Objective:To observe the intervention effect of acarbose on cerebral arterial thrombosis complicated with impaired glu-cose tolerance(IGT).Methods: Totally 120 cases of IGT patients with ischemic stroke were randomly divided into the observation group (58 cases) and the control group(62 cases). The two groups were given the same basic treatment,while the observation group was treated with acarbose 50 mg,po,tid for 3 months additionally. Before and after the treatment,the levels of blood lipid and blood glucose,serum high-sensitivity C reactive protein(hsCRP) and carotid intima media thickness(IMT) and the other adverse drug reac-tions were detected in the two groups. After 6-month follow-up,the new incidence of IGT was compared between the groups.Results:After the treatment,2 hPG,HbAlc,hsCRP and the other indicators in the observation group were significantly improved when com-pared with those before the treatment(P<0.01 or P<0.05),while only hsCRP in the control group was significantly improved when compared with that before the treatment(P<0.05) and that in the observation group. 2 hPG,HbAlc,hsCRP,IMT and the other in-dicators in the observation group were significantly better than those in the control group(P<0.01 or P<0.05). There was no signifi-cant change in the level of blood lipid in the two groups. There was no adverse drug reaction during the treatment. After the 6-month follow-up,the new incidence of IGT in the observation group was 1.82%,which was significantly lower than that in the control group (7.27%,P<0.05).Conclusion: Among the patients with cerebral arterial thrombosis complicated with impaired glucose tolerance, the normal treatment measures plus acarbose can effectively delay carotid artery IMT incrassation and decrease the risk of cardiovascular events recurrence with better relative safety.

Objective To explore the effects of the health education and nursing pattern based on the transtheoretical model on self-care behavior of patients with non-small cell lung carcinoma (NSCLC) complicated with heart failure. Methods Totally 168 patients with NSCLC complicated with heart failure admitted by the Fourth Hospital of Qinhuangdao were selected and randomly divided into two groups. Patients who received intervention with the health education and nursing pattern based on the transtheoretical model were divided into an observation group, while patients who were treated with the conventional health education and nursing pattern were divided into a control group, with 84 patients in each group. The changes in the self-care behavior and quality of life of the patients in the two groups were observed before and after the intervention. Results There was no statistically significant difference in the indicators of self-care behavior and quality of life between the patients in the two groups before the intervention (P>0.05), while after the intervention, the patients in the observation group showed higher scores in self-care support (59.67±12.89), self-care management (70.21±11.24), self-care confidence (67.98±13.21), physical condition (22.78±5.32), emotional condition (16.45±4.38) and functional condition (16.79±6.22) as well as a higher total score (122.36±16.78) than the patients in the control group (t=7.79,8.26,5.28,4.26,4.28,3.84,5.32;P<0.05). Conclusions The health education and nursing pattern based on the transtheoretical model can effectively improve the self-care behavior and quality of life in patients with NSCLC complicated with heart failure, which is worthy of application.

H 1-antihistamines are widely used in the treatment of various allergic diseases, but there are still many challenges in the safe and rational use of H 1-antihistamines in pediatrics, and there is a lack of guidance on the prescription review of H 1-antihistamines for children.In this paper, suggestions are put forward from the indications, dosage, route of administration, pathophysiological characteristics of children with individual difference and drug interactions, so as to provide reference for clinicians and pharmacists.