Objective To investigate the Relationship between blood pressure variability rate and extent of critically in ill patients with sepsis. Methods From May 2012 to April 2013 in our hospital, 60 cases of sepsis patients for the study were divided into APACHE-II≥20 points(critical group)and APACHE-II<20 minutes(non-critical group), selected the same period to our hospital for medical examination of 30 cases of healthy subjects (control group). The risk and non-risk reorganization reorganization patients 24 h SBP-CV,24 h DBP-CV,dSBP-CV,dDBP-CV,nSBP-CV, nDBP-CV mutation rate, mutation rate and blood pressure APACHE-II score correlation analysis. Comparison of the three groups of patients with high-density protein cholesterol (HDL-C), low-density protein cholesterol (LDL-C), inter-leukin-6(IL-6),interleukin-18(IL-18)were compared. Results The danger of recombinant APACHE-II score was(29.56±0.79), non dangerous recombinant APACHE-II score was (13.15±0.58). Two groups of SBP mutation rate comparison, with statistically significant difference(P<0.05). Spearman analysis showed that 24 h SBP-CV,dSBP-CV,nSBP-CV,related to the mutation rate and APACHE-IIscore was positively(r=0.762,P=0.003). Critical group,non criti-cal group,control group HDL-C, LDL-C gradually increased, IL-6, IL-18 were lower, with statistically significant difference between the two groups (P<0.05). Conclusion The rate and blood pressure variability in the degree of sep-sis in critically ill patients was positively correlated, the mechanism may be the promotion of IL-6, inflammatory kookiness such as IL-18 secretion,and expand the inflammatory response.

Objective To explore the clinical value of tests of plasma type B natriuretic peptide (BNP) and troponin I (TnI) for elderly patients with sepsis. Methods A total of 108 elderly patients with sepsis who were admitted and treated in our department from January 2011 to January 2014 were selected. They were assigned to three groups according to the disease severity, 64 patients with common sepsis were as group A, 32 patients with severe sepsis were as group B, and 12 patients with septic shock were as group C. After being admitted to our department, mass concentration of plas-ma BNP and TnI for all patients were tested immediately. LVEF value of patients was tested by ultrasonic cardiogram, and APACHE II score was calculated. 28-day survival conditions for patients in group B and group C were followed up, each index between surviving patients and dead patients and connections between scores of BNP, TnI and APACHEIIwere compared. Results TnI and BNP for patients in group A were (0.08±0.01)μg/L and (206.42±76.15) pg/mL re spectively, in group B were (0.53±0.01) μg/L and (386.38±84.96) pg/mL respectively, in group C were (1.94±0.04) μg/L and (958.84±135.23) pg/mL respectively. The differences of mass concentrations of plasma BNP and TnI among the three groups were statistically significant (P<0.05). The more severe the disease conditions, the higher the mass con-centrations of plasma BNP and TnI. TnI and BNP for patients in the survival group were (0.47±0.08) μg/L and (692.59±22.17) pg/mL respectively, APACHEII was scored as (19.5±5.2), and LVEF was (52.1±13.9)%, while in the dead group were (1.23±0.05) μg/L, (986.25±22.65) pg/mL, (23.1±6.1) Scores, (41.5±11.5)%. The scores of BNP, TnI and APACHEII in dead group were significantly higher than those in the surviving group, and LVEF in dead patients was significantly lower than that in the survival group, the differences were statistically significant (P<0.05). Conclusion Mass concentration of plasma BNP and TnI can be used as effective indices for disease evaluation and prognosis for el-derly patients with sepsis.