Objective:To explore the correlation between positive psychological capital and quality of life in patients with diabetic retinopathy, and to provide a reference for the development of targeted nursing measures to improve the quality of life of patients.Methods:A total of 226 patients with diabetic retinopathy who were hospitalized in the Department of Ophthalmology and Endocrinology of the First Affiliated Hospital of China Medical University from May to December in 2019 were selected by convenient sampling. The data were investigated by general data questionnaire, positive psychological capital questionnaire for patients with diabetic retinopathy, and National Eye Institute 25-Item Visual Function Questionnaire.Results:The positive psychological capital score of patients with diabetic retinopathy was (72.08±9.42) points; the quality of life score was (52.10±18.22) points; positive psychological capital was positively correlated with quality of life ( r value was 0.571, P<0.01). Conclusions:The positive psychological capital of patients with diabetic retinopathy is positively related to the quality of life. Nursing staff should take measures to improve the level of positive psychological capital of patients, promote their mental health, and improve their quality of life.

Objective:To develop a positive and effective questionnaire for positive psychological capital of patients with diabetic retinopathy, and provide a reference for evaluating positive psychological capital of patients with diabetic retinopathy.Methods:By reviewed the literature, the item pool was constructed based on the definition of the operational definition of positive psychological capital in patients with diabetic retinopathy, and an initial questionnaire was formed. Experts were invited to test the content validity of the questionnaire, and the structural validity, criterion-related validity, and the internal consistency of the questionnaire were tested by surveying 208 patients admitted to the First Hospital of China Medical University.Results:Finally Positive Psychological Capital Questionnaire for Diabetic Retinopathy Patients consisted of 18 items in 4 dimensions. Factor analysis extracted four factors of resilience, self-efficacy, hope and optimism, and the cumulative contribution rate was 55.448%. The correlation coefficient between this questionnaire and the positive psychological capital questionnaire was 0.704 ( P<0.05). The content validity index of the questionnaire was 0.94, the total Cronbach α coefficient was 0.835, and the split-half coefficient was 0.864. Conclusions:The positive psychological capital questionnaire for patients with diabetic retinopathy has good reliability and validity and can be used as a tool to measure the positive psychological capital level of patients with diabetic retinopathy.

Objective: To evaluate the role of spinal COX-1 and COX-2 in remifentanil-induced hyperalgesia in mice with incisional pain. Methods: Thirty-two male C57BL/6J mice, aged 8-10 weeks, weighing 20-25 g, were divided into 4 groups (n=8 each) using a random number table method: control group (group C), incisional pain plus remifentanil group (group IR), incisional pain plus remifentanil plus selective COX-1 inhibitor group (group IR+ SC560), and incisional pain plus remifentanil plus selective COX-2 inhibitor group (group IR+ SC236). In IR, IR+ SC560 and IR+ SC236 groups, normal saline 10 μl, SC560 25 μg and SC236 25 μg were intrathecally injected, respectively, 15 min later remifentanil 10 μg/kg was injected via the tail vein for 4 times at 15 min intervals.An incisional pain model was established after the first injection of remifentanil.The mechanical paw withdrawal threshold (MWT) was measured at 24 h before normal saline or remifentanil injection and 3, 6, 24 and 48 h after the last injection (T₀-T₄). The mice were sacrificed after the last measurement of pain threshold, and the L_4-6 segments of the spinal cord were removed for determination of the expression of COX-1 and COX-2 (by Western blot) and expression of COX-1 and COX-2 mRNA (by quantitative real-time polymerase chain reaction). Results: Compared with group C, the MWT was significantly decreased, and the expression of COX-2 protein and mRNA was up-regulated in IR, IR+ SC560 and IR+ SC236 groups (P<0.05). Compared with group IR, the MWT was significantly increased in IR+ SC560 and IR+ SC236 groups (P<0.05). There was no significant difference in the MWT at each time point between IR+ SC560 and IR+ SC236 (P>0.05) .There was no significant difference in the expression of COX-2 protein and mRNA among group IR, group IR+ SC560 and group IR+ SC236 (P>0.05). There was no significant difference in the expression of COX-1 protein and mRNA among the four groups (P>0.05). Conclusion Compared with COX-1, spinal COX-2 plays a major role in the pathophysiological mechanism of remifentanil-induced hyperalgesia in mice with incisional pain.