Objective Our aim is to compare the safety and benefits of laparoscopic versus open incision hernia repair.Methods Forty-seven patients in our hospital were analyzed with prospective randomized double-blind study following either laparoscopic or open hernia repair.And others prospective randomized studies(PRS)were analyzed.Results Overall complication rate was similar in both groups(8.5% versus 9.2% in the laparoscopic and open groups respectively),but some early complications in the laparoscopic group maybe require a reoperation.Operating time was similar in the laparoscopic group.There was shorter length of stay and higher expense in the laparoscopic group and there was significant difference in the pain scores and medications,resumption of diet,or activity scores.At 2 weeks,there was no difference in the activity or pain scores,but physical function and physical health scores on the short-form 36(SF36)quality of life assessment forms were little in the laparoscopic group.Regardless of the technique(P=0.158).The result of PRS meta-analyses is that operating time was simila in the laparoscopic group.There was longer length of stay in the Laparoscopic group.And the rate of wound infection is significantly higher in the open groups.Conclusion Unlike other minimally invasive procedures,Laparoscopic hernia repair did not offer an advantage over open hernia repair in all studied parameters except pain,activities and quality of life scores at 2 weeks.It also took similar to perform.The choice of the procedure should be based on surgeon or patient preference.

Objective To explore the clinical effect of drug combination psychological intervention in colorectal cancer patients.MethodsRetrospective analysis of 60 cases surgical histopathology diagnosis of colorectal cancer patients with clinical diagnosis and treatment data from January 2014 to January 2016 in the Shaoxing Second Hospital, all patients were treated with surgery, including postoperative chemotherapy, hyperthermia treatment as the control group;In the control group based on supplemented by traditional Chinese medicine Fuzheng Xiao′ai Tang, psychological intervention for the observation group, each group of 30 cases.ResultsThe scores of quality of life and self-care ability of the two groups were significantly higher than those of the control group before and after treatment, and the scores of self-care ability were significantly higher in the observation group than in the control group (P<0.05) The levels of CEA, CA199 and CA242 were significantly lower than those of the control group before and after treatment, the level of tumor markers was significantly lower than that of the control group (P<0.05).The total effective rate was 73.33% in the observation group, which was significantly higher than that in the control group (43.33%, P<0.05).The observation group was significantly higher than the control group (P<0.05) Mental health was significantly lower than the control group,(P<0.05).ConclusionChinese medicine Fuzheng Xiao′ai Tang combined with chemotherapy and psychological intervention in the treatment of colorectal cancer after the effect is significant and safe.

Objective To investigate the clinical characteristics and the risk factors for chronic complications in hospitalized early-onset type 2 diabetic mellitus patients. Methods The clinical data of 462 hospitalized type 2 diabetic mellitus patients were retrospectively analyzed. The patients were divided into early-onset group (age of diagnosis ≤40 years, 120 cases) and late-onset group (age of diagnosis>40 years, 342 cases) according to the age of diagnosis of diabetes. The clinical characteristics were compared and risk factors for chronic complications of early-onset type 2 diabetes were explored. Results The percentage of family history of diabetes, fasting plasma glucose, triglyceride and diastolic blood pressure in early-onset group were significantly higher than those in late-onset group:70.0％(84/120) vs. 52.3％(179/342), (8.68 ± 3.08) mmol/L vs. (8.07 ± 2.74) mmol/L, 1.69 (1.06, 2.92) mmol/L vs. 1.48 (1.07, 2.24) mmol/L and (84 ± 10) mmHg (1 mmHg = 0.133 kPa) vs. (81 ± 10) mmHg, and there were statistical differences (P<0.01 or <0.05). The incidence of hypertension, systolic blood pressure and 2h C-peptide in early-onset group were significantly lower than those in late-onset group: 44.2％(53/120) vs. 60.2％ (206/342), (134 ± 17) mmHg vs. (138 ± 18) mmHg and (3.99 ± 2.47) μg/L vs. (4.75 ± 2.65) μg/L, and there were statistical differences (P<0.01 or < 0.05). There were no statistical differences in smoking percentage, body mass index, glycated hemoglobin, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) between 2 groups (P>0.05). The incidences of peripheral vasculopathy and cerebrovascular disease in early-onset group were significantly lower than those in late-onset group:13.3％(16/120) vs. 24.3％(83/342) and 11.7％(14/120) vs. 22.8％(78/342), but the incidence of diabetic nephropathy was significantly higher than that in late-onset group: 37.5％ (45/120) vs. 27.8％ (95/342), and there were statistical differences (P<0.05 or <0.01). There were no statistical differences in incidences of coronary heart disease, diabetic retinopathy and diabetic neuropathy between 2 groups (P>0.05). Multivariate Logistic stepwise regression analysis result showed that age, duration of diabetes, hypertension, smoking, levels of glycated hemoglobin and triglyceride were the risk factors for chronic complications in early-onset type 2 diabetic mellitus patients. Conclusions The clinical characteristics are different between early-onset and late-onset type 2 diabetic mellitus patients. Early-onset patients are more prone to diabetic nephropathy, while late-onset patients are prone to macrovascular diseases such as peripheral vascular disease and cerebrovascular disease. Comprehensive management should be administered for early-onset type 2 diabetic mellitus patients to prevent chronic complications especially microvascular complications.

The prevalence of age-related macular degeneration (AMD) is increasing yearly,and AMD has become the first cause of elderly vision irreversible loss.In China,an aging society is developing,so the prevention and therapy for AMD is faced with a new challenge.Thc multi-faceted study on AMD has become a focus of fundus disease in ophthalmology.AMD is thought to be a multifactorial-induced disease,and it is closely related to age,genetic and environmental factors.But its pathogenesis is not understood enough up to now.In recent years,epidemiological study revealed that the chromosome 10q26 has multiple polymorphic loci.Age-related maculopathy susceptibility 2 ( ARMS2,rs10490924 ) is reported to be a major risk factor of AMD in the yellow race.In this paper,the ARMS2 gene epidemiology,cell positioning and related treatment were reviewed.

The paper introduces the current status and the problems of servers in the data center of Institute of Medical Information,Chinese Academy of Medical Sciences,points out the necessity of virtualization in data center,expounds the concept of virtualization and server virtualization technology,then describes the implementation scheme of constructing the server virtualization platform based on VMware vSphere 5.5 products in detail.Finally,the application effect of server virtualization is summarized and the future work is prospected.

Graduation Paper is a key to achieve the objective of cultivating undergraduates majoring in laboratory medicine.To improve the quality of graduation papers,the paper focuses on establishing a system of quality monitoring of graduation papers by students major in laboratory medicine and the difficulties of sustainable developments in graduation papers.

Objective To evaluate efficacy and safety of escitalopram in treating depression. Methods In this randomized, double-blind, double-mimicry, paroxetine parallel controlled study,the study group was treated with escitalopram and the control group with paroxetine. Hamilton Rating Scale for Depression was taken to evaluate efficacy score. Results At the end of six weeks,compared with the total scores of HAMD before and after treatment, escitalopram (17.5±7.8) and paroxetine (16.0±7.9) group both showed the significant difference, while the difference compared between two groups ,the efficacy (87.0% and 81.7%) for depression and side effects were no significance. Conclusion Escitalopram is an efficient and safety antidepressant.

Objective To assess the effect of levothyroxine , lipoic acid and their combination therapy on improving the cognitive deficit and on the level of oxidative stress in the serum and hippocampus tissue of adult hypothyroid rast .Methods Fifty male SD rats were randomly divided into five groups:normal group , hypothyroidism group [ propylthioaracil ( PTU ) group], the levothyroxine sodium (L-T4) treatment group (PTU +L-T4 group), the lipoid acid(LA) treatment group (PTU+LA group), and the two-drug combination group (PTU+LT-4+LA group).After 8 weeks of treatment, the learn-ing and memory abilities of the rats were evaluated by Morris Water Maze ( MWM ) .The content of malondialdehyde ( MDA) and the activities of superoxide dismutase ( SOD) in the serum and hippocampus were respectively measured using thiobarbituric acid ,and xanthine-xanthine oxidase methods .Results Compared with the normal group , the escape latency was longer(P<0.01), the MDA level was increased and the SOD activity was decreased in the serum and hippocampus in the PTU group (P<0.001).Compared with PTU group, the SOD activity was increased and the MDA level was decreased in the PTU +L-T4 group, PTU +LA group and PTU +L-T4 +LA group(P<0.05).There was significant difference in MWM test score .Conclusion The L-T4 and LA combination therapy can significantly improve the cognitive function of hypothyroid rats.

Objective To study the influence of Mutouhui extracts on hemorheology of U14 cervical cancer mice.Methods The U14 cervical cancer mice were divided into Mutouhui extracts high,middle and low dose group,Cisplatin Injection group,model group and blank comparing group.The influence on hemorheology change was observed after being given the medicine.Results The high,middle dose group of Mutouhui extracts and Cisplatin injection group could reduce the blood viscosity of U14 cervical cancer mouse in different shear,and hemotcrit of the low did not obviously change,groups of Mutouhui extracts plasma viscosity changed slightly.Cisplatin Injection group could reduce the blood viscosity,but did not obviously affect to the plasma viscosity.Conclusion Mutouhui extracts can reduce the U14 cervical cancer mouse blood viscosity,and improve the indexes of hemorheology.