Objective To evaluate the effects of carvedilol on the cardiac function and serum leptin lever in the treatment of diabetic cardiomyopathy.Methods 40 patients with diabetic cardiomyopathy were randomly divided into carvedilol group and control group.Two groups were given normal therapy and the carvedilol group added carvedilol.The serum levels of leptin and insulin and the heart ultrasound check were measured before and after six months of therapy.Results After therapy the serum levels of leptin and insulin resistance index [ ( 7.18 ± 2.06 ) μg/L,(2.92 ± 0.62) ] were blower than that before therapy in carvedilol group but not control group.After therapy the value of LVEF and E/A were higher[ (46.9 ± 6.8) ％,( 1.05 ± 0.07) ] and LVMI and LVEDd were lower[ ( 108 ± 6 ) g/ m2,(51.8 ± 5.7)mm ] than that before therapy in carvedilol group but not control group( all P ＜ 0.05 ).Conclusion Carvedilol could decrease the levels of serum leptin in patient with diabetic cardiomyopathy and improve insulin resistance and left entricular function.

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