Objective To investigate the protective effect of ischemic pre-conditioning(IPC) on the spinal cord injury associated with abdominal aortic cross-clamping. Methods Forty-eight New Zealand white rabbits were randomly divided into IPC group and ischemic group. The concentrations of endothelin-1(ET-1), prostacyclin(PGI_2) and thromboxane A_2(TXA_2) in spinal cord were measured at six different time intervals, before ischemic, 40 minutes after ischemic, 2 hours,8 hours,24 hours and 72 hours after reperfusion. Neurologic function and pathological changes were documented. Results In IPC group, ET-1 level, TXB_2 level and TXB_2/6-keto-PGF_ 1? ratio were significantly reduced, while 6-keto-PGF1? level was significantly increased compared with that of ischemic group (P

Objective To investigate the difference of serum prealbumin in hospitalized children and its value in Screening Tool for the Assessment of Malnutrition in Pediatrics ( STAMP) in hospital-izedchildren.Methods 867hospitalizedchildrenwererecruitedfromMarch2013toApril2014in the First Affiliated Hospital of Fujian Medical University .All the patients were assessed using STAMP and collected venous blood sample for measuring serum prealbumin within 24 hours after admission.All the patients were surveyed for information regarding gender , age, dietary changes, etc.and their clini-cal data and laboratory results during hospitalization collected .The patients were divided into high mal-nutrition risk group ( HMRG) and low malnutrition risk group ( LMRG) according to STAMP scores upon admission. Results There were 463 children ( 53.4%) in HMRG, and 404 in LMRG (46.6%).Compared with the LMRG, the HMRG had significantly lower serum prealbumin [ (144.7 ± 50.6) mg/L vs.(173.6 ±71.3) mg/L, t=6.795, P=0.000].After controlling for age, course of disease, white blood cell count, albumin, glutamic-oxalacetic transaminase, C-reactive protein in covariance analysis, the HMRG still had significantly lower serum prealbumin than the LMRG [ estimate ( 95% CI): 139.8 ( 134.9 -144.8 ) mg/L vs.157.9 ( 151.9 -163.8 ) mg/L, F =20.433 , P=0.000 ) .Clinical cure rates in HMRG with low serum prealbumin , HMRG with normal serum pre-albumin, LMRG with low serum prealbumin, and LMRG with normal serum prealbumin were 62.9%(95/151), 80.5% (251/312), 77.1% (27/35), and 98.1% (362/369) (χ2 =112.80, P=0.000 ) , respectively; incidences of hospital acquired infection were 21.9% ( 33/151 ) , 8.7%( 27/312 ) , 22.9% ( 8/35 ) , and 1.9% ( 7/369 ) (χ2 =63.55 , P =0.000 ) , respectively. Conclusion High malnutrtion could be distinguished more accurately using the combination of the as-sessment of malnutrition screening tools and serum prealbumin measurement .

Objective:To evaluate therapeutic effect of olmesartan on patients with mild to moderate essential hyper-tension (EH) and its influence on cardiovascular risk factors .Methods:A total of 150 mild/moderate EH patients were enrolled using opened ,non-control and multi-center method .According to random number table ,they were randomly and equally divided into olmesartan group (received olmesartan 20~40 mg/d) and losartan group (re-ceived losartan 50~100 mg/d) .Changes of systolic blood pressure (SBP) ,diastolic blood pressure (DBP) , levels of risk indexes of cardiovascular diseases ,such as high sensitive C reactive protein (hsCRP) ,urinary albumin/creati-nine ,homocysteine (Hcy) and carotid intima-media thickness (IMT) were observed in two groups before and after treatment .Results:After eight-month treatment , compared with before treatment , all indexes significantly im-proved in both groups;compared with losartan group ,there were significant reductions in SBP [ (145 ± 12) mmHg vs .(132 ± 9) mmHg] and DBP [ (90 ± 7) mmHg vs .(80 ± 5) mmHg] , P<0.01 all;and significant reductions in levels of hsCRP [ (0.54 ± 0.09) mg/L vs .(0.34 ± 0.09) mg/L] ,urinary albumin/creatinine [ (26.5 ± 19.4) mg/g vs .(23.1 ± 18.3) mg/g] ,Hcy [ (13.2 ± 4.8)μmol/L vs .(10.3 ± 4.2)μmol/L] and IMT [ (0.83 ± 0.29) mm vs . (0.74 ± 0.28) mm] in olmesartan group , P< 0.05 all .Conclusion:Besides intensively lowering blood pressure olmesartan can also significantly decrease cardiovascular risk factors in patients with mild to moderate hypertension .

Objective To investigate the influence factors of malnutrition risk in hospitalized children,in order to provide theoretical basis for early identifying hospitalized children at the risk of malnutrition and for guiding clinical nutritional intervention.Methods Hospitalized children in the Department of Pediatrics of our hospital from March 1st 2013 to April 30th 2014 were included and assessed using Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP).Questionnaire survey was conducted and clinical data was recorded.The children were divided into two groups according to STAMP scores upon admission,namely high malnutrition risk group and low malnutrition risk group.Comparing the differences of basic characteristics,laboratory examinations,and treatments between the two groups,associated factors of statistical significance were detected.With the associated factors identified in single factor analysis as independent variables and STAMP score-based group division as the dependent variable,multifactor unconditional Logistic regression analysis was performed to explore the independent risk factors influencing STAMP scores of hospitalized children.Results A total of 1 406 hospitalized children were included,of whom 738 were at high malnutrition risk,and the other 668 were at low malnutrition risk.Single factor analysis indicated that fever before admission (Z =-3.809,P =0.000),severity of condition (x2 =14.068,P =0.000),age (x2 =5.813,P =0.017),and length of fever before admission (t =2.793,P =0.005) were associated with high malnutrition risk of hospitalized children.Non-conditional Logistic regression suggested that severity of condition (OR =1.557,95％ CI:1.164-2.083,P =0.003),length of fever before admission (OR =1.039,95％ CI:1.011-1.068,P =0.006),and granulocyte count (OR =1.032,95％ CI:1.004-1.061,P =0.027) were risk factors of high malnutrition risk in hospitalized children,and age (OR =0.942,95％ CI:0.909-0.977,P =0.001) was protective factor.Conclusion Age,severity of condition,length of fever before admission,and granulocyte count can provide helpful information for early identification of hospitalized children at high malnutrition risk.

Objective To compare the sensitivity and specificity of neutrophil CD64 and C-reactive protein( CRP) in the diagnosis of bacterial infection by Meta-analysis. Methods A computerized literature search of PubMed,Embase and Science Citation Index Expanded was conducted to retrieve studies related to evaluating the diagnosis value both of neutrophil CD64 and CRP in bacterial infectious diseases before January 2015. The methodological quality of each included study was assessed. The method of statistical analysis was dichotomous Meta- analysis using STATA 12. 0 software. Results Ultimately we included a total of 10 studies with 1 057 specimens in neutrophil CD64 group and 1 063 specimens in CRP group. Neutrophil CD64 compared with CRP in the sensitivity,OR=1. 755,95%CI(1. 041,2. 958),P=0. 035,while in the specifici-ty,OR=0. 620,95% CI(0. 442,0. 870),P=0. 006. Conclusion In the diagnosis of bacterial infectious dis-eases,neutrophil CD64 is better than CRP in the sensitivity,but,CRP is better than neutrophil CD64 in the specificity.

Objective: To discover and determine the content of kaempferol in Sedum aizoon L.for the first time.Methods: Waters HPLC-MS/MS,XTerra-MS C18 (5?m,2.1?150mm) and the mobile phase consisted of acetonitrile-water-formic(40∶60∶1) were applied to find kaempferol in Sedum aizoon L.;Daojin HPLC and the SHIM-PACK VP C18(250nm?4.6nm,10?m) column were used.The mobile phase consisted of methanol-0.4% phosphoric acid solutions(59:41) with the flow rate at 1.0ml/min and the UV detector wave-length were set at 370nm.Results: Compared with standard sample,the thing that kaempferol exists in Sedum aizoon L.was confirmed.The calibration curve was in good linearity over the range of 2.0-8.0?g,and regression equation was Y=40343X-11107(r=0.9998).The average recovery rate was 102.53%,with RSD =0.92%(n=6).Conclusion: The method is simple,accurate and reproducible so it can be used to determine and analyze the content of kaempferol in Sedum aizoon L.

Objective To observe the influence of atorvastatin on serum high sensitive C-reactive protein (hs-CRP) levels and arteriosclerosis plaque of coronary artery in patients with unstable angina. Methods Thirty subjects with arteriosclerosis plaque of coronary artery were given atorvastatin 20 mg qd for 12 months.The serum levels of hs-CRP were detected before and 12 months after treatment in all patients with helical computerized tomography. Results After 12 months administration of atorvastatin, The serum levels of hs-CRP reduced( P

Objective To investigate the correlation of father involvement with early social adaptation behaviors.Methods With social adaptation scale for infant-junior middle school' s student and a self-made questionnaire,1246 normal children,age from 16 to 72 months,were investigated.Regression analysis was performed to get the correlation of social adaptation with time and activities of father involved.Results After controlling for mother-,child- and family-related factors,the regression analysis showed that standard score of social adaptation was positively rehted with the time of father involved ( β =0.05,P=0.03 ),the time father invloved explain 12％of the variation of social adaptation.The father-child activities were related with social adaptation behavior,playing was related with work skills (β =0.09,P＜0.01 ) and socialization ( β =0.06,P＜0.05),story listening related with communication ( β =0.07,P ＜ 0.05) and self-management ( β =0.06,P ＜ 0.05 ),other activities related with self-dependence ( β =0.07,P＜0.05) and work skills ( β =0.06,P＜0.05).Conclusion The time and activities of father involved are related with children' s social adaptation.The effect of father involvement on early social adaptation is positive.

Objective To study the chemical constituents from mangrove Excoecaria agallocha.Methods The chemical constituents were separated and purified by chromatographic methods after solventextraction and were identified by spectroscopic analyses(EI-MS,1D NMR).Results Twelve compoundswere isolated from this plant and identified as:14-taraxeren-3-one(Ⅰ),dibutyl phthalate(Ⅱ),?-amyrin(Ⅲ),18-oleanen-3-ol(Ⅳ),18-oleanen-3-one(Ⅴ),phaeophytin A(Ⅵ),betulin(Ⅶ),?-rosasterol(Ⅷ),?-sitosterol(Ⅸ),betulinic aicd(Ⅹ),oleanolic acid(Ⅺ),ursolic acid(Ⅻ).Conclusion CompoundsⅦ,Ⅷ,Ⅹ,andⅫare isolated from this plant for the first time.

ObjectiveTo investigate the correlation of lipids and lipoproteins with cardiac function in patients with coronary heart disease (CHD).MethodsParameters of blood pressure, serum lipids and lipoproteins, clinical features, radionuclide ventriculographic and coronary angiographic findings were analyzed retrospectively in 584 CHD patients treated with standard treatment.ResultsThe left cardiac dysfunction of CHD patients was correlative positively with age, systolic blood pressure (SBP), diastolic blood pressure (DBP), blood glucose, body mass index (BMI), smoking, total cholesterol(TC) and low density lipoprotein cholesterol(LDL-ch) significantly(P<0.001), not correlative with high density lipoprotein-cholesterol (HDL-ch). The left ventricular ejection fraction (LVEF) and left ventricular peak filling rate (LVPFR) were decreased along with the levels of TC and LDL-ch increased (P<0.05～0.01).ConclusionTC and LDL-ch are positively correlative with left cardiac dysfunction in CHD patients. In order to reduce cardiac damage of CHD associated with hyperlipoidemia, more attention should be paid to the amelioration of coronary arteriosclerosis and the reduction of serum lipids and lipoproteins.