion Early detection, prompt and scientific treatment, shortening the delay time were key to prevent the spread of the school tuberculosis. It is of great significance to reduce the occurrence of clustering in outbreak and public health emergency.

Objective:To analyze the expression and clinical significance of serum retinol binding protein 4 (RBP4), superoxide dismutase (SOD) and hypersensitive C-reactive protein (hs-CRP) in patients with acute ST-segment elevated myocardial infarction (STEMI).Methods:Seventy-eight patients with STEMI who underwent percutaneous coronary intervention (PCI) admitted to Nanxishan Hospital of Guangxi Zhuang Autonomous Region from January 2017 to March 2019 were enrolled. On the basis of the routine treatment, atorvastatin calcium or rosuvastatin calcium treatment was given. According to the results of coronary angiography, the patients were divided into three groups: single-vessel, double-vessel and three-vessel lesions, and the severity of coronary artery disease score (SYNTAX score) was performed. The serum RBP4, SOD and hs-CRP were measured and compared among different groups before and after treatment. The correlation between the three serum parameters of STEMI patients and the SYNTAX score, risk prediction (STEMI high-risk score) and prognosis were recorded and compared among different groups.Results:There was no significant difference in serum RBP4, SOD and hs-CRP among different groups before treatment. In multivessel (double-vessel and three-vessel) vascular disease group, SYNTAX score was significantly correlated with RBP4 and hs-CRP (double-vessel lesions: r values were 0.616 and 0.489 respectively, three-vessel lesions: r values were 0.423 and 0.357 respectively, all P < 0.05), but had no correlation with SOD ( r values were 0.108 and 0.055 respectively, both P > 0.05), and high-risk score was closely correlated with RBP4 and hs-CRP levels ( r values were 0.581 and 0.623 respectively, both P < 0.01). There was no significant difference in the prognosis of patients treated with different statins. There were 8 and 7 high-risk patients in the atorvastatin calcium group and rosuvastatin calcium group, respectively, and 2 and 3 dead patients respectively (both P > 0.05). Conclusion:Combined detection of serum RBP4, SOD and hs-CRP levels can be used as better indicators to predict the risk of STEMI, which is worthy of clinical application.

Objective:To evaluate the effect of ionizing radiation on chromosome aberration of peripheral blood lymphocytes in children with vascular interventional procedure.Methods:The chromosome aberration of peripheral blood lymphocytes was analyzed before and after vascular interventional procedure to assess the effect of low-dose ionizing radiation on chromosomes. Peripheral blood (PB) was collected using heparin as an anticoagulant from 26 patients before and after (within 10 minutes) vascular interventional surgery. Informed consent was obtained from the patients′ parents.Results:Dicentric + centric ring (dic+ r) formation increased significantly ( U=647, P<0.01) in peripheral blood lymphocytes of children after interventional operation. No correlation was observed between the rate of dic+ r and the cumulative dose (CD), dose area product (DAP), age, body weight, gender and the estimated effective dose E ( P>0.05). There was no significant difference in dic+ r rate of children between different genders, ages and lesion sites ( P>0.05). The dic+ r rate after interventional operation exceeded 40×10 -3 in 4 of 26 cases with the highest of 95.83×10 -3. Conclusions:The ionizing radiation during children′s vascular interventional procedure might lead to the increase of chromosome aberration of peripheral blood lymphocytes and some children are abnormally sensitive. Great attention should be paid to the justification and radiation protection during interventional procedure for children.