Objective To evaluate the efficacy and safety of Completely-zero-ray for radiofrequency catheter ablation(RFA)of premature ventricular complexes from right ventricular outflow tract(RVOT-PVC)using a 3-dimensional electroanatomic mapping system with single catheter compared with conventional two-dimensional catheter ablation guided by X-ray. Methods 25 patients with RVOT-PVC undergoing ablation treatment in our hospital between April 2015 and March 2017 were included in the research.13 patients were in the 3-dimensional(3-D)group treated by CARTO 3 molding and mapping and ablation with completely zero X-ray.12 patients were in the 2-dimensional(2-D)group treated by ablation guided by traditional X-ray. Such indexes as mapping time,total fluoroscopy time,total procedure time,discharge times,success rate,and complications of the two groups were compared.Results The two groups have no difference in success rate(91.6% vs 92.3%,P=0.953). Compared with 2-D group,the 3-D group have the significant decrease in mapping time(14.8 ± 4.3 vs 4.5 ± 2.2,P=0.000),total fluoroscopy time(20.0 ± 4.6 vs 0 ± 0,P=0.000),total procedure time(63.8 ± 3.9 vs 54.4 ± 4.6,P=0.000)and discharge times(5.7 ± 2.3 vs 3.4 ± 1.0,P=0.003). Conclusions Compared with traditional X-ray guided ablation, mapping time,operation time,discharge times in 3-D group decreased significantly,and zero fluoroscopy can be avoided.Complete ablation for RVOT-PVC guided by zero X-ray fluoroscopy using the CARTO 3 is safe and effective.