Objective To explore the effects of adefovir velocimeter(ADV) combined with Thymopeptides α1 in treatment of patients with chronic hepatitis B (CHB) against hepatitis B virus (HBV). Methods 67 cases of CHB of positive HBeAg were divided into coupling group and single group. 34 cases of coupling group, after being treated for 26 weeks with thymopeptides α1 and ADV,continued to be treated 52 weeks with ADV. 33 cases of single group were treated for 52 weeks with ADV alone. Alanine aminotransferase periodically (ALT), total bilirubin, HBV DNA,HBeAg,anti-HBe were detected at regular intervals. Efficacy were evaluated after finishing the treatment. Results The liver function were both improved obviously in two groups (P ＞ 0. 05). Frequencen of seroconversio of HBeAg/anti-HBe and negative conversion ratio of HBV DNA were much higher in coupling group than that in single group(P ＜ 0. 05). Conclusions The effects were better with Thymopeptides α1 and ADV than that with single ADV. Coupling Thymopeptides α1 and ADV could help to resist and remove HBV.

Objective To explore the clinical significance of blood serum AFP determination in gravis type viral hepatitis. Methods The level of blood serum AFP was determined by radioimmunoassay in 85 eases of gravis type viral hepatitis, and its change was observed in a dynamic state. Results The abnormality rate of AFP was 83. 6% in the patients of gravis type viral hepatitis. The abnormality rate of AFP in acute gravis type viral hepatitis was significantly lower than that in suhacute severe hepatitis and chronic severe hepatitis(P < 0.01). The survival rate in the team with high level of AFP was significantly higher than that of teams with normal or low level of AFP(P <0.01～0.05) in the patients of gravis type viral hepatitis. The blood serum AFP level in the survivors was significant-ly higher than that of the death in the patients of gravis type viral hepatitis(P <0.01). Conclusions The blood ser-um AFP determination in gravis type viral hepatitis,can be used as a sensitive index for prognosis. A high level of AFP indicates that the hepatic cells regeneration is active and the prognosis is relatively better.

Objective To study the relationship between serum fibrosis parameters levels and chronic viral hepatitis B patients.Methods Radioimmunoassay and chemiluminescence were used to test the levels of hyaluronic acid(HA),collagen type Ⅳ(Ⅳ-C),laminin(LN) and procollagen type Ⅲ(PC Ⅲ) in 146 cases of chronic hepatitis B and 40 of normal controls,and the relationship with clinical parameters of liver function were analyzed.Results The levels of HA,Ⅳ-C,LN,PC Ⅲ in chronic hepatitis B patients were higher than those of normal control group (P ＜0.05 or P ＜ 0.01),there were statistical differen in different course of disease (P ＜ 0.05 or P ＜ 0.01) ; The levels of serum Ⅳ-C and PCⅢ had positive correlation with plasma PT,the same to HA with TBil and PCⅢ with ALT;The levels of HA,Ⅳ-C and LN had negative correlation with Alb,the same to LN with CHE.Conclusion The levels of HA,Ⅳ-C,LN and PC Ⅲ in chronic hepatitis B patients may reflect the situations of hepatic fibrosis and the degrees of liver function damage.

Objective To investigate the effects of N-acetylcysteine (NAC) on the expression of cardiac adiponectin and its receptors in streptozotocin-induced diabetic rats. Methods Thirty-two male Wistar rats were randomly divided into four groups, with 8 in each: untreated control group (C group), NAC-treatment group (CT group), diabetic untreated group (D group) and diabetic NAC-treatment group (DT group). After 8 weeks, plasma glucose and insulin, and cardiomyocyte cross sectional area were measured. Cardiac protein expression of adiponectin receptor 1 and 2 (adipoR1 and adipoR2), AMP-activated protein kinase ? (AMPK?), phosphorylation of AMP-activated protein kinase ?-subunits and glucose transporter 4 (GluT4) were determined by Western blotting. Plasma and myocardial adiponectin levels were measured by radioimmunoassay. Plasma and myocardial free 15-F2t-isoprostane levels were assayed by enzyme immunoassay. Results Compared with C group, the ratio of ventricular weight to body weight and cardiomyocyte cross-sectional area, plasma and levels of free 15-F2t-isoprostane in myocardium and the protein expression of myocardial adipoR1 increased significantly in diabetic rats (D group) (P

Pain due to chronic soft tissue injury of the neck and shoulder is a commonly encountered and frequently occurring condition. Traditional Chinese medicine is a common course of treatment for soft tissue injury and may have better therapeutic effects than biomedical options.

ObjectiveTo evaluate multi-slice CT (MSCT) in glenoid bone loss of patients with recurrent anterior shoulder dislocation.Methods MSCT findings of 108 patients with recurrent anterior shoulder dislocation and 12 with single anterior shoulder dislocation were retrospectively studied.The incidence,degrees and locations of glenoid bone losses were recorded.The incidence was analyzed with Fisher exact test.The maximum length,depth and proportion were compared with Wilcoxon rank sum test.ResultsGlenoid bone loss was detected in 91.7％ (99/108)patients with recurrent anterior shoulder dislocation.The proportion of glenoid bone loss was ( 16.0 ± 6.0)％,and the central locations of glenoid bone loss were from 2: 20 to 4: 25 ( mean 3: 20).Sixty-two percent (67/108) patients had bony Bankart lesions in which 58.2％ (39/67) bony fragments were free and 41.8％ (28/67) were adherent to the anterior border of the glenoid cavity.Seventy-five percent (9/12) patients with single shoulder dislocation had anterior glenoid bone loss,and the proportion of glenoid bone loss was ( 15.2 ± 7.1 ) ％.There were no statistical differences of the incidence (P =0.100) and proportion of glenoid bone loss ( P =0.453 ) between the recurrent and single anterior shoulder dislocation.ConclusionsAnterior glenoid bone loss is common in patients with recurrent anterior shoulder dislocation.

tralateral parietal lobe. Conclusions CIMT can improve the patients' upper-limb function effectively. The constraint-induced movement of the affected arm during CIMT appears to induce cortical reorganization and compensation as measured by fMRL

Objective To determine the specific recognition of Echinococcus granulosus (E.g.) cyst fluid crude antigen (EgCF) and antigen B (EgB) by serum specific IgG and IgE using Western blotting during anaphylactic shock induced by E. g. in sheep, and to investigate the importance of defined characteristics and molecular weight of the specific antigens. Methods EgCF was obtained through local slaughterhouses in Urumqi from the cysts of infected sheep liver. Western blotting was used to analyze total specific IgG and IgE antibodies in serum from sheep infected with E.g. using either crude antigen of E. g. and EgB, and to understand specific recognition of hydatid cyst antigens by serum total IgG and specific IgE. Results SDS-PAGE and Western blotting showed that there were differences between EgB and EgCF in electrophoresis pattern. EgB was recognized by IgG from sera of infected sheep in a series of bands with molecular weight ranging from 31, 43 to 66.2 kDa. No binding of IgG against EgCF was observed in any serum from the infected sheep during anaphylactic shock. In contrast, specific IgE antibodies in E. g. infected sheep obviously recognized the single 43 kDa subunit of EgCF, but no binding of specific IgE against EgB was observed in sera of the infected sheep. Conclusion EgCF is consisted of antigenic components in which there is a specific antigen against IgE with a molecular weight of over 43 kDa. This component may lead to an anaphylactic shock induced by E. g. . EgB is a specific antigen against the total IgG but not to the specific IgE.

Objective To investigate the change of specific antibodies IgG, IgG1 subclass and IgE in sheep infected with Echinococcus granulosus(E.g) during anaphylactic shock, and to observe antigen B reactivity against IgG antibody in E.g\|infected sheep. \ Methods\ Antigen B and crude antigen were prepared with E.g cyst fluid (EgCF) from infected sheep. The enzyme\|linked immunosorbent assay(ELISA) was used for detecting the level of specific IgG, IgG1 and IgE during anaphylactic shock in sheep induced by E.g. \ Results \ The level of specific IgG, IgG1 and IgE was significantly higher in the infected sheep after 6 months than that of the uninfected control group (P

Objective To investigate the effect of atorvastatin intensive therapy on cardiac function and lipoprotein phospho‐lipase A2 (Lp‐PLA2) in patients with hypertension complicated with ST segment elevation acute myocardial infarction .Methods Totally 78 patients with hypertension complicated with ST segment elevation acute myocardial infarction from June 2014 to April 2016 in our hospital patients ,according to the random number table method divided into observation group (atorvastatin therapy ) and control group (routine treatment) .The changes of blood pressure ,blood lipid ,Lp‐PLA2 ,cardiac function of two groups were compared before and after treatment .Results Before treatment ,there was no significant difference in blood pressure and blood lipid between the two groups (P>0 .05) .After treatment ,the two groups of patients with SBP ,DBP ,LDL‐C significantly decreased , HDL‐C significantly increased ,and compared with the control group ,the SBP ,HDL‐C ,LDL‐C in the observation group were signif‐icantly different (P<0 .05) .Before treatment ,there was no significant difference in Lp‐PLA2 between the two groups(P>0 .05) . After treatment ,the two groups of patients with Lp‐PLA2 were significantly reduced ,and the observation group was significantly greater (P<0 .05) .Before treatment ,there was no significant difference in cardiac function between the two groups (P>0 .05) .Af‐ter treatment ,the observation group of patients with LVESD ,LVEDD significantly decreased ,LVEF ,CO ,CI significantly in‐creased ,compared with the control group ,the difference was statistically significant (P<0 .05) .Conclusion Atorvastatin intensive therapy can significantly reduce high blood pressure acute ST segment elevated blood pressure and Lp‐PLA2 levels in patients with acute myocardial infarction and improve cardiac function ,worthy of promotion .