1.200 cerebral hemispheres were used to observe the morphology of the brain sulci. 2.The superior and inferior frontal sulci not only run from tbe precentral sulcus or in the front of it,but also run behind it. 3.The posterior end of the collateral sulcus may extend to the superolateral sur- face of the occipital lobe. 4.The orbital sulci are irregular but generally are of the ?-shaped and H- shaped. 5.Anterio-superiorly to the cingulate sulcus a parallel accessory cingulate sulcus is usually present. 6.The intraparietal and intraoccipital sulci are usually continuous. 7.The superior and inferior transverse occipital sulci are present at the same time,being over 80% of the total number. 8.The parieto-occipital sulcus which commences on the superolateral surface is over 90% of the total number. 9.The calcarine sulcus is divided into four types,among which the“superior convex”and “linear”types are present more often. 10.Most of the superior sagittal cunuate sulcus and the inferior sagittal cunuate sulcus are present. 11.The lingual sulcus is constant.Its configuration is changed,following the change of the posterior part of the calcarine fissure and the posterior end of the collateral sulcus.

Objective To observe the effects of Jianpi Xiaopi extract on gastric secretion of experimental SD rats with spleen deficiency. Methods Animal model of spleen deficiency was established by using Rhubarb decoction. The gastric secretion was determined by titration method, and the gastrin in plasma was measured by radioimmunoassay. Results Compared with those in spleen deficiency group, the levels of the total acidity and the output of total acid were higher in the middle dose group treated with Jianpi Xiaopi extract ( P

Objective To investigate the anti-inflammatory effect of artemisinin (ART) encapsulated by β-lactoglobulin (BLG) nanoparticles on Winnie spontaneous ulcerative colitis mouse model. Methods BLG-ART nanoparticles were prepared and their effects on the solubility and stability of ART were evaluated. A mouse model of colitis induced by dextran sulfate sodium (DSS) was used to compare the therapeutic effects of artemisinin (ART) administered by direct gavage and artemisinin encapsulated by β-lactoglobulin nanoparticles (BLG-ART) administered by gavage. Winnie mice were randomly divided into blank group, ART group and BLG-ART group. Mice in the ART group were given 50 mg/kg ART by gavage; mice in the BLG-ART group were given the same dose of BLG-ART nanoparticle PBS dispersion by gavage; mice in the blank group were given the same amount of PBS by gavage, for 16 days. The body mass and disease activity index (DAI) of each group of mice were measured. HE staining was used to observe the pathological changes of mouse intestinal tissue, and real-time quantitative PCR was used to detect the mRNA expression levels of TNF-α, interleukin 1β (IL-1β), IL-10 and IL-17 in mouse colon tissue. Results Compared with the ART group and the blank group, the body mass of the BLG-ART group increased and the DAI decreased after 16-day treatment; the crypt structure of the proximal and distal colon regions of the mice recovered; goblet cell loss decreased; neutrophil infiltration decreased and the mRNA expression levels of pro-inflammatory and anti-inflammatory cytokines were significantly down-regulated. Conclusion ART-BLG can alleviate intestinal inflammation in spontaneous ulcerative colitis mice.
Animals ; Mice ; Colitis, Ulcerative/drug therapy* ; Nanospheres ; Inflammation ; Administration, Oral ; Artemisinins ; Disease Models, Animal ; RNA, Messenger