We found that the platelet aggregation rates induced by ADP, arachidonic acid (AA), collagen and A23187 had an apparent decreasing after injection of berberine into the vein of rabbits, and also found that berberine had an apparent inhibition of calcium influx into platelet induced by A23187 at lower concentrations. We demonstrated that berberine had no obvious effect on cAMP level in the intact platelet of rabbits.

The healing process after skin injury is a dynamic process of interaction between various cells, cytokines, and extracellular matrix. Fibrosis is one of the main ways of skin injury repair. The process of fibrosis involves the regulation of many factors. Studies have shown that nerve regeneration-related protein (NREP) plays a key role in the fibrosis of skin tissue and organs. Based on the mechanism of skin fibrosis, this paper discusses the construction of tertiary structure of NREP, summarizes the effects of NREP and different cells in the skin on skin fibrosis and the research progress of mechanism of NREP in skin fibrosis, thus providing new ideas for the treatment of skin fibrosis diseases.