Deep venous thrombosis in the lower extremities is a very common disease clinically and can greatly affect people in their work and life without proper treatment promptly.The author reviewed the etiology,diagnosis,preventive measures and the synthetic therapies for dealing the deep venous thrombosis in the lower extremities,especially concerning the interventional radiology.

80 male Wistar mice were randomly divided into 8 groups. The effects of the big black Ant preparations (alias Xuanju ) obtained in different ways and their compound preparations in different dosages on the amount of RNA and DNA in the testes of mice were observed. After administration of the preparations for 21 days, the mice were decapitated and the testes were excised and weighed. The RNA and DNA in the testes were isolated andpurified with the method of SDS- phenol and their amounts were measured with UV-VIS spectrophotometry. The results showed that the mean testes weight in the experimental groups was significantly higher than that in the control group (P

Based on ESI web of science,the article analyzed papers published by three Medical Schools from 2001 to 2012 in terms of volume of publication,cited times,discipline distribution,au thors and cooperation,and determined each factor's impact on research output and performance.Sug gestions and advice were given to enhance the overall basic medical science research level.

Humans ; Occupational Diseases ; prevention & control ; Occupational Health Services ; organization & administration ; Risk Assessment ; Workplace

Objective To investigate the effect of head-up tilt on cerebral blood flow velocity during general anesthesia in patients with diabetic neuropathy.Methods Sixty ASA Ⅰ - Ⅱ patients of both sexes aged 40-60 yr weighing 52-70 kg undergoing general anesthesia were divided into 3 groups according to diseases complicated with diabetes situation ( n =20 each):group Ⅰ normal control the patients did not have diabetes mellitus; group Ⅱ type Ⅱ diabetics without neuropathy and group Ⅲ Ⅱ diabetics with neuropathy.Anesthesia was induced with propofol 2 mg/kg,fentanyl 3 μg/kg and vecuronium 0.1 mg/kg and maintained with 1％ sevoflurane.The patients were intubated and mechanically ventilated.PErCO2 was maintained at 35-45 mm Hg.Transcranial doppler (TCD)was used to measure middle cerebral artery blood flow velocity (MBFV).MAP and MBFV were measured and recorded in supine position (baseline) and at 1.5,3.5 and 5.5 min of 45° head-up tilt.Results The 3 groups were comparable with respect to age,body weight,height and M/F sex ratio.MAP and MBFV significantly decreased at 45° head-up tilt as compared with the baseline in all the 3 groups.There was no significant difference in MAP and MBFV among the 3 groups.Conclusion Cerebral blood flow velocity decreases when the patients are tilted 45° head-up during general anesthesia in both diabetics with and without neuropathy,but there is no significant difference between the 2 groups.

Magnetic resonance imaging (MRI), featuring as no ionizing radiation, higher soft tissue resolution and multiplanar imaging, has been widely used in the diagnosis of pediatric tumors. Conventional MRI techniques mainly provide information on morphological information of tumors but cannot display physiological and pathological changes in tumors. In recent years, with rapid development of MRI hardware and software, some functional MRI technologies have been applied in clinical practice and have become an important trend on pediatric oncology. These techniques include perfusion-weighted imaging, diffusion-weighted imaging, magnetic resonance spectroscopy, susceptibility weighted imaging. These new technologies can demonstrate the microstructural information of tumors, which will provide more helpful information for diagnosis, treatment and follow-up in pediatric tumors when combined with conventional MRI techniques.

BACKGROUND: A left-to-right shunting animal model is needed to study chronic pulmonary vascular remodeling of congenital heart attachment disease in adult.OBJECTIVE: To observe the characteristics of chronic pulmonary arterial hypertension in rat models subjected to left-to-right shunting.DESIGN, TIME AND SETTING: Randomized controlled animal modeling observation was performed in Experimental Animal Center, Xinqiao Hospital, the Third Military Medical University of Chinese PLA from April 2008 to April 2009.MATERIALS: A total of 80 male inbred line healthy SD rats of specified-pathogens free class, 4 weeks old, weighing 95-110 g, were randomly assigned into control group (n=40) and shunt operation group (n=40). A shrinking polyethylene blood vessel connector (proximal part inner diameter was 0.6 mm and outer diameter was 0.8 mm, while distal part's was 0.8 mm and 1.0 mm, respectively, 1.6 mm long), was applied.METHODS: Shunt operation group underwent left-to-right shunting through right common carotid artery and external jugular vein connected by shrinking polyethylene blood vessel connector. Control group underwent sham operation. At 4, 8, 12 and 16 weeks postoperation, ten models were determined with a series in procedures: hemodynamics detection, pathological sample preparation, hematoxylin-eosin staining, imaging analysis and so on.MAIN OUTCOME MEASURES: Changes in right ventricular systolic pressure, right ventricular hypertrophy index of right ventricle to left ventricle plus interventricular septum, and relative medial wall thickness in moderate sized pulmonary arteries in rats of shunt group and control group.RESULTS: All animal were survived. The pulmonary blood flow in shunt group was significantly higher than control groups (P<0.01). Compared with control group, right ventricular systolic pressure elevated obviously and right ventricular hypertrophy index were significantly higher in shunt group at 12 and 16 weeks (P<0.01). Compared with control group, the relative medial wall thickness in pulmonary arteries also elevated obviously in shunt group at 12 and 16 weeks (P<0.01).CONCLUSION: Left-to-right continuous low-flow shunt in rats can induced right ventricle accommodated with the change of right ventricular systolic pressure and promote chronic pulmonary arterial remodeling continuously. The procedure of establishing left-to-right shunting models with common carotid artery and external jugular vein connection, is a stable tool for studying chronic pulmonary arterial hypertension induced by low flow.

Currently,the diagnosis of malignant pheochromocytoma still faces a big challenge.Neither biochemical nor histological features can be reliably used to distinguish malignancy from benign tumors.Numerous efforts have been applied to identify novel molecular markers to predict malignancy.

Objective To compare the efficiency of repairing perimembranous ventricular septal defect (VSD) with continuous stitching to that with interrupted stitching. Methods Of the 158 patients with perimembranous VSD ( 54% males) ,102 ( 65% ) patients underwent the repairing of continuous stitching (continuous group) ,and 56 patients underwent interrupted stitching (interrupted group). All the surgeries were performed under hypothermic cardiopulmonary bypass. Results The cardiopulmonary bypass time and aortic cross-clamp times were (31 ±14) mins and (18 ±12) mins in the continuous group, which was significantly less that those of (42 ± 16) mins and (25 ±11) mins in the interrupted group (t =4.49 and 3. 61 .respectively ,P <0. 05) . No case was died. The main complications involved temporary M atrioventricular block (AVB) of two cases (1 case in each group),which disappeared after 1 week. There were two remnants remaining leak (n =2) which was less than 3 mm and automatically cured after 3-6 months. Complete right bundle branch block(CRBBB) occurred in 3 cases in the continuous group and 6 cases in the interrupted group,of which 3 disappeared after 1 month and 2 disappeared after 12 months. The outcome was good in all cases after 1-3 years follow up. Conclusions Continuous stitching showed a shorter cardiopulmonary bypass and aortic cross-clamp times, and reduced the CRBBB.

OBJECTIVE:To evaluate therapuetic efficacy and toxic reaction of 2 therapuetic regimens for 56 cases of bone me-tastasis of cervical cancer. METHODS:56 cases of bone metastasis of cervical cancer with complete information were collected ret-rospectively and randomly divided into radiochemotherapy group(31 cases)and diphosphonate group(25 cases). Radiochemothera-py group was given radiotherapy,chemotherapy and diphosphonate;diphosphonate group was given palliative symptomatic treat-ment of diphosphonate;a treatment course lasted for 3-4 weeks,and both groups received 3 courses of treatment. Average survival time,survival quality and toxic reaction were comparison in 2 groups. RESULTS:After bone metastasis of cervical cancer,the av-erage survival time of radiochemotherapy group was 17 months (95%CI:9.1-24.9),and that of diphosphonate group was 19 months (95%CI:2.4-35.6);3 years later,the survival rate of radiochemotherapy group was 16.1%,and that of diphosphonate group was 16.0%,there was no statistical significance(P=0.820). To compared KPS after 3 treatment courses,the improvement rate of radiochemotherapy group(22.6%)was significantly lower than that of diphosphonate group(40.0%),with statistical signif-icance (χ2=4.36,P<0.05). Toxic reaction of radiochemotherapy group was more significant than that of diphosphonate group. CONCLUSIONS:Diphosphonate has little effect on survial quality and slight toxic reaction. It is worthy of spreading in some pa-tients with advanced,elderly and reccurred bone metastasis of cervical cancer.