Laparoscopic pancreaticoduodenectomy (LPD) is technically safe and feasible with advantage of minimally invasive feature, and has become a routine procedure in some minimally invasive pancreatic centers. However, LPD is complicated to be operated and will take a long time to operate proficiently. How to successfully promote LPD application has become a key issue in the new era. This article focuses on the key issues in how to promote LPD application safely in primary hospitals, whether LPD can be used for malignant tumors, and how to cultivate new generation LPD experts.