Tocotrienol has showed inhibition effect on a variety of cancer cells. It has different mecha-nisms in different types of cancer cells. Its anticancer effects may be mediated by anti-proliferation,anti-oxida-tion,pro-apoptotic and affecting apoptosis signal pathway. Further study on tocotrienol will provide scientific the-ory for new antitumor drugs and cancer primary prevention.

Objective To observe the clinical efficacy of acupuncture plus ozone injection in treating neuralgia due to acute herpes zoster.Method Sixty patients with neuralgia due to acute herpes zoster were randomized into a treatment group and a control group, 30 cases in each group. The control group was intervened by intravenous injection of Acyclovir, muscular injection of Mecobalamin, and external application of Acyclovir cream. The treatment group was intervened by acupuncture plus zone injection in addition to the treatment given to the control group. The time taken for the blisters to cease, crust, and decrust was observed, as well as the change of Visual Analogue Scale (VAS), and the clinical efficacies were compared between the two groups. Result There were significant inter-group differences in comparing the time for the blisters to cease, crust and decrust (P<0.01, P<0.05). The VAS scores were significantly changed after treatment in both groups (P<0.01). After treatment, the VAS score in the treatment group was significantly different from that in the control group (P<0.01). The total effective rate was 96.7% in the treatment group versus 83.3% in the control group, and the difference was statistically significant (P<0.05).Conclusion Acupuncture plus zone injection is an effective method in treating neuralgia due to acute herpes zoster.

Objective:To examine the relationship of parental rearing,self-concept and personality traits of spring bud classes.Methods:A sample of 113 students,including spring buds' 30,non-spring buds' 30,and middle schools' 43,was tested by NEO-PI-R,CAPI,EMBU and Self-concept scale.Results:①Punishment of father,rejection and denial of mother and parental partiality of control group was higher than those of spring bud classes.②Family self-concept of spring bud classes was higher than that of non-spring bud classes.③Neuroticism of control group was higher than that of spring bud classes,but extraversion,human relationship orientation and flexibility of spring bud classes were higher than those of control group.④Partiality of father had positive correlation to extraversion and face of spring bud class students.Personality,moral and family self-concept had positive correlation to harmonious of spring bud class students.Conclusion:Personality and family self-concept of spring bud class students is greatly affected by parental rearing.

ObjectiveTo investigate the effect of hyperglycemia on calcium load and cyclic AMP content in normal and STZdiabetic rat skeletal muscle.MethodsCalcium load and cyclic AMP content were measured in vivo and in vitro after incubation with 5.6mmol/L and 16.7mmol/L glucose concentration.Atom spectrum absorption assay for calcium and radioimmunoassay for cAMP were employed.ResultsHigh concentration glucose elevated cyclic AMP content and lessened calcium load significantly.Cyclic AMP also elevated in diabetic skeletal muscle incubated with even 5.6mmol/L glucose.Diabetes was necessary for high concentration glucose to elevate cyclic AMP in vitro,because cyclic AMP did not change in normal rat muscle even incubated with 16.7mmol/L glucose.But diabetes discounted the reduction of calcium load induced by 16.7mmol/L glucose.ConclusionThe effects of hyperglycemia on calcium load and cyclic AMP content in skeletal muscle may accord with its antiinsulin action,which may be involved in the mechanism of glucose toxicity.

Buprenorphine,one kind of new drugs,is abused in recent years.In this review,some determination and extraction methods for buprenorphine are introduced.The relative merits of liquid-liquid extraction,solid phase extraction,hydrolysis and derivatization methods are compared.The analytical methods such as TLC,GC,GC/MS and LC,LC/MS are discussed.

Objective To investigate the clinical applicative of short 5 Fr pancreatic duct (PD) stents in difficult biliary cannulation of ERCP. Methods 131 patients who underwent difficult biliary cannulation during routine ERCP were randomized to receive prophylactic short 5 Fr PD stents (stent group, 66 patients) and not (control group, 65 patients) from January 2012 to October 2015. The success rate of biliary cannulation for the first ERCP, scores of abdominal pain, the incidence of post-ERCP pancreatitis (PEP) and hyperamylasemia and severe post-ERCP pancreatitis were analyzed. Results The success rate of biliary cannulation for the first ERCP was significantly higher with the stent group than the control group. The scores of abdominal pain of the stent group was significantly lower than the control group. The postoperative serum amylase value at 3 h and 24 h were obviously lower in PD stents group than those in control group. The incidence of hyperamylasemia, post-ERCP pancreatitis, severe post-ERCP pancreatitis were also significantly lower with PD stents group than the control group. 3 cm long 5 Fr PD stents has high success rate of placement, high spontaneous migration rate, low complications, decreases the need for endoscopic removal. Conclusion In difficult biliary cannulation during ERCP, placement of short 5 Fr PD stent is safe and effective, enhance the success rate of biliary cannulation, relieve the abdominal pain, reduces the rate of post-ERCP pancreatitis efficiently.

Objective: To examine the relationship between parental rearing and adolescent personality traits. Methods: A sample of 637 adolescents was tested by CAPI and EMBU. Results: Neuroticism of girls is higher than that of boys, but interpersonal harmony, face and defensiveness of boys is higher than those of girls. Extraversion, openness and agreeableness of only child is higher than those of other adolescents. Most correlations between parental rearing and Adolescent personality traits are significant. Parental warmth and understanding have positive effect on adolescent extraversion, agreeableness and conscientiousness, and father punishment and mother refusal have negative effect on adolescent agreeableness and interpersonal relationship. Conclusion: Adolescent personality is greatly affected by parental rearing.

AIM: To observe the effect of glucosidorum tr ipterygii tororum (GTT) on cytokine productions in acute graft-versus-host disea se (aGVHD) mice. METHODS : C 57 BL/6 mice were exposed to radiation delivered by a linear accelerator . To es tablish a aGVHD model, the cell suspensions, which were obtained from bone marro w and spleen of the BALB/C mice, were transplanted to the radiated C 57 BL/6 mice. The recipients were treated with GTT, GTT+CsA and CsA+MTX. The serum conc entrations of IL-2, TNF-?, IL-4 and IL-10 were determined by ELISA. RES ULTS: The survival rate on day 11 in GTT group (9/10) was higher than in allogeneic bone marrow transplatation (allo-BMT) group (8/19). The concentratio ns of IL-2 and TNF-? in GTT group were significantly lower, but the concentrati on of IL-10 was remarkably higher than that in allo-BMT group ( P 0 0 5). CONCLUSION: GTT inhibited aGVHD development by regulating th e production of cytokines in the host.

Objective To investigate the therapeutic effects of rhein on experimental diabetic nephropathy in rats. Methods Rat model of diabetic mellitus was established by interperitoneal injection of streptozotocin (50 mg/kg) . Renal damages and changes of endothelin (ET) in urine and renal tissues were observed at 12 weeks after the induction of diabetic mellitus and after treatment with rhein (70 mg/kg). Results Compared with the normal rats, at 12 weeks after hyperglycemia, diabetic rats had decreased renal weight/body weight(RW/BW), significantly increased mean glomerular plane area (MGPA), mean glomerular volume (MGV), creatinine clearance rate (Ccr), blood urea nitrogen (BUN), and 24 hour urinary protein excretion (UPE) ( P

Objective To explore the significance and the ultrastructural changes of platelets in patients with acute cerebral infarction.Methods Changes of platelets in 20 patients with acute cerebral infarction were observed by transmission electron microscope.Results The ultrastructural changes of platelets within 24 hours after the onset were significant,including more pseudopodium,aggregation and fusion;there were remarkable fewer alpha granules and mitochondria,the remain of mitochondria swelled and more disruption of platelet membrance were found.The degree of platelet changes consisted with the severity and sizes of cerebral infarction.The ultrastructural change of platelets was obviously restored after 2 weeks,but no restoration was found in 3 patients with large area infarction.Conclusion Ultrastructural changes of platelets in acute period of cerebral infarction were remarkable,especially a lack of alpha granules,this might be regarded as an objective index in the judgment of severity and prognosis of cerebral infarction.