BACKGROUND: Quality of life, which is induced as a completely evaluating system to reflect new healthy viewpoints and medical patterns, plays a key role in supplying traditional therapy and evaluating rehabilitation efficacy in occupational injury.OBJECTIVE : To analyze the effects of occupational injury on quality of life in mining area of Tongling, Anhui.DESIGN: Case contrast questionnaire, Logistic single factor analysis and multiple factors analysis.SETTING: Workers General Hospital of Tongling Nonferrous Metal Group; Mining Safety Office of Tongling Nonferrous Metal Company.PARTICIPANTS: A total of 234 subjects with occupational injury were selected from four subgroups of Tongling Nonferrous Metal Company from January 2000 to December 2005 and regarded as the occupational injury group.Injured grade was evaluated by the department of safety in production. In addition, 206 employees of the same sex were regarded as the control group. All subjects provided the confirmed consent.METHODS: Questionnaires were finished in December 2006. Besides those whose educational level was lower than primary school or illness state was severe, their questionnaires were filled by somebody else through asking the feelings,and other subjects filled in the questionnaires by themselves. ① Social demography characteristics were surveyed in the two populations. ② The World Health Organization Quality of Life Assessment-100 (WHOQOL-100), which was characterized by excellent reliability, validity and sensitivity, was used to survey influencing factors (sex, age, occupation,educational level, marriage, smoking, drinking, pay, type of work in production, grade of occupational injury, injured site and type, other diseases, average income of per family member, housing area of per family member, accidental types,character styles, sleeping status, etc.) and various dimensions reflecting quality of life [physiological function (body ache,vigor, sleeping), mental state (well-being feels, confidence, and other three aspects), independence (daily living ability,work ability, and other two aspects), social relationship (interpersonal relation, social communication, and other one spect), material life (reliability, housing environment, and other eight aspects) and faith (individual faith)]. There were 24 aspects and every aspect included four items; in addition, there were 4 items in general healthy status. Therefore, there were 100 items in total. LinearitY method was used to score each item (from 1 tc 5 points). Self-scored quality of life had only one item, which was scored based on hundred-mark system. ③ Quality of life of subjects in the occupational injury group was analyzed with one-way analysis of variance. Variously dimensional indexes of quality of life in 6 fields were regarded as dependent variance, and effect factors were regarded as independent variance. The data were analyzed with multiple stepwise regression analysis.MAIN OUTCOME MEASURES: ① Characteristics of social demography; ② scores of variously dimensional indexes of quality of life; ③ correlation between quality of life and effect factors in occupational injury group.RESULTS: All 234 patients in the occupational injury group and 206 subjects in the control group were involved in the final analysis. ① There were no significant differences in sex, age, occupation, educational degree, working duty,marriage, drinking, smoking, pay, having other diseases and occupational types between the two groups (P ＞ 0.05). ②Scores of physiological field, independence field and total quality of life were lower in the occupational injury group than those in the control group (P ＜ 0.05). ③ Effect factors on quality of life in the occupational injury group contained intoxication and asphyxia; ankle, foot and cranial injuries; avulsed wound and task degrees. Multiple factor analysis demonstrated that quality of life of patients in the occupational injury group was affected by waist injury, pay level and relationship with colleagues and family member.CONCLUSION: Quality of life is inferior in the occupational injury group to that in the control group. The effect factors are mainly focus on injured sites, accident and injured types, economic status and relationship with society and family member.

Objective To explore the protective effect mechanism of minocyline on the model of the cerebral ischemia-reperfusion of gerbils by decreasing expression of phosphorylation P38MAPK.Methods A cerebral ischemia-reperfusion model in gerbils was established by clamping both common carotids.The ultrastructural alteration in pyramidal neuron in the hippocampal CA1 and the cortex of frontal lobe at different time was observed by electron microscope.And observe the expression level of phosphorylation P38MAPK by using immunohistochemistry technique.Results ①The damage to the neunos became more and more severe as gerbils survived longer postocclusion.Minocyline treated groups were lessened obviously.② Treatment with minocycline reduced expression of phosphorylation P38MAPK with a significant difference(P

0 05); At the 7th day, T?RⅠ mRNAs expression was decreased( P

The objective of this paper is to build a real-time and highly efficient platform for medical information in wartime.The different characteristics of the wartime medical information are analyzed.Based on the hospital information system,and centering on rescue timeliness,continuity,and quality as well as the coordination of medical service command,a wartime medical information platform is designed,which is significant to the medical work in wartime.

Objective To investigate the expressions and its relationship of vascular interleukin-6(IL-6) and signal transducer and activator of transcription 3(STAT3) protein in giant cell arteritis patients.Methods The expressions of IL-6 and STAT3 protein were detected by immunohistochemistry in the temporal artery biopsy specimens of 20 patients with giant cell arteritis and 6 patients with other nerve system diseases(control group).Six indexs related to inflammation in giant cell arteritis patients were recorded.Giant cell arteritis patients were divided into the group that ≥3 positive indexs(7 cases) and the group that ≤2 positive indexs(13 cases).The relationship between expressions of IL-6 and STAT3 protein was analysed.Results Compared with control group[(2.00?0.63)score,(30.73?10.84)cell/H],the expressions of IL-6 and STAT3 protein in temporal artery were significantly increased in giant cell arteritis group[(2.85?0.75)score,(40.71?9.90)cell/H](all P

Objective To study the curative effect and clinical safety of gimeracil and oteracil potassium combined with oxaliplatin in treatment of advanced gastric carcinoma patients.Methods From January 2009 to December 2011,116 cases with advanced gastric carcinoma were randomly chosen and divided into group A,B (58 cases in each group).Group A was given gimeracil and oteracil potassium combined with oxaliplatin,while group B was given oxaliplatin,fluorouracil and calcium folinate.Before and after dosing,the blood routine,liver and kidney function,chest CT scanning and gastroscope inspection were observed,the recent curative effect and adverse reaction of chemotherapy were analyzed.The patients' survival time and disease progression were compared.Results The curative effect of 116 patients could all be evaluated,and the effective rate of group A and group B were 48.3％(28/58) and 29.3％(17/58),while clinical benefit rate were 74.1％(43/58) and 55.2％(32/58),there was significant difference(P ＜ 0.05).The survival rate of two groups at different time points had no significant difference (P ＞0.05).The rate of nauseated and vomiting were 34.5％(20/58),37.9％(22/58) in group A,and 67.2％(39/58),62.1％(36/58) in group B,there was significant difference (P ＜ 0.05).The influence of drugs on blood system,common peripheral neurotoxicity,extremities syndrome and inflammation of the oral mucosa between two groups had no significant difference (P ＞0.05).Conclusions Gimeracil and oteracil potassium combined with oxaliplatin in treatment of advanced gastric carcinoma patients has better clinical effect and less complication,which is worthy of further promotion.

Objective To study the effects of transient cerebral ischemic reperfusion(IR) and flunarizine on the expression of plasminogen activator inhibitor-1(PAI-1) protein in brain tissue of gerbils.Methods A cerebral transient ischemic-reperfusion model in gerbils was established by clamping both common carotid.The gerbils were fed with flunarizine before experiment in flunarizine treatment group.The expression of PAI-1 protein in brain tissue was detected by immunohistochemistry technique at the 1,3 and 7 days after IR.Results There was slight expression of PAI-1 protein in the brain tissue of gerbils in the normal control group and sham operation group.Compared with normal control group,the expression of PAI-1 protein in neurons and gliacytes of ischemic gerbils was evidently increased at the 1,3 and 7 days in the cerebral ischemia group(all P

0 05); T?RI mRNA expression was increased at the 1st, 3rd and 7th day, while T?RⅡ mRNA expression was increased at 1st and 3rd , and decreased at the 7th day, compared with normal and sham operation group (P

Objective To investigate the ultrastructural features and it's significance of the skip area with giant cell arteritis(GCA).Methods 20 GCA patients and 7 non-GCA patients underwent temporal artery biopsies. The sections were stained with HE and methylene blue(MB) for light microscopy(LM), doubly stained with uranyl acetate and lead curate for electron microscopy (EM). 20 GCA patients were divided into skip area GCA group(14 cases) and active inflammatory cell infiltration GCA group(6 cases) according to the definition of skip area or skip lesion. The ultrastructural changes of each group were observed by EM and assessed by using 4 grades from 0 to 3 scores.Results The scores of ultrastructural changes were as follows: the skip area GCA group, 0 in 1 patient, 2 to 6 in 9 patients, and 8 to 9 in 4 patients; the active inflammatory cell infiltration GCA group, 7 to 15 in 6 patients; the non-GCA group, 0 to 1 in 6 patients, and 5 in 1 patient. The scores of the three groups were tested by H check, the difference was evidently significant( P0.05) in comparison with active inflammatory cell infiltration GCA group.Conclusions At electron microscopic level, the skip area of temporal artery biopsy with GCA showed obvious pathological changes, especially in the intima of artery. The results suggest that the investigation of ultrastructure features of the skip areas of temporal artery with GCA may be benefit for the diagnosis and treatment of this disease.

Objective On the basis of previous experiments ,we try further to seek the new evidences of α7nAChR participating in 100 Hz electroacupuncture (EA ) regulating natural killer (NK ) cells activity .Methods α7nAChR antibody and the specificα7nAChR antagonist α-bungarotoxin (α-Bgt) were used to study the effect of α7nAChR on NK cell activity in 100 Hz EA mice .Re-sults Compared with 100 Hz EA group ,100 Hz EA plus α7nAChR-Ab group showed a significant enhanced in NK cell activity (P<0 .05) .100 Hz EA treated with 1 .5 or 3 .0 μg α-Bgt groups had higher NK cell activity than 100 Hz EA group(P<0 .01) . Conclusion α7nAChR is involved in 100 Hz EA modulation for immune function ,which provide the theoretical and practical basis for further clarifying and expanding the clinical application of EA .