Objective :To prove ischemia-modified albumin (IMA ) is an early index to adjust acute hemorrhagic myocardial ischemia with animal experiment .Methods :Twenty-four SD rats (group A) were bleeding with Hb dropped to 100 ,90 ,80 ,70 , 60 g/L .When serum IMA ascended obviously ,killed the rats and judged myocardial damage .Twenty-four SD rats (group B) were bleeding with Hb dropped to 100 ,90 ,80 ,70 ,60 g/L .When serum cTnT ,CK-MB ascended obviously ,killed the rats and judged myocardial damage .Twenty-four SD rats (control group) were bleeding with Hb dropped to 100 ,90 ,80 ,70 ,60 g/L ,and they were infused with albumin at the same time .When cTnT ,CK-MB of blood ascended obviously ,killed the rats and judged myocardial damage .Results :IMA of blood in SD rats of group A increased to (64 .2 ± 3 .1) U /mL when Hb was 80 g/L (P< 0 .05) .cTnT ,CK-MB ,NT-proBNP of blood had no changes at this time ,and no myocardial damage have been found .NT-proBNP of group B increased to (1175 .3 ± 274 .1) pg/mL when Hb was 60 g/L (P< 0 .05) ,cTnT of group B increased to (1 .48 ± 0 .33) ng /mL when Hb was 60 g/L (P< 0 .05) ,CK-MB of blood increased to (91 .8 ± 7 .0) U /L when Hb was 60 g/L (P< 0 .05) ,and rats had myocardial damage at this time point .IMA of blood in SD rats of intervention control group had no changes at each time point .NT-proBNP of blood climbed to (879 .8 ± 83 .5) pg/mL when Hb was 60 g/L (P<0 .05) .cTnT of blood climbed to (1 .03 ± 0 .02) ng/mL when Hb was 60 g/L (P< 0 .05) .CK-MB of blood climbed to (86 .2 ± 7 .0) U /L when Hb was 60 g/L (P< 0 .05) ,and rats had myocardial damage .Conclusions :The animal experiment had proved that ischemia-modified albumin is an early index to adjust acute hemorrhagic myocardial ischemia .