Objective To investigate closure of different Fisher grade patients with subarachnoid product volume and the degree of cerebral vasospasm aneurysm clipping.Methods Patients with subarachnoid hemorrhage (SAH) were selected from January 2014 to January 2015,including 20 patients with grade Ⅰ,25 patients with grade Ⅱ,and 15 patients with grade Ⅲ.They were divided into 20 patients with aneurysmal SAH(A group),18 patients without aneurysmal SAH (B group) and C group(22 cases).The operation effect was compared.Results C group as the standard,CT preoperative diagnosis had no statistically significant difference among A,B,C group (x2 =0.12,P ＞0.05).After treatment,the cerebral spasticity scores of A,B group were significantly decreased,and the level-Ⅰ and Ⅱ patients decreased more significantly compared with stage Ⅲ patients,the difference between the two groups was statistically significant(x2 =7.05,P ＜ 0.05).In group C,the blood flow velocity at the 7th and 13rd day significantly increased (x2 =7.05,P ＜ 0.05),and velocity of blood flow in group A and B Ⅰ and Ⅱ patients was significantly higher than that of grade Ⅲ patients (t =8.75,P ＜ 0.05).Conclusion For the patients with Fisher grade Ⅰ and Ⅱ,the increase in the volume of subarachnoid hemorrhage,cerebral vasospasm,and the effect of the patients with Ⅲ were more obvious.

Objective To study the value of discriminant analysis of motor unit potential(MUP) multi-parameters in differentiation of various sorts of MUP. MethodsFrom the biceps brachii, tibialis anterior and vastus medialis muscles,the duration, amplitude, area and the ratio of area to amplitude of the MUPs were obtained by use of the spike-wave triggered average technique in 10 patients with myopathic disease, 13 patients with neurogenic disease and 22 healthy adults. The data were subject to analysis of variance and discriminant analysis. ResultsThe differences among the three groups with regard to all the parameters of the MUPs recorded from all the three muscles were statistically significant ( P

China has the largest human biological and pathological tissue resource in terms of both quantity and diversity, whichis true for oral cancer as well. However, this unique and valuable resource did not yield expected results in clinical translational research.On one side, clinicians lack experience in identification of research topics, even with plenty of clinical specimens. On the otherside, researchers consider high impact publications as the top priority instead of clinical significance. The disalignment of the interestsbetween these two sides led to inefficient and inadequate communications and collaborations. To change the current situation, we needto encourage clinicians to raise questions and generate research topics from clinical practice and to actively participate in translationalresearch. Meanwhile, researchers need to understand basics of clinical medicine and design research projects with a focus on clinicalproblems. Closer collaborations between clinicians and researchers will help to identify new biomarkers of clinical significance throughsystematic clinical studies, which have the potential to translate into practical knowledge in diagnosis, treatment and prognosis of diseases.We can further evaluate and validate these translational results systematically by large-scale random clinical trials.

Objective To investigate the changing trends in 4 continuous point prevalence surveys of healthcare-as-sociated infection(HAI)in a hospital. Methods The occurrence of HAI among all hospitalized patients were inves-tigated on a given day from 0:00 to 24:00 in May,2006,2008,2010,and 2012 respectively.Results A total of 4 497 patients should be investigated,4 387 (97.55% )patients were actually investigated;184 patients developed 209 times of HAI,point prevalence rate of HAI was 4.19% ,case prevalence rate was 4.76% . Trendχ2 test showed that HAI prevalence rate decreased gradually from 5.56% in 2006 to 2.76% in 2012(χ2= 14.07,P<0.001).The main infection site was lower respiratory tract (55.03% ),followed by urinary tract(14.83% )and upper respiratory tract(9.57% ).The overall usage rate of antimicrobial agents was 38.50% . Trendχ2 test showed that usage rate of antimicrobial agents decreased gradually from 2006 to 2012(χ2= 5.13,P= 0.023);pathogenic detection rate in pa-tients receiving therapeutic and therapeutic plus prophylactic antimicrobial use increased gradually(χ2= 40.81 ,P<0.001);single use of antimicrobial agents increased gradually(χ2= 23.86,P<0.001). The rate of arteriovenous in-tubation ,urinary catheterization ,respirator use,and venous intubation in patients with HAI was significantly higher than those without HAI (27.17% vs 9.80% ,35.33% vs 11.54% ,13.59% vs 4.33% ,84.78% vs 63.24%respectively ,all P<0.001). Conclusion Management of rational use of antimicrobial agents has been achieved re-markably,control of HAI improved continuously;but control of invasive procedure-associated infection need to be intensified,management of rational use of antimicrobial agents should be paid much attention.

Objective To explore correlations between hepatitis B virus (HBV)genotyping,other clinical information and drug resistance mutations.Methods 358 cases of patients with chronic hepatitis B (CHB)were selected as subjects,and the resistance loci and genotypes were detected by using the polymerase chain reaction(PCR)-reverse dot blot technique.Clinical data,such as ser-um HBV DNA loads,serum levels of alanine aminotransferase(ALT)and hepatitis B virus e antigen(HBeAg),gender,age and length of nucleoside analogues use were collected.Results All samples were successfully amplified positive band.Type B(267 ca-ses)was the main HBV genotype,followed by type C(81 cases)and type D(10 cases).In the 31 1 cases of patients taking nucleoside analogues,269 cases were completely wild type.No drug resistance mutation was found in 47 cases of patients not taking medicine. The drug resistance mutations mainly occured in 204 and 180/204 site.There was no significant correlation between resistance mu-tations and gender,age,serum HBV DNA loads,genotype,serum levels of ALT and HBeAg(P >0.05).While the medication time was longer,the incidence of resistant mutants was greater(P <0.05).The 180 mutation had a certain correlation with 204 site mu-tation(P <0.05).Conclusion PCR-reverse dot blot technology can effectively detect the HBV genotype and mutations,which could effectively guide the clinical medication.

Hepatic venous outflow obstruction is a vascular complication after pediatric liver transplantation.Endovascular treatment has become the first therapeutic option for hepatic venous outflow obstruction after pediatric liver transplantation.The progresses in endovascular treatment of hepatic venous outflow obstruction after pediatric liver transplantation were reviewed in this article.

The eosinophilic otitis media(EOM) is an intractable disease characterized by the presence of a highly viscous yellow effusion with extensive accumulation of eosinophils in the middle ear; granulation tissue can been discovered in the middle ear cavity; most of patients have association with bronchial asthma; resist to conventional treatment for otitis media; EOM patients show gradual deterioration of hearing and sometimes become deaf suddenly; effective treatment involves use of topical and oral steroids. This article summarizes the progress of the EOM's diagnosis and treatment.
Asthma ; complications ; Ear, Middle ; physiopathology ; Eosinophilia ; pathology ; Eosinophils ; Hearing Loss ; complications ; Humans ; Otitis Media ; pathology

[Objective] Probe the source of Nv’ke Baixiao Quanshu or Obstetrics and Gynecology Pandect compiled by Gong Juzhong in Ming Dynasty, explorate the content and academic idea. [Methods]Through investigating and surveying the different editions, col ating and organizing the contents, probe and analyse the writing motivation, content and main idea of the work. [Results] The most contents of Nu ’ke Baixiao Quanshu are inherited from an-other work named Jiaozhu Furen Liangfang with 8 contents:Regulating the menstrual period, praying for children, antenatal training, previous preparation for delivery, parturition, lying-in, difficult labouring. The rest of the contents is extracted from some other works. This work records disease symptoms and medicine, surgery, gynecology and gravidity in various internal organs. Referring ancient classics on disease causes and researching prescriptions and treatments, the author emphasized naturalizing liver, kidney and spleen in warm. Mr. Gong applied drugs corresponding to syndromes. In the Qiusi and Taihou parts, he discussed rationales of infertility, natural endowment and pre-natal and post-natal care and introduced methodology of pulse feeling to diagnose pregnancy, Yuanfang Chao’s twelve col ateral channels in nourishing and training fetus, medicine conditioning for pregnant women, daily regi-men, medicine prohibition, preparation of ante partum. [Conclusion] Nu ’ke Baixiao Quanshu is created by extracting. Mr gong learned widely from oth-er’s strong points and compiled with distinct academic view, significantly guiding development of clinical medicine in department of gynecology of tradi-tional Chinese medical science and formation of system of reproduction care. Yet, some theories like methodologies of gender-oriented reproduction and gender-shifting reproduction should be discarded.

Objective To evaluate the clinical features of nasopharyngeal carcinoma with different sur英文摘要>=rival time and to analyze the factors associated with prognosis improvement.Methods Three hundred and fifty three patients with nasopharyngeal carcinoma treated in our hospital from January 2000 to April 2002 were analyzed retrospectively.They were divided into three groups based on their survival time.One hundred and forty five patients were divided into A groups whose overall survival time were less than five years.Sixteen patients were included in B group whose overall survival time were greater than or equal to five years and less than ten years,and the other one hundred and ninety two patients were divided into C groups whose overall survival time were greater than or equal to ten years.The clinical features were compared and factors associated with survival were identified.Results The 5 and 10 years overall survival rates of the 353 nasopharyngeal carcinoma patients underwent radiotherapy were 58.924％ and 54.391％ respectively.Curative effect of early nasopharyngeal carcinoma was better.Cox regression analysis identified age,N stage,combined with chemotherapy or not and complete remission rate of nasopharynx and neck lymph were independent prognostic factors.Conclusion For nasopharyngeal carcinoma patients,early detection,early treatment,rational comprehensive treatment and complete remission after treatment and complications prevention are important.

The proto-oncogene, c-kit gene, widely expresses on the mast cell, melanoeyte, haemopoietic stem cell, intestinal cell of cajal and germoeyte. Recent researches have revealed the relationship between the e-kit gene and the carcinogenesis, proliferation, infiltration and metastasis of some malignant tumor. This article aimed to make a review of its biological function, lab and clinical research advancement in the digestive tract tumor.