Objective:To observe the curative effects of puerarin injection(葛根素注射液) on variant angina pectoris(VAP) and its influences on endothelial functions.Methods:Fortyeight cases with VAP were randomly divided into treated and control group.The treated group was treated with puerarin injection 300500 mg infused intravenously once a day，meanwhile the control group treated with conventional therapy.The therapeutic course was 1014 days for both groups.Before and after using drugs the changes in endothelin(ET) and nitric oxide (NO) were observed in two groups.Results:In both groups after therapy the clinically symptomatic convalescences and changes in electrocardiography (ECG) compared with before therapy had significant differences,but in comparison between two groups the differences had not statistical significant.Otherwise regarding to the ET and NO the differences were significant between treated group and control group.Conclusions:Puerarin injection not only possesses obviously curative effects on symptomatic convalescence and ECG changes but also is able to improve the endothelial functions.

ObjectiveTo investigate the expression of APC-Cdh1 protein after cerebral ischemia-reperfusion injury.Methods60 male Sprague-Dawley rats were randomly divided into Sham-operated group(SH) and ischemia-reperfusion group(IR). The rats of ischemia-reperfusion groups were induced by four-vessel occlusion (4-VO). At different times after injury, the expression of APC-Cdh1 of rat hippocampus was observed by Western blotting and immunohistochemistry.ResultsCompared with sham-operated group, the expression of Cdh1 protein significantly decreased 1 day and increased obviously 3 days, but decreased again 7 days after injury in ischemia-reperfusion group. The immuno-staining showed that APC-Cdh1 was highly cerebral cortex and hippocampus in ischemia-reperfusion group. ConclusionAPC-Cdh1 may be involved in the central nervous system injury.