ObjectiveTo observe the effect of comprehensive rehabilitation on chronic obstructive pulmonary disease(COPD).Methods10 patients with COPD received COPD training program. Relapse and ability of life were assessed 6 months after intervention.ResultsRe-admission and stay in hospital were 2-5 times and averaged 15 days respectively before intervention while re-admission and stay in hospital were 1-3 times and averaged 9 days respectively after intervention. Ability of life showed self-care, 0 case; partly self-care, 2 cases; no self-care, 8 cases before intervention while self-care, 5 case; partly self-care, 1 case; no self-care, 4 cases.ConclusionComprehensive rehabilitation can improve the quality of life of patients with COPD.

Breast-conserving surgery (BCS) has become the most common treatment for breast ductal carcinoma in situ (DCIS).BCS followed by radiotherapy (RT) can reduce the risk of recurrence.However,controversy exists regarding the region of RT,which low-risk patients can avoid RT after BCS,and the role of accelerated partial breast irradiation (APBI) in the treatment of BCS.However,most trials have indicated that all DCIS patients can obtain benefit from RT after BCS.Further prospective studies are warranted to identify whether RT can be safely omitted for low-risk patients with DCIS.Long-term results of ongoing studies on outcome of BCS alone suggest that RT should be routinely recommended after BCS for all patients except those with contraindication.

Objective To explore whether childhood abuse experiences predict higher levels of depression and lower levels of self-esteem for graduate students and examine the mediating role of social support between childhood abuse and mental health.Methods A sample of 907 graduate students were investigated with the Childhood Trauma Questionnaire (CTQ-SF),Perceived Social Support Scale (PSSS),Self-esteem Scale (SES) and Center for Epidemiological Survey Scale (CESD).Results The scores of childhood abuse,social support,self-esteem,and depression of graduate students were (33.88±9.35),(68.31±12.01),(36.62±4.80) and (35.85± 9.20).Childhood abuse was negatively correlated with self-esteem (r=-0.32,P＜0.01),but positively correlated with depression (r=0.28,P＜0.01),and negatively correlated with social support (r=-0.44,P＜0.01).Social support was positively correlated with self-esteem (r=0.39,P＜0.01),and negatively correlated with depression (r=-0.41,P ＜0.01).Examining the mediation model indicated that social support had a partial mediation effects(42％) on the relationship between childhood abuse and self-esteem,and social support had a partial mediation effects(54％) on the relationship between childhood abuse and depression.Conclusions The childhood abuse not only affects the graduate student's self-esteem and depression directly,but also can take the same effect by social support indirectly.

Objective ToexpresschimericantigenofHCVwithmultipleimmunodominantepitopes inE .coliforimprovingthequalityofreagentsforHCVscreening .Methods Thegenefragmentencoding HCVchimericantigenwasobtainedbymolecularcloningmethodandclonedintopQE 30 plasmidforex pressioninE .coliM 15 .TheexpressedchimericantigenwaspurifiedbyNi NTAandcoatedonELISA platestoanalyzeitssensitivityandspecificity .Results Thechimericantigenof 5 30 0 0washighlyex pressed .ELISAassayofserumsamples (including 18HCVpositiveand 17negativesera)indicatedthatthe HCVchimericantigenhadhighsensitivityandspecificity .Conclusions ChimericantigenofHCVwith typicalimmunodominantepitopescanbeusedtodevelopgoodreagentsforHCVimmunoassay .

Objective To study the change of pancreatic hemocirculation in patients with acute pancreatitis by magnetic resonance perfusion (MRP) and to explore its relationship with pancreatic severity. Methods With a prospective investigation method, APACHEⅡscores, systemic inflammatory response syndrome (SIRS) scores, Binder scores and C-reactive protein (CRP) values were recorded within 72 h in patients with severe acute pancreatitis (SAP,n=15) and mild acute pancreatitis (MAP,n=17), while other 19 volunteers were as controls. MRP were performed on 32 patients and 19 controls. Patients in SAP group were evaluated by above criteria after two-weeks treatment and MRP were performed in 12 of them. All cases with bolus injection of Gd-DTPA (0.2 mol/kg) were scanned by transversal same slice and fast spoil phase gradient echo. Three groups datum of MIR and MSR were gained by ROI time-signal graphy of pancreatic head, body and trail which were calculated by Perfxproject software. Results ① The rates of MIR and MSR in SAP group were lower than MAP group (P0.05).Conclusion MRP is an objective imaging technique, which can reflect the hemocirculatory variety in acute pancrea-titis.It may have a considerable value in evaluating the severity of acute pancratitis.

Objective: To investigate the mediating effect of parent-child conflict on paternal phubbing and externalizing behavior problems in children, so as to provide insights into the prevention and interventions of childhood externalizing behavior problems. Methods: The fathers of children at ages of 3 to 6 years were sampled from seven kindergartens in Liaoning Province and one kindergartens in Sichuan Province using a convenience sampling method in June 2021. The Generic Scale of Phubbing, the Parent-child Relationship Scale, and the Strengths and Difficulties Questionnaire in Children were employed. The mediating effect of parent-child conflict on paternal phubbing and externalizing behavior problems in children was examined using a structural-equation model and Bootstrap method. Results: A total of 583 questionnaires were allocated, and 531 valid questionnaires were recovered, with an effective recovery rate of 91.08%. The fathers had a mean age of (34.86±8.39) years, and 172 fathers had an educational level of bachelor degree and above (32.39%) and 285 had a single child (53.67%). Among paternal phubbing questions, the mean scores of nomophobia, interpersonal conflict, self-isolation and problem acknowledgement dimensions were (3.71±1.53), (2.02±1.18), (2.26±1.29) and (3.07±1.38), respectively, and the mean score of parent-child conflict was (2.25±0.82). Among all childhood externalizing behavior questions, the mean scores of conduct and attention deficits/hyperactivity dimensions were (0.31±0.26) and (0.82±0.46), respectively. Paternal phubbing posed an direct positive effect on childhood externalizing behavior problems (β=0.165, P=0.005), and indirectly affected childhood externalizing behavior problems (β=0.449, P<0.001) via parent-child conflict (β=0.358, P<0.001). The mediating effect of father-child conflict was 0.161 (95%CI: 0.104-0.221), and was contributed 49.39% to the total effect. Conclusions Parent-child conflict plays a partial mediating role in the association between paternal phubbing and childhood externalizing behavior problems. Paternal phubbing may directly affect childhood externalizing behavior problems, and may indirectly affect childhood externalizing behavior problems through the positive effect on parent-child conflict.

Objective: To explore the mediating effects of adolescent loneliness and depressive symptoms on interparental conflict and adolescent non-suicidal self-injury, so as to provide insights into the prevention and interventions of adolescent non-suicidal self-injury. Methods: Students from 7 middle schools in Tianjin, Henan, Sichuan, Zhejiang and Inner Mongolia were selected using convenient sampling method. Their loneliness, depressive symptoms and non-suicidal self-injury occurrence were investigated using the Three-Item Loneliness Scale, the Center for Epidemiological Studies Depression Scale and Non-Suicidal Self-injury Scale, and interparental conflict was evaluated by adolescents and their mothers respectively, using the adolescence revision of Co-parenting Scale and the Co-parenting Relationship Scale. The mediating effects of loneliness and depressive symptoms on interparental conflict and non-suicidal self-injury was examined using a structural-equation model. Results: A total of 544 students were recruited, with a mean age of (14.19±; 1.43) years. There were 241 males (44.30%) and 303 females (55.70%); 452 junior high school students (83.10%), 46 high school students (8.45%) and 46 vocational high school students (8.45%); and 150 students with non-suicidal self-injury (27.57%). The scores of loneliness, depressive symptoms, parental conflict evaluated by students and their mothers were (4.38±; 1.87), (7.32±; 6.06), (14.10±; 8.03) and (3.04±; 3.19), respectively. The results of structural equation model analysis showed that parental conflict had no direct effect on non-suicidal self-injury, but loneliness (β=0.074, 95%CI: 0.038-0.114) and depressive symptoms (β=0.096, 95%CI: 0.061-0.136) played indirect effects on interparental conflict and non-suicidal self-injury, and they also exerted a chain mediating effect (β=0.064, 95%CI: 0.037-0.095) (all P<; 0.05). Conclusion Interparental conflict can impact adolescent non-suicidal self-injury through the mediating effects of adolescent loneliness and depressive symptoms.

OBJECTIVE:To evaluate clinical efficacy through comparing the change of CT image in infrapatellar fat pad before and after Xiaoding ointment in the treatment of acute patellar bursitis of knee joint. METHODS:73 patients with acute patellar bur-sitis were randomly divided into observation group(39 cases)and control group(34 cases). Observation group was given Xiaoding ointment for local application,qd,7 d as a courses,3 courses in total;control group was given triamcinolone acetonide 30 mg af-ter the extraction of articular cavity effusion,once a week,totally for 3 times. All patients of two groups underwent knee CT exami-nation for observation of the infrapatellar fat pad and articular cavity effusion volume change before and after treatment. Clinical ef-ficacies were compared between 2 groups. RESULTS:CT image alterations of treatment group showed that infrapatellar fat pad den-sity were decreased,anteroposterior diameter,vertical diameter,internal to external diameter were significantly reduced. The total effective rate of treatment group was 92.31%,which was better than that of control group(88.24%),with statistical significance (P<0.05). CONCLUSIONS:Xiaoding ointment demonstrate markedly curative effects in the treatment of acute patellar bursitis, and CT image is an effective method for diagnosis of infrapatellar fat pad.

Objective: To examine whether there are differences between dependent and independent individual’s shame and sad memories. Methods: Self -report measures were used. Results: ① There were significant interactions between emotion and cognitive style of the number of words recalled, number of times that others were mentioned. ②Field dependent individuals mention more emotional behaviors and presence of others. ③The subjects mentioned more emotion words and time in sad memories. ④In shame memories, there were less self-references than others-references, marginally less self in thinking than self in other descriptions. ⑤In sad memories, field dependent individuals reported less selfreferences than others-references, and less self in thinking than self in other descriptions. ⑥There were more emotional behaviors and self-thinking in sad memories than in shame memories. Conclusion: Field dependent and independent individuals demonstrate differences in emotional memory, and the difference is emotion specificity.

Objective:To investigate the relationship between base level of Cyfra21-1,SCCA,TK1 and lung cancer prognosis.Methods: A nested case-control study was conducted.721 lung cancer cases who had no distant metastasis were recruited baseline population from January 2010 to January 2013.About 2 years follow-up,364 cases of death or brain (or multiple) metastasis were identified as case group, and the other 357 cases were included in the control group.The level of serum Cyfra21-1,SCCA,TK1 was detected.The relationship between base level of Cyfra21-1,SCCA,TK1 and lung cancer prognosis were analyzed.Results: The age in the case group was (59.3±10.1),and the control group was (59.0±9.9).There were obvious differences in body mass index,smoking index,pathological type,clinical stage,lymph node metastasis and with chronic diseases between case group and control group(P<0.05),while no difference in pleural effusion,comprehensive treatment etc(P>0.05).There were differences in the base level of Cyfra21-1,SCCA,TK1;and there were differences in Cyfra21-1,SCCA,TK1 distribution between case group and control group(P<0.05).There was difference in the base level of Cyfra21-1(P<0.05),while no differences in SCCA,TK1(P>0.05) in patients with different stages of lung cancer.There were differences in the base levels of Cyfra21-1 and SCCA(P<0.05),while no differences in TK1(P>0.05) in patients with different pathological types of lung cancer.Logistic regression analysis results showed that the OR value of SCCA,TK1 with lung cancer prognosis were respective 7.235(1.674-14.613),5.009(0.973-10.778),5.816(0.879-16.235).Conclusion: The baseline level of Cyfra21-1 can reflect the prognosis of lung cancer patients,while SCCA,TK1 not.