Objective To observe the clinical effects of treating chronic type B hepatitis with Gankang Granule combined with poly I-C and immune ribonucleic acid. Methods A total of 100 cases of chronic type B hepatitis were randomly recruited into a control group and a treatment group, 50 cases in each group. The control group was treated with poly I-C and immune ribonucleic acid, while the treatment group was treated with Gankang Granule on the basis of the control group. Results Symptoms in both groups were improved. 23 eases in the treatment group showed negative value of HBeAg,contrasting to 13 cases in the control group. 38 cases in the treatment group turned to be negative value of HBV- DNA, higher than the number of 23 cases in the control group. The treatment group demonstrated a significantly better therapeutic results than the control group (χ2 value was 6.267 and 6.345 respectively, both P＜0.05). Conclusion Gankang Granule combined with poly I-C and immune ribonucleic acid can obviously improve hepatic functions and symptoms of chronic type B hepatitis,shorten the course of disease, and increase the rate of negative value of HBeAg and HBV- DNA.

Acupuncture Points ; Acupuncture Therapy ; instrumentation ; methods ; Child ; Child, Preschool ; Enuresis ; physiopathology ; therapy ; Female ; Humans ; Male ; Treatment Outcome

BACKGROUND:Studies have shown that emodin protects against intestinal ischemia-reperfusion injury by inhibiting the release of inflammatory factors. OBJECTIVE:To investigate the effect of emodin on renal ischemia/reperfusion injury after bone marrow mesenchymal stem cel transplantation. METHODS:Forty Sprague-Dawley rats were randomized into five groups (n=8 per group):sham group, model group (renal ischemia/reperfusion injury group), bone marrow mesenchymal stem cel group (cel transplantation group), low-dose emodin group, high-dose emodin group. Rats in the latter four groups were pretreated with or without different concentrations (30 and 60 mg/kg) of emodin for 7 days, and then were subjected to clamping bilateral renal pedicles for 45 minutes, fol owed by injection of 1 mL bone marrow mesenchymal stem cel suspension. Six hours after reperfusion, the pathological changes of renal tissues were examined by hematoxylin-eosin staining;the mRNA levels of tumor necrosis factorα, interleukin-6, interleukin-18, TLR2 and TLR4 detected by real-time fluorescence quantitative PCR;and the protein expression of COX-2, ICAM-1 and iNOS determined by western blot. RESULTS AND CONCLUSION:Compared with the sham group, rats in the model group showed obvious features of severe acute tubular damage and inflammatory cel infiltration. In the cel transplantation group, tubular epitheliael cel s were partial y lost with some inflammatory cel s infiltrated in the renal interstitium. In the emodin groups, the tubular lumen was practical y intact with little renal interstitial inflammatory cel s. Compared with the sham group, a significant increase in the mRNA levels of tumor necrosis factorα, interleukin-6, interleukin-18, TLR2 and TLR4 as wel as in the protein levels of COX-2, ICAM-1 and iNOS was found in the model group (both P<0.05). However, bone marrow mesenchymal stem cel transplantation attenuated this ischemia/reperfusion-induced increase in the expression of the above-mentioned factors (P<0.05). Furthermore, the effects of bone marrow mesenchymal stem cel transplantation were further augmented by pretreatment with emodin in a dose-dependent manner. These findings suggest that emodin can enhance the protective effects of bone marrow mesenchymal stem cel s on renal ischemia/reperfusion injury.

Objective To study the effect of treating fatty liever with Tiaozhisugan decoction combined with simvastatin. Methods A total of 60 cases with fatty liver were randomly recruited into a control group and a treatment group.The control group was treated with simvastatin, vitamin E, and pioglitazone, while the treatment group was additionally treated with Tiaozhisugan decoction on that basis. Results The total effective rate was 93.9% and 79.6% in the treatment group and the control group respectively, the difference showing statistical difference (χ2=2.586, P＜0.01 ) .Conclusion It was effective to treat fatty liver with Tiaozhisugan decoction combined with simvastatin.

Adult ; Female ; Foreign Bodies ; surgery ; Humans ; Neck ; Oropharynx ; surgery

Fluid Therapy ; Humans ; Rehydration Solutions

Objective To investigate the prevalence of chronic kidney disease (CKD) in patients with acute stroke and the risk factors and prognostic characteristics in these patients.Methods A total of 270 consecutive hospitalized patients with acute stroke was recruited, and their CKD was evaluated transversally. Various risk factors and short-term prognosis of 53 patients with CKD whose National Institutes of Health Stroke Scale (NIHSS) scores were similar at admission among the 270 patients with stroke were compared to those of 106 patients without CKD. CKD was defined as glomerular filtration rate (GFR) ＜ 60 ml/(min·1.73 m2) and (or) random urinary albumin-to-creatinine ratios (ACR) ＞ 30 mg/g, and continued for more than 3 months. GFR was estimated according to the simplified Modification of Diet in Renal Disease (MDRD) equation, The modified Rankin Scale (mRS) was used to evaluate the shortterm prognosis. Results The prevalence of CKD in these patients was 19.6%, and most of them were early-and middle-stage CKD. The proportions of the histories of hypertension (81.13%), diabetes mellitus (33.96%), and stroke (45.28%) in patients with CKD were significantly higher than those in patients without CKD (64.15%, 18.86% and 27.36%,respectively, all P＜0.05). The mean levels of systolic pressure (151.74±20.98 mm Hg) and low density lipoprotein (3.03±0.96 mmol/L) in patients with CKD were significantly higher than those in patients without CKD (systolic pressure was 144.44±21.13 mm Hg, and low density lipoprotein was 2.75±0.76 mmol/L, all P＜0.05). In addition, the levels of erythrocytes sedimentation rate(median, 39 mm/h), high sensitive C-reactive protein (median,5.12 mg/L) and parathyroid hormone (81.01±26.78 pg/ml) were significantly higher than those in patients without CKD (they were 20 mm/h, 3.36 mg/L, and 46.95±24.63 pg/ml,respectively, all P＜0.05). There was a changing trend in low serum calcium and high serum phosphorus in patients with CKD. The proportion of the patients whose mRS score ≥ 3 at 3 months after the onset in patients with CKD was significantly higher than that in patients without CKD (66.03% vs 46.23%, P＜0.05). The mortality at 3 months (9.43%) also had an increasing tendency (P=0.073). Conclusions The prevalence of CKD was higher among the stroke population, and most of them were early-and middle-stage CKD. The stroke patients with CKD had more risk factors and worse prognosis than those without.

Objective To assess the reliability and validity of standardized facial photographs under natural head position (NHP) in assessment of mandibular asymmetry cases. Methods Standardized facial photographs (SFP) and posteroanterior cephalometry (PAC) were taken under natural head position from 25 mandibular asymmetry eases (14 boys and 11 girls), aged 14 to 29 years old. Distances from 8 landmarks to the vertical reference line were measured. The difference and the asymmetry ratio of two sides were calculated respectively. The relationship between the measurements of SFP and PAC were compared, and the repeatability of landmarks was assessed. Results Six measurements were significant different between two sides, 3 from SFP and 3 from PAC. Measurements from two ways were correlated a cer-tain extent. The repeatability of landmarks was satisfied. Conclusion Measurements from standardized facial photographs under NHP pres-ent a clinical useful method to quantify mandibular asymmetry.

Lennox-Gastaut syndrome ( LGS) is an globally recognized refractory epilepsy,also known as an age-dependent epileptic encephalopathy. It is characterized by multiple seizure types, mental retardation, and slow spike-wave complexes discharges or fast rhythmic bursts during sleep on electroencephalographic re-cordings. Many antiepileptic drugs were reported for the treatment of LGS,but it was difficult to compare their efficacy because of the small sample size and design limitations. Valproate,topiramate and lamotrigine are rec-ommended to be the first-line drugs by most guidelines or expert consensus,and the combination of valproate and lamotrigine or the combination of lamotrigine and topiramate should be preferred as early as possible for initial treatment of LGS in children. Recent progresses of medical treatment of LGS are reviewed and some optical re-gimes are proposed in this paper.