1.The Influence of Catgut Implantation at Acupoint on Insulin Resistance of Simple Obesity
Zhongcheng ZHANG ; Jiali WANG ; Qinling KANG ; Xiuming ZHANG ; Jing WANG
International Journal of Traditional Chinese Medicine 2008;30(2):149-150,159
Objective To study the effect of catgut implantation at acupoint on insulin resistance of simple obesity.Methods All patients were separated into the treatment group(catgut implantation group)and the control group(acupuncture group)with 30 cases in each group.Acupoints of zhongwan,tianshu,qihai,shangjuxu,were selected and needled for 3 months.Such indexes as body weight,waistline,hip circumference,body mass index(BMI),fasting blood glucose(FBG),insulin and insulin resistance(IR) before and after treatment were observed.Results Both groups showed obvious anti-obesity effect to simple obesity,manifested by significant differences(P<0.05)at the indexes of body weight,waistline BMI and appetite before and after treatment.Self-comparison in each group showed such indexes as BFS,insulin and IR were significantly decreased after treatment than those before treatment (P<0.05)There was no significant difference at the above-mentioned indexes between the two groups(P>0.05).Conclusions Catgut implantation at acupoint can reduce fat for simple obesity patients by controlling the level of fasting blood sugar,fasting blood insulin and IR in patients.
2.The correlation between up-regulation of cyclooxygenase-2 expression and hepatocellular carcinoma angiogenesis
Chaohui ZOU ; Zhongyou SHENG ; Binsheng XIAO ; Xiao ZHOU ; Jinahong LOU ; Li ZHANG ; Zhongcheng KANG
Chinese Journal of General Surgery 1993;0(01):-
Objective To explore the correlation between up-regulation of cyclooxygenase-2(COX-2) (expression) and hepatocellular carcinoma(HCC) angiogenesis.Methods The expression of COX-2,vascular endothelial growth factor(VEGF)、basic fibroblast growth factor(bFGF) and angiopoientin-2(Ang-2) were examined in eighty matched sets of HCC specimens using immunohistochemistry and reverse (transcription-polymerase) chain reaction(RT-PCR).Results In HCC,the expression rate of COX-2,VEGF,bFGF and Ang-2 was 75.0%,62.5%,60.0% and 61.25%,respectively.(Immunohistochemical) staining scores of VEGF、bFGF and Ang-2 were 5.98?1.16,4.57?0.26 and(5.87)?0.12,respectively in strongly postive group of COX-2;and were 3.30?0.22,2.61?0.16 and 2.63?0.13,respectively in moderately weak postive group of COX-2.The expression rates of VEGF,(bFGF) and Ang-2 were 100.0%(95/95),94.29%(33/35) and 97.14%(34/35),respectively in strongly postive group of COX-2;and were 60.0%(15/25),60.0%(15/25) and 60.0%(15/25),respectively in moderately weak postive group of COX-2.There was significant difference in HCC(angiogenesis) between the two groups(P
3.Preliminary use of HoloLens glasses in surgery of liver cancer
Lei SHI ; Tao LUO ; Li ZHANG ; Zhongcheng KANG ; Jie CHEN ; Feiyue WU ; Jia LUO
Journal of Central South University(Medical Sciences) 2018;43(5):500-504
Objective:To establish the preoperative three dimensional (3D) model of liver cancer,and to precisely match the preoperative planning with the target organs during the operation.Methods:The 3D model reconstruction based on magnetic resonance data,which was combined with virtual reality technology via HoloLens glasses,was applied in the operation of liver cancer to achieve preoperative 3D modeling and surgical planning,and to directly match it with the operative target organs during operation.Results:The 3D model reconstruction of liver cancer based on magnetic resonance data was completed.The exact match with the target organ was performed during the operation via HoloLens glasses leaded by the 3D model.Conclusion:Magnetic resonance data can be used for the 3D model reconstruction to improve preoperative assessment and accurate match during the operation.
4. Application of independently-designed three-demensional printed navigation templates for hepatectomy in hepatic surgical oncology
Pan CHEN ; Wei XIE ; Jie CHEN ; Feiyue WU ; Zhongcheng KANG ; Lei SHI ; Jia LUO
Chinese Journal of Hepatobiliary Surgery 2019;25(9):641-644
Objective:
To investigate the clinical value of independently-designed three-demensional printed navigation templates for hepatectomy in hepatic surgical oncology.
Methods:
A retrospective study was conducted on 45 patients (including 36 males and 9 females, aged from 40 to 70 years) with hepatocelluar carcinoma treated by hepatoctomy from Department of Hepatobiliary and Intestinal Surgery of Hunan Cancer Hospital from June 2016 to June 2018. These patients were divided into observation group (patients conducted with the 3D navigation-template-aided operation,
5.Progress in the role of ω-3 PUFAs in regulating the genesis and development of colorectal cancer.
Si FENG ; Li ZHANG ; Wei XIE ; Zhongcheng KANG ; Pan CHEN
Journal of Central South University(Medical Sciences) 2019;44(5):588-595
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are a class of bioactive polyunsaturated fatty acids with inhibitory effects on colorectal cancer. Firstly, ω-3 PUFAs can change membrane fluidity and affect cell functions; Secondly, they can affect the activity of important proteins in cell signal transduction pathways and regulate the inflammatory mediators and the functions of immune cells in the tumor microenvironment; Finally, they can change the important molecules in the process of tumor metastasis and inhibit the colorectal cancer via suppressing cell proliferation, promoting apoptosis, enhancing antitumor immunity, and preventing tumor metastasis.
Apoptosis
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Cell Proliferation
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Colorectal Neoplasms
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Fatty Acids, Omega-3
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Humans
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Tumor Microenvironment