Objective To assessed the relation of hyperuricemia with severity of coronary artery disease(CAD).Methods Three hundred and sixty patients having angiographic evidence of atherosclerosis (CAD + case group,n =360) compared to 150 patients with no luminal stenosis (n =90) and with ＜50％ luminal stenosis (n =60) at coronary angiography (CAD-control group,n =150),all patients be collected between Sep 2009 and Jun 2011 who visited our hospital.Results The mean age of the patients was (60 ± 10) years; the women had a greater prevalence of hypertension,diabetes mellitus,and hyperlipidemia compared to men,with statistical significance[respective as (30.1 ±4.5)kg/m2,165 (56.9％) 104(35.8％),207(71.3％) vs (27.3 ±3.9)kg/m2,118 (53.6％),62(28.2％),139 (63.2),allP ＜0.05),but serum levels of creatinine and uric acid significantly greater for men than women [respective as (119 ± 1.09) μmol/L,(453 ± 10.8) μmol/L vs (106 ±6.3) μ mol/L,(423 ± 12.6) μ mol/L,both P ＜ 0.01].Hyperuricemia was more likely associated with a trend toward higher vessel scores,indicating a more severe CAD (adjusted OR =1.52,P ＜ 0.05) in the whole population.A comparison of sex-specific values showed a significant association existed only in men.Conclusion Asymptomatic hyperuricemia may be associated with the presence and severity of angiographically-defined CAD in patients with suspicious symptoms for CAD.

Objective To compare the clinical effect of two ways of the closed reduction internal fixation and open reduction internal fixation in the treatment of joint injury.Methods According to the digital table,84 patients with joint injury were randomly divided into control group and treatment group,42 cases in each group.The control group was given closed reduction and internal fixation,and the treatment group was given open reduction and internal fixation.Results The total time of operation,postoperative hospitalization time,postoperative joint function recovery time of the treatment group were (78.51 ±10.20)min,(13.35 ±2.46)d,(88.43 ±5.27)d,those of the control group were (118.73 ±25.71)min,(19.72 ±3.57)d,(107.42 ±10.33)d,the differences were statistically signifi-cant(t =9.424,9.522,10.613;P =0.000,0.000,0.000).The excellent and good rate of the treatment group was 90.48%,which was higher than 71.43% of the control group,the difference was statistically significant(χ2 =4.941, P =0.026).The treatment group had 1 case of adverse reaction,the control group had 8 cases of adverse reaction, there was statistically significant difference between the two groups(χ2 =6.098,P =0.014).After treatment,the VAS pain score in the treatment group was (2.11 ±0.68)points,which was lower than (4.98 ±1.35)points in the control group,the difference was statistically significant(t =12.305,P =0.000).Conclusion The application effect of closed reduction and internal fixation for patients with joint injury disease is very obvious.

It is related to the treatment effect of the disease and the quality of life of the patient that perioperative management of ruptured esophagogastric varices bleeding with portal hypertension.According to the individual characteristics of the patient combined with the experience of the surgeons,the key points of individualized treatment consist of accurate and comprehensive preoperative preparation,fine post-operative treatment,and the changes of pre-and post-operative hemodynamics of portal vein system to choose a reasonable procedure,meanwhile,the delicate postoperative managements can improve the surgical effect of portal hypertension.

Oxidative stress is involved in cirrhotic portal hypertension and a close relationship exists between oxidative stress and hyperdynamic circulation.This article elaborates on the function of various reactive oxygen species (e.g.,superoxide anion and hydrogen peroxide) and corresponding anti-oxidants (e.g.,NAD(P) H oxidase inhibitor,the scavengers of superoxide anion,hydrogen peroxide,and vitamin C or E) on the occurrence and development of hyperdynamic circulation in cirrhotic portal hypertension.We observed that the level of reactive oxygen species in cirrhotic portal hypertension was elevated over normal.The potential clinical value is that inhibition or removal of these reactive oxygen species can relieve hyperdynamic circulation and reduce complications for cirrhotic portal hypertension.

The causes of iatrogenic injury in choledo-cho-pancreatico-duodenai junction include iatrogenic factors, anatomic factors and pathological factors. T-tube, methylthionine chloride and fiber choledochoscopy are useful methods for early diagnosis. Accurate exploration of the injury site and reasonable choice of management were significant in dealing with the iatrogenie injury and can lead to a satisfactory result. Choledo-chojejunostomy and Oddi sphincteroplasty are not recommended unless the patients had distal bile duet stricture or the stones can not be removed. Accurate detection of the injury site, evaluation of the severity, and proper choice of the surgical method are important for the prognosis of the patients.

Purpose To study the expression of zeb-1 and c-jun in gastric cancer and its influence of occurrence and development of tumor. Methods The expression zeb-1, c-jun and E-cadherin were assessed in 100 specimens of gastric cancer and their tissue adja-cent to cancer by immunohistochemistry. Results The positive rates of zeb-1,c-jun and E-cadherin expression in gastric cancer were 81%, 70%, 35%, and in tissue adjacent to cancer were 17%, 25%, 100%. The expression of zeb-1 and c-jun in gastric cancer were higher than those in their tissue adjacent to cancer (P<0. 05). zeb-1 expression was closely correlated with the degree of tumor differentiation, depth of invasion, lymph node metastasis and TNM stage (P<0. 05), which were not correlated with patient s age, sex and tumor size. c-jun expression was closely correlated with the degree of tumor differentiation (P<0. 05), which were not correlated with other pathological features. The expression of zeb-1 was negatively correlated with the expression of E-cadherin and was positively correlated with the expression of c-jun in gastric cancer. Patients with high expression of zeb-1 and c-jun had lower five-year survival rate than patients with negative expression. Conclusion zeb-1 and c-jun are closely correlated with occurrence and development of gastric cancer. They can be a index of judging prognosis of gastric cancer.

Objective:To observe the clinical efficacy of acupoint massage plus moxibustion in treating refractory insomnia.
Methods:Sixty patients with refractory insomnia were randomized into two groups, 30 in each group. The treatment group was intervened by acupoint massage on the face and head plus moxibustion at Yongquan (KI 1);the control group was intervened only by the same acupoint massage. For both groups, the treatment was given once a day, and the therapeutic efficacy was evaluated after 4-week treatment.
Results:The total effective rate was 93.3%in the treatment group versus 80.0%in the control group, and the difference was statistically significant (P<0.05).
Conclusion:Acupoint massage plus moxibustion can produce a better efficacy than acupoint massage alone in treating refractory insomnia.

Surgical treatment of cirrhotic portal hypertension and its accompanied abdominal diseases is one of the medical problems currently.Accurate evaluation of the hepatic function reserve,degree of portal hypertension and accompanied abdominal disease is important to decrease the postoperative morbidity and mortality as well as to raise the efficacy.The surgical procedure selection should be based on the analysis of portal vein hemodynamics of patients.There are clear indications for portosystemic shunt,devascularization and combinative surgery with shunt and devascularization.Treatment for portal hypertension should be carried out when treating the accompanied abdominal diseases.The principle of operation,operation time,operation mode,operation sequence,staging indications and the key techniques of operation were discussed in the article.Only these principles be mastered,proper selection of surgical procedures and desired treatment effect with minimal trauma can be achieved.

The hepatic portal system is a unique circulatory system that connects two systems of capillary beds ; one in the wall of the small intestine and spleen and the second in the sinusoidal area of the liver.Therefore,alterations in vasoreactivity (vasodilation and vasoconstriction) play a critical role in the pathophysiology of portal hypertension (PHT).The RhoA/ ROCK pathway exerts an important role in the Ca2+-independent mechanism in vascular smooth muscle (VSM).This mechanism not only modulates the constriction of intrahepatic small vessels and hepatic stellate cells (HSCs) but also effects the hyperdynamic circulation due to vascular hyporesponsiveness.Understanding the detailed mechanism and role of the RhoA/ROCK signal pathway in portal hypertension could be of great utility in providing a new target for portal hypertension therapy.

Objective: To study the relationship between social support,self-consistency and congruence,and subjective well-being of university students.Methods: 360 college students were measured with SSRS,SCCS,SWLS and PANAS.Results: ①Correlation analysis showed that,social support,self-harmony,life satisfaction and positive effects correlated positively with each other(r=0.12~0.28,P