Objective To observe the short-term curative effect and toxicity reactions of elemene in combination with three-dimensional conformal radiotherapy for advanced esophageal cancer.Methods A total of 57 patients with advanced esophageal cancer were divided into radiotherapy group (28 cases) and elemene combined with radiotherapy group (29 cases).The control group was given conventional irradiation,and the treatment group received intravenous infusion of elemene on the basis of the control group.Changes of clinical symptoms were recorded.Results The effective rates in the control group and the treatment group were 60.7％ and 75.9％,respectively,when follow-up at the 8th week after radiotherapy (P ＜ 0.05).The patients of 2 groups were generally well tolerated,no grade Ⅳ toxicity occurred.Conclusion The efficacy of elemene combined with threedimensional conformal radiotherapy in the treatment of advanced esophageal cancer is better than radiotherapy alone,and it is safe and effective and had fewer side effects.

Objective To observe the short-term curative effect and toxicity reactions of elemene in combination with three-dimensional conformal radiotherapy for advanced esophageal cancer.Methods A total of 57 patients with advanced esophageal cancer were divided into radiotherapy group (28 cases) and elemene combined with radiotherapy group (29 cases).The control group was given conventional irradiation,and the treatment group received intravenous infusion of elemene on the basis of the control group.Changes of clinical symptoms were recorded.Results The effective rates in the control group and the treatment group were 60.7％ and 75.9％,respectively,when follow-up at the 8th week after radiotherapy (P ＜ 0.05).The patients of 2 groups were generally well tolerated,no grade Ⅳ toxicity occurred.Conclusion The efficacy of elemene combined with threedimensional conformal radiotherapy in the treatment of advanced esophageal cancer is better than radiotherapy alone,and it is safe and effective and had fewer side effects.

Objective:To design and synthesize photosensitizers with different substituents and to identify its physicochemical characteritics and photodynamic effect on tumor cells.Methods:Two kinds of BODIPY photosensitizers BPOI and BPCI were synthesized through condensation reaction between aldehyde and reactive hydrogen of pyrrole,followed with electrophilic substitution reaction.Physicochemical properties were characterized by 1H NMR,FT-IR and UV-visible absorption spectra and fluorescence emission spectra.The ability to produce reactive oxygen species was detected by BPDF and DCFH-DA.Photodynamic therapy effect on rat glioma C6 cells in vitro was determined by MTT method.Results:Two kinds of BODIPY photosensitizers BPOI and BPCI were successfully synthesized with different substituents,which were confirmed by 1H NMR,FT-IR.Both materials had low toxicity and could be readily taken up by tumor cells.The ability of synthesized photosensitizers to produce reactive oxygen species was strongly influenced by solvent polarity when the substituent belongs to electron-donating group,while no effect was found when the substituent belongs to electron-withdrawing group.Conclusion:Photosensitizer BPOI with electron-donating substituent produces reactive oxygen species with a slow rate in a highly polar environment,while the ability to produce reactive oxgen is greatly improved in a low polarity environment,which is expected to be used for environmental-selective photodynamic therapy in tumor cells.

AIM: To evaluate the effect of TDF withdrawal time on changes of serum HBV-M, HBV DNA and ALT level in the mother-to-child blocking of the maternal population. METHODS: A prospective, randomized and controlled study was conducted. The 120 pregnant women with HBV who took TDF during 24 to 28 weeks of gestation were randomly divided into group A (withdrawal at delivery) and group B (withdrawal at 4 weeks postpartum), levels of HBV-M, HBV DNA, and ALT at different times were detected. The results were statistically analyzed by Wilcoxon Rank-sum test and χ