Objective: To analyze the risk factors and the predictive value of LDL/HDL ratio in acute ischemic stroke recurrence.
Methods: A total of 143 patients with acute ischemic stroke treated in our hospital were studied. The patients were followed-up for 2 years, the risk factors and the predictive value of LDL/HDL ratio for stroke recurrence were analyzed.
Results: Single factor analysis indicated that lacunar infarction, hypertension, blood pressure, the levels of LDL, HDL, ratio of LDL/HDL, stroke scale score, life ability score were the risk factors of ischemic stroke recurrence. Multivariate analysis presented that hypertension, ratio of LDL/HDL, TG level were the independent risk factors for ischemic stroke recurrence. LDL and ratio of LDL/HDL were positively related to ischemic stroke recurrence, HDL was negatively related to ischemic stroke recurrence, P<0.05. The speciifcity and sensitivity of LDL/HDL for predicting ischemic stroke recurrence were at 81.16%and 95.65%respectively.
Conclusion: The predictive value of LDL/HDL ratio could help us to identify the patients with high risk of ischemic stroke recurrence which is important for the early clinical intervention.

Mesenchymal stem cells(MSCs) have became the hot spot in cell tissue engineering,cell replacement therapy,gene therapy and transplant research fields. Recent studies have shown that changes in oxygen concentrations affect many biological characteristics of MSCs. Under different oxygen concentrations,MSCs have different proliferation,differentiation,migration and chemotoxis abilities. Hypoxia is a kind of common pathophysiological status,which can promote the proliferation,apoptosis,migration and chemotoxis abilities of MSCs,while hypoxia impacts the differentiation ability depending on different cell types. The mechanism of these response might be involved in hypoxia-inducible factor-1(HIF-1) ,chemokines and their receptors,and matrix metalproteinases. Hypoxia can activate HIF-1 signaling pathway,which upgrades the expression of stromal-derived factor-1(SDF-1) ,and forms microenvironments which stem cells are adapted to and grow in. SDF-1 increases the adhesion,migration and homing of circulating CXCR4-positive progenitor cells to ischemic tissue,and promotes degradation of extracellular matrix,then enhances the migration ability of MSCs by modulating the expression of matrix metalloproteinase and its protein as well.

Several signaling pathways are involved in clonal proliferation of lymphoma cells and disease progression. It has been shown that cyclic adenosine monophosphate (cAMP) signaling pathway, as an important intra-cellular messenger delivery system, is related to modulation of multiple physiological processes including cell prolifer-ation, secretion, metabolism and apoptosis. Manipulating the cAMP signaling pathway can induce cell cycle arrest and apoptosis of various malignant lymphoid cells, which involves mitochondria-dependent apoptosis and cAMP-modulated protein kinases as well as changes of intracellular mediators. In-depth research and analysis of cAMP-induced apoptosis in lymphoma cells would provide potential targets and possible therapeutic means for the treatment of lymphoma.

Cerebellar Neoplasms ; genetics ; Chromosome Aberrations ; Genes, myc ; Genes, p16 ; Genes, p53 ; Humans ; Medulloblastoma ; genetics ; Mutation ; Neuroectodermal Tumors, Primitive ; genetics ; Supratentorial Neoplasms ; genetics

Objective To identify the risk factors for postoperative reintubation in patients undergoing general anesthesia.Methods Forty-six thousand five hundred and seven patients,aged 18-83 yr,requiring reintubation after planned extubation in the postanesthesia care unit (PACU) of our hospital from January 2010 to December 2012,served as reintubation group.Patients in a 1∶5 ratio,aged 18-83 yr,admitted to the PACU of our hospital from January 2010 to December 2012,with successful extubation,served as control group.The general data of patients and operation-related factors including type of operation (emergency operation/elective operation),operative sites (head and neck,airway,within the chest,upper abdomen,lower abdomen,other sites) and operation time and anesthesia-related factors including requirement for opioids and muscle relaxants within 30 min before operation,and for neostigmine at the end of operation were recorded.The risk factors of which P values were less than 0.05 would enter the logistic regression analysis to stratify reintubation-related risk factors.Results Thirty-two patients were reintubated after operation and the incidence was 0.069％.There was significant difference in age,gender,body mass index,ASA physical status,preoperative SpO2,complication with upper respiratory infections within 2 weeks before operation,chronic obstructive pulmonary disease (COPD),or systemic inflammatory response syndrome (SIRS) and hypoproteinemia,operative sites and operation time between the two groups (P ＜ 0.05 or 0.01).The logistic regression analysis showed that ASA physical status ≥ Ⅲ,complication with COPD or SIRS,and thoracic surgery were closely correlated with postoperative reintubation in patients undergoing general anesthesia.Conclusion ASA physical status ≥ Ⅲ,complication with COPD or SIRS,and thoracic surgery are risk factors for postoperative reintubation in patients undergoing general anesthesia.

Tropical medicine is defined by an association with geographic location, and it is a branch of medicine integrating preclinical medicine, clinical medicine and preventive medicine and investigating the diagnosis, treatment and prevention of diseases of tropical and subtropical zones. Military tropical medicine is a new interdiscipline based on tropical medicine and military medicine. With the improvement of health condition and the development of global economy, some tropical infectious diseases have been gradually controlled. However, factors such as increasingly frequent international communication and extreme changes in global climate induced by overproduction activity of human are leading to a redistribution of infectious diseases, which inevitably has impact on military strategies and tactics. This article reviews the past and prospect of military tropical medicine.

Epidemic diseases often occur following natural disasters, such as earthquakes. The most commonly seen epidemics after an earthquake include: enteric diseases (dysentery, typoid and paratypoid fever, cholera, hand foot-mouth disease, hepatitis A, hepatitis E, etc), arthropod-borne infectious diseases (malaria, Kala-Azar, Japanese encephalitis, etc), zoonosis (plague, hemorrhagic fever with renal syndrome, anthrax, etc), soil and epidemic water transmitted diseases (tetanus, gas gangrene, leptospirosis, etc), respiratory diseases (measles, rubella, influenza, etc), food-borne diseases (food poisoning caused by bacteria or bacterial toxin). This article reviews the controlling principles and measures for major infectious pathogens and epidemic diseases after earthquake.

Objective To investigate the clinical pathology characteristics of the p27 and C-myc protein expression in lung squamous cell carcinoma and adenecarcinoma as well as the correlation between the expressions of them. Method The expressions of p27 and C-mye protein in tumor tissue of 35 cases excised during pulmonectomy for lung squamous cell carcinoma and adenocarcinoma patients were examined using immunochemical method,and compared with 10 cases of normal lung tissue. Results The total positive rate of p27 protein was 17.1%(6/35 ) in 35 eases of tumor tissue, but 90.0%(9/10) in normal lung tissue, and there was significant difference (P< 0.05 ). Between high-moderate and low differentiated tissue,the positive rate had significant difference (P = 0.005). There was no significant difference of p27 protein expression in patients with different tumor size and histology types, as well as with or without lymph nodes metastasis (P > 0.05 ). The total positive rate of C-myc protein was 85.7% (30/35) in tumor tissue, but no expression existed in normal lung tissue (P < 0.05). There was significant difference of C-myc expressions between the tissue with and without lymph nodes metastasis (P =0.013),but there was no significant difference in various tumor size, differentiated degree, as well as histology type(P> 0.05). The expression of p27 and C-myc in lung squamous cell carcinoma and adenecareinoma showed negative correlation.Conclusions The expression of p27 protein is positive in normal lung tissue, but shows outstanding decrease in lung squamous cell carcinoma and adenocarcinoma tissue. Its expression correlates with the differentiated degree. The expression of C-myc is negative in normal lung tissue but shows significant increase in lung squamous cell carcinoma and adenocareinoma tissue and its expression correlates with lymph nodes metastasis. C-myc may be a valuable marker in evaluating prognosis.

Objective:To explore the influence of infusion drop speed on the efficacy of tiopronin for injection combined with sol-vents in the treatment of abnormal liver function. Methods:Totally 74 patients were randomly divided into the observation group and the control group with 37 ones in each. The infusion drop speed was 60-65 drops per minute in the observation group, and that was 30-35 drops per minute in the control group, and the infusion time was controlled in 1h in the observation group and 2h in the control group. The clinical effect and the improvement of liver function were compared between the two groups after a treatment course of 4 weeks. Results:The total effective rate of the observation group(83. 78%) was obviously higher than that in the control group(56. 76%) (P<0. 05) after the treatment, and ALT, AST and TBIL of liver function indices were improved obviously except for ALB in the two group, and the difference was statistically significant between the two groups(P<0. 05). Conclusion:Tiopronin for injection can effectively improve the clinical effect by strictly controlling the time and drop speed of infusion.

Objective To define the characteristic values of the pharyngeal cavity by comparing the values of measures and ratios between the patients with obstructive sheep apnea-hypopnea syndrome(OSAS) and controls.Methods Sixty-eight OSAS patients who were diagnosed using polysomnography,and 56 healthy people were scanned by MSCT(multiple slices computed tomography)in the awake state.Then, the values were measured on the reformated images and were compared between two groups.Results Of the 63 values,49 values were different between the two groups,and among those,4 values were entered into the Discriminant Functions.These were the left-right diameter(LR)[OSAS:LR=(9.4?3.7)mm,controls: LR=(20.1?5.0)mm,t=-13.820,P=0.000)and the cross-sectional area(XSA)[OSAS:XSA= (54?27)mm~2,controls:XSA=(164?77)mm~2,t=-10.944,P=0.000]of RP,the heights of tongue [OSAS:(75.4?8.3)mm,controls:(58.4?9.8)mm,t=10.476,P=0.000],the lengths of uvula/the lengths of airway(OSAS:0.139?0.039,controls:0.154?0.048,t=-1.983,P=0.050).Conclusions Many measures and ratios were different between the two groups,but there were overlaps between them. Measures using the Discriminant Functions can help the diagnosis of OSAS.