Objective To investigate the effect of narrow-band UVB combined with tacrolimus ointment in the treatment of vitiligo,and its influence on IL-17 and IL-22 in peripheral blood.Methods 100 patients with vitiligo were selected as study subjects,and they were divided into the control group and observation group according to the random number table method,50 cases in each group.The control group was given 0.1% tacrolimus ointment,the observation group was treated with narrow-band UVB combined with 0.1% tacrolimus ointment.After 6 months of treatment,the clinical treatment effect of the two groups was observed.The levels of serum IL-17 and IL-22 were detected by ELISA,the differences between before and after treatment were compared between the two groups.Results The cure rate,effective rate of the observation group were 74.0%,96.0%,respectively,which were significantly higher than 62.0%,84.0% of the control group,the differences were statistically significant(x2=3.125,2.897,all P<0.05).The levels of IL-17 and IL-22 in the two groups before treatment had no statistically significant differences(all P>0.05).After treatment,the levels of IL-17 and IL-22 in the two groups significantly decreased(t=3.454,3.032,all P<0.05),which in the observation group were lower thanthose in the control group(t=3.867,2.665,all P<0.05).Conclusion Narrow-spectrum UVB combined with tacrolimus ointment has good clinical effect on vitiligo,which can effectively improve the local immune response.

Objective:To solve the problem which the time of various information systems were not synchronization and there were time error in them through adopted synchronization time server of dual-mode satellite that were global position system (GPS) and Beidou navigation satellite system (GPS/BDS).Methods: By introducing the synchronization time server of dual-mode satellite (GPS/BDS), the time could be synchronization in real-time with satellite time of GPS/BDS through antenna. And then, using it to ensure the time of server could accurately realize synchronization with international coordination time. All of servers or workstations that need achieve time synchronization chose the IP address of internet time synchronization server as special IP address of time server in the interior framework of hospital so as to achieve synchronization in operation on appropriate frequency. Through the terminal program of time server to append the IP address of digital clock so as to realize the time of digital clock getting synchronization with time server.Results: The synchronization time server of dual-mode satellite (GPS/BDS) could ensure the accuracy of time in operating system of various servers and workstations, and ensure the accuracy of acquisition time of various application system. Therefore, it ensured the accuracy of recording time in data base of various information system of hospital, and resolved the problem which the time of various information systems were not synchronization and there were time error.Conclusion: The server of local area network(LAN), workstation and digital clock can achieve synchronization with universal time coordinated(UTC) by using synchronization time server of dual-mode satellite (GPS/BDS), and it can obtain good effect.

Objective To investigate the effect of compound glycyrrhizin combined with fexofenadine hydrochloride in the treatment of chronic urticaria and its effect on plasma histamine.Methods 100 patients with chronic urticaria were selected as study objects,and they were divided into the control group(50 cases) and observation group(50 cases) according to the random number table method.The control group was treated with fexofenadine hydrochloride,while the observation group was treated with compound glycyrrhizin on the basis of the control group.The clinical effect and plasma histamine level were compared between the two groups.Results The effective rate of the observation group was 96.0%,which was significantly higher than 84.0% of the control group(χ2=7.951,P<0.05).After treatment,the plasma histamine content of the observation group was (2.38±0.26)ng/mL,which was lower than (3.10±0.29)ng/mL of the control group,and the difference between the two groups was statistically significant(t=6.084,P<0.05).Conclusion The compound glycyrrhizin combined with fexofenadine hydrochloride in the treatment of chronic urticaria can reduce the symptoms of the patients,reduce the number and size of the patients and effectively control the clinical symptoms of the patients.And it can effectively reduce the level of plasma histamine in patients with good clinical effect and application value,it is worth to be promoted in clinical.

Objective To study the relationship between peripheral blood regulatory T cells CD4 + and the antiviral effect in the patients with chronic hepatitis C.Methods 128 patients with chronic hepatitis C after antiviral treatment and follow-up were col-lected as the experimental group,the peripheral blood was respectively extracted before treatment and after treatment and at 24-week follow-up.The flow cytometry was adopted to detect CD4 + percentage.Moreover the liver function indexes and HCV-RNA quantitation were detected.80 individuals were selected as the normal control group.Results HCV-RNA quantitation,AST,ALT, CD4 + (%)had statistical differences between the the experimental group and the control group(P <0.05);the HCV-RNA quantita-tion,AST,ALT,CD4 + (%)levels after treatment and 24-week follow-up in the experiment group were significantly decreased(P <0.05).Conclusion The antiviral treatment can effectively reduce the damage of chronic hepatitis C,raise the cure rate,reduce the liver damage.The peripheral blood CD4 + regulatory T cells can be used as the index of the antiviral treatment efficacy and hepatitis C virus(HCV)infection.

Since the success of the first case of laparoscopic cholecystectomy in 1987,minimally invasive surgery has become the most active field in all the branches of surgery.The traditional concept of surgery needs to be changed as the rapid development of surgical procedures,medical materials and devices,and the requirement of biopsychosocial model of medicine also poses great challenges to today's surgeons.Traditionally trained surgeons may find it difficult to adapt to the new developments.While,on the other hand,young laparoscopists may be at a loss when facing the difficulties encountered during the laparoscopic operation.The surgeons of tomorrow should have profound base of the knowledge of surgery and skillful in laparoscopy at the same time.

Traumatic biliary stricture,usually iatrogenic during biliary surgeries,is still a disastrous mistake because of its serious consequences.As the rapid development of hepatic surgery and liver transplantation and widespread use of laparoscopic cholecystectomy,patterns of traumatic biliary stricture changes in result as more complicated.In the future,more will be expected from the changes of the view point that the biliary system is actually an organ rather than merely an excretory duct,and,further more,the preservation of integrity of physiological function of the biliary tract should be considered during surgical repair.A simplified classification of bile duct injuries and biliary stricture is presented for discussion.

Ankle joint fracture is only taken anterior-posterior and lateral radiography normally. But when the lateral ankle fracture, the fracture line can not be clear displayed . When ankle inclined 15 degrees is postured, fracture lines can be visualized clear with anterior-posterior and lateral posture.

The philosophic mode of bi-cyclic and tri-cyclic mutual crosses have the connotations of the dynamic development and change,reciprocity and transformation,and the unity of opposites.It possesses the peculiarities of the brachylogy and straight view as a method for thinking and studying on the problems of the medicine and other scientific system.It can play an important role in training the students' innovative thinking,their ability to discover and solve problems.

Maintaining social equity and helping vulnerable groups is an important function of government,and helping poor college students is an important aspect of maintaining education equity.On the basis of investigation and research,we analyze the major problems and weak-points in the police of poor college student aid and propose some suggestions on completing the aid-policy and aid-systems for poor college students.

AIM　To study the efffects and mechanisms of hetrazane（diethylcarbmazine citrate，DEC）on contraction of isolated tracheal strips of guinea pigs. METHODS　Using isolated tracheal strips technique. Each tracheal strip was placed in an organ bath filled with a Krebs solution of 37℃ and various drugs was added respectively. It was determined that KCl or 5-HT induced the contractile effects and its dose-response curve on tracheal strips and DEC or verapamil changed the effects of KCl or 5-HT. RESULTS　The contractions induced by KCl or 5-HT in isolated tracheal strips of guinea pig were markedly inhibited by DEC, the IC50 value of DEC for contraction induced by KCl and 5-HT was 5.03 mmol*L-1 and 9.54 mmol*L-1 respectively. DEC caused rightward displacement of the dose-response curse for KCl and 5-HT, and significantly depressed the maxmal response, showing anon-competitive antigonism, the pD′2 values were 1.554 and 1.851 respectively, and DEC markedly inhibited the contractions induced by Ca2+ released from an intracellular store and extracellular Ca2+. CONCLUSION　DEC can significantly inhibit contraction of tracheal strips induced by KCl and 5-HT, and its mechanism is responsible calcium-antagonistic effect of DEC.