One case of schistosomiasis got drug fever after taking praziquantel.

Objective To find out the quality of brain function electromagnetic adjuvant therapy for neurosis treatment.Methods 100 patients were randomly divided into two groups,study group(50 cases)was treated for brain function by electromagnetic therapy with the drug treatment,and only drug treatment was used for the control group(50 cases).The psychological symptom checklist(SCL-90)and Pittsburgh Sleep Quality Index Scale(PSQI)were used to assess clinical symptoms and sleep quality of the two groups before and after therapy of 30 days,and the scale results were compared.Results After treatment,somatization,interpersonal sensitivity,anxiety,depression,hostility,phobia,obsessive-compulsive disorder,paranoid and psychotic items score of SCL-90 scale of study group was significantly lower than the scale before treatment(all P ＜0.05);after treatment somatization and anxiety item scores of SCL-90 scale of study group were significantly lower than the control group(all P ＜0.05).After treatment PSQI total scale score,sleep latency,sleep continuity,sleep efficiency,the use of sleep medications and sleep disorders of study group were significantly lower than before treatment(all P ＜ 0.01);after treatment PSQI total scale score and all items scores of study group were significantly lower than the control group(all P ＜ 0.05).Conclusion Adjuvant treatment of brain electromagnetic had significant effects of improving sleep quality,relieving anxiety and somatization for neurological patients.

Objective:To observe the efficacy of A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis. Methods:Totally 200 cases of candidal vaginitis were divided into the observation group and the control group with 100 cases in each. The control group was given A clotrimazole creams through vaginal administration, qd, while the observation group was treated by ultrasonic atomization of ozone additionally, qd, 15min per time with five times. The clinical efficacy and the recurrence rate after 6 months of the two groups were compared. Before the treatment and in the first and fourth week after the treatment, vaginal secretion bacterial culture was performed and pH value was detected. Results:The cure rate and the total effective rate of the observa-tion group was 88% and 98%, respectively, which was significantly higher than that of the control group (69% and 82%, respective-ly, P<0. 05). After the 6-month follow-up, the recurrence rate was 1. 0% in the observation group (1/98), which was significantly lower than that in the control group [7. 3%(6/82),P<0. 05]. After the treatment, the vaginal pH value in the observation group was reduced notably and the number of lactobacillus was increased significantly(P<0. 05), while those in the control group were without significant changes (P>0. 05). Conclusion:A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis can improve the therapeutic effect.

Coenzyme Q (CoQ),also known as ubiquinone,is a lipid-soluble quinone compound which exists in biological organis ms widely.The numbers of side chain isoprene of different sources of coenzyme Q are different.Coenzyme Q in humans and mammals are called coenzyme Q10 (CoQ10 ,Q10 ), in that the ubiquinone side chain of humans and mammals are mainly composed of 10 isoprene units.In the mitochondrial respiratory chain,it acts as a mobile electron transporter and is a cofactor of uncoup-ling proteins,which is an essential endogenous substance in the process of cell respiration and metabo-lis m.Moreover,CoQ possesses independent antiapoptosis feature,which regulates the mitochondrial permeability transition pore.Mitochondrion is an important organelle,which is the place for energy stor-age and supply,providing the energy for vital movement.There are various kinds of chemical toxicants in the hu man environ ment,and they can enter into the hu man body through drinking,feeding or breath-ing and then affect cell mitochondria to different degrees.Thus,it is important for preventive medicine to investigate intervention or reduction of the biological da mage of exogenous chemicals′effects on mito-chondria.In this paper,we reviewed the research progress of the role of coenzyme Q in xenobiotics in-duced mitochondrial da mage.

Objective To study the effect of atomized inhalation of pulmicort respules combined with tulobuterol in the treatment of children with wheezing pneumonia and its influence on serum inflammatory factors.Methods 90 children with asthmatic bronchopneumonia were selected,and they were randomly divided into observation group and control group,45 cases in each group.The control group received routine western medicine and atomized inhalation of ambroxol hydrochloride.The observation group was treated with pulmicort respules inhalation combined with tulobuterol paste service on the basis of the control group.After 1 course of treatment,the efficacy was evaluated.The improvement of clinical symptoms,clinical efficacy,serum cytokine level,inflammatory index and adverse reaction were compared between the two groups.Results The disappearance time of clinical signs such as shortness of breath,cough,wheezing and pulmonary rales in the observation group were significantly shorter than those in the control group [(7.58±0.72)d,(8.42±1.33)d,(5.66±0.74)d,(7.76±0.75)d vs.(4.21±0.29)d,(2.59±0.71)d,(3.41±0.69)d,(5.29±0.71)d,P<0.01],and there were statistically significant differences between the two groups(t=29.124,25.940,14.913,16.044,all P<0.05).The total effective rate in the observation group was 93.3%,which was significantly higher than 80.0% in the control group(χ2=5.214,P<0.01).There was no significant difference in the ECP and Eos levels between the two groups before treatment(P>0.05).The ECP and Eos in the peripheral blood of the two groups were significantly lower than those before treatment(t=8.363,4.307,13.431,12.949,all P<0.05).The ECP and Eos of the observation group were significantly lower than those of the control group(t=7.792,5.838,all P<0.05).IL-4,IL-6 and IL-10 in peripheral blood of the two groups before treatment were not significantly different(all P>0.05).After treatment,the levels of IL-4,IL-6 and IL-10 were significantly decreased and the IFN-γ level was significantly higher than before treatment(t=17.216,20.051,17.891,15.417,32.724,26.709,28.112,26.708,all P<0.05).The levels of inflammatory cytokines in the peripheral blood of the observation group were significantly better than those of the control group(t=9.306,4.150,5.117,4.124,all P<0.05).No serious adverse events occurred in the two groups during the treatment.Conclusion Pulmicort respules combined with tulobuterol is effective in the treatment of children with wheezing pneumonia.It can relieve the symptoms of cough and wheezing.The mechanism may be related to the imbalance of Th1/Th2 imbalance and the reduction of airway inflammation.

Objective To improve the level of diagnosis and treatment of uterine scar pregnancy after cesarean section,and has a very important relationship with the quality of life of the patients.At present,the purpose of reducing the rate of cesarean section and improving the level of diagnosis and treatment is to improve the quality of life of patients.Methodsthe drug contact ultrasound,analysis of surgical instrument for gynaecology and obstetrics usage of cesarean section to the hospital,and the diagnosis and treatment of uterine incision scar pregnancy patients were selected from 12 patients were investigated.Drugs containing methotrexate combined with mifepristone and mifepristone combined with trichosanthin etc.The diagnosis and treatment process,given daily doses of methotrexate intramuscular injection depth,mifepristone 50mg,two times a day,and then a B-knowledge,in the monitoring,found after a drug combined with gynaecology and obstetric operation type-B ultrasonic monitoring instrument in diagnosis and treatment of cesarean scar pregnancy after mass occurred in the bain line,and the surrounding the blood supply appeared to reduce and disappear.Blood B-HCG levels decreased.The operation of the instrument and the monitoring of the Qing Dynasty under ultrasound monitoring,after abdominal and vaginal B ultrasound monitoring,to avoid the abortion operation of obstetric and gynecological surgical guide device complications,reduce the occurrence of medical disputes.It also realizes the real-time digital recording and storage of the image during the diagnosis and treatment process.Resultsthe drug treatment and application,strengthen the guidance and application of ultrasound in obstetrics and gynecology surgical instrument,reduce the bleeding of uterine scar after cesarean section pregnancy,reduced complications.Conclusionthrough the follow-up of patient records,and proved that this method to reduce the risk,improve the patients quality of life etc.on the safe and effective.

Objective To compare the clinical effect of different doses of oxycodone on endotracheal intubation during general anesthesia induction period.Methods Ninety-five patients with endotracheal intubation general anesthesia were selected as the research subjects,and the patients were randomly divided into group A,group B and group C.31 patients in group A received intravenous administration of oxycodone 0.20mg/kg,32 patients in group B received intravenous administration of oxycodone 0.25mg/kg,and 32 patients in group C received intravenous administration of oxycodone 0.30mg/kg.The adrenaline,norepinephrine,dopamine concentration,as well as mean arterial pressure and heart rate at different time points were compared among the three groups.Results The mean arterial pressure and heart rate at T0 time point were decreased to varying extent compared with those at T1 time point(t =23.618,7.412;22.928,9.063;32.636,9.422,P =0.000,0.000;0.000,0.000;0.000,0.000).The heart rate,mean arterial pressure at T2,T3 and T4 time points in group A were increased compared with T0 time point (t =13.834,6.506,7.015;17.604,14.796,16.323,P =0.000,0.000,0.000;0.000,0.000,0.000).The adrenaline,norepinephrine and dopamine at T2,T3 and T4 time points in group A were increased compared witb T0 time point (t =121.662,64.533,15.687;31.498,16.933,9.286;39.712,116.049,147.102,P =0.000,0.000,0.000;0.000,0.000,0.000;0.000,0.000,0.000).The heart rate,mean arterial pressure,adrenaline,norepinephrine and dopamine at T2,T3 and T4 time points in group B and group C were decreased significantly compared with those in group A (t =19.586,31.972,16.844,27.087;14.046,14.822,15.377,23.826;7.756,14.396,13.268,23.342,100.573,1 04.010,37.612,38.892,107.377,117.969;56.135,56.757,24.223,25.300,95.057,82.088;22.878,25.731,5.532,5.934,134.763,83.628,P =0.000,0.000,0.000,0.000,0.000,0.000;0.000,0.000,0.000,0.000,0.000,0.000;0.000,0.000,0.000,0.000,0.000,0.000;0.000,0.000,0.000,0.000;0.000,0.000,0.000,0.000;0.000,0.000,0.000,0.000),and the differences were statistically significant (all P ＜ 0.05).Conclusion During the induction of general anesthesia,the appropriate dose of oxycodone in patients with endotracheal intubation was 0.25mg/kg,which could effectively maintain the hemodynamic stability,such as mean arterial pressure,and could reduce the stress response.

Objective To observe the early onset breast cancer ( EOBC) sonographic performance character-istics and explore the diagnostic value of ultrasonography in EOBC .Methods 60 cases EOBC patients younger than 35 years old were seclected as the observation group .Older than 35 years of 50 patients with breast cancer were se-clected as the control group .Two groups were underwent breast color Doppler ultrasound .Results 59 cases in 60 pa-tients with preoperative ultrasound diagnosis of breast cancer ,one case was misdiagnosed as mastitis pseudotumor infil-trating ductal carcinoma ,lobular carcinoma ,ductal carcinoma in ultrasound showed more direct signs ,medullary carci-noma showed more indirect signs .Clumps were main types of breast cancer of the observation group and control group , respectively,accounted for 72.9% and 87.5%,the difference was statistically significant (χ2 =6.293,P<0.05). Two groups of color Doppler richness , lesion shape , boundary definition , without hyperechoic halo , calcification and glitches levy or levy Crab compared were not significant (P>0.05);Compared with the control group ,heterogeneous internal echo,rear attenuation of observation group had significant differences (P<0.05).Foci were observed group EOBC anteroposterior diameter and aspect ratio were significantly lower than that of the control group ,the difference was statistically significant(t =6.720,9.285,all P <0.05);diameter was significantly higher (t =34.962,P <0.05).Conclusion Early-onset breast cancer at diagnosis with color Doppler ultrasound large diameter aspect ratio is small,and the rear common heterogeneous internal echo attenuation less characteristic features ,screening younger women for breast cancer is important .

Objective To investigate the dosimetry and feasibility of target volume reduction in three-dimensional conformal radiotherapy for non-small cell lung cancer(NSCLC).Methods Two differ-ent radiation treatment planning,the conventional conformal planning and the small volume conformal plan-ning,were designed for 32 NSCLC patients.Dose-olume histograms were used to assess the dosimetric dis-parity in target regions and surrounding organs at risk.Results Small volume conformal planning could meet the demand of target dose.The least dose,the maximum dose,and the mean dose at subclinical targets were 50.93 Gy,54.60 Gy and(52.37 ±1.02)Gy,respectively.Comparing with the conventional conformal planning,small volume conformal planning reduced the mean dose of lung,spinal cord and esophagus(P<0.05).Conclusion Small volume conformal planning can meet the dosimetric requirement of target vol-ume for NSCLC and reduce the dose of normal tissues,which is worthy of further clinical study.

OBJECTIVE To investigate the epidemic situation of nonfermentative bacteria in lower respiratory tract infection and guide rational use of antimicrobials.METHODS API system was applied for bacterial identification.K-B disk diffuse method was used in susceptibility testing.WHONET 5.3 software was used for data analysis.Pseudomonas aeruginosa,Acinetobacter baumannii and Stenotrophomonas maltophilia isolates were included in this study.RESULTS Less than 20% of P.aeruginosa isolates were resistant to amikacin,imipenem or cefoperazone/sulbactam.For A.baumannii,the most active compounds tested were imipenem and cefoperazone/sulbactam with resistance rates of 4.8% and 7.3%,respectively.26.6% And 27.4% of A.baumannii isolates were resistant to piperacillin/tazobactam and ticarcillin/clavulanic acid.The resistance rate of S.maltophilia to cefoperazone/sulbactam,ticarcillin/clavulanic acid and piperacillin/tazobactam was 0,2.7% and 10.8%,respectively.CONCLUSIONS The isolation rate of nonfermenters is increasing in the lower respiratory tract infection,and the ways to improve the cure rate are to avert nosocomial infection and choose antimicrobials properly.