1.The diagnosis of acute appendicitis with MSCT
Journal of Chongqing Medical University 2007;0(10):-
Objective:To analyse the diagnostic of multislice CT(MSCT)for acute appendicitis.Methods:Sixty-seven patients with acute appendicitis confirmed by surgery and histopathology were analyzed retrospectively.The sizes of appendixes,appendolith,periappendiceal changes were observed and noted.Results:Sixty-four of the sixty-seven patients were correctly diagnosed as acute appendicitis.The direct CT signs of acute appendicitis were an enlarged appendix(82.08%).Indirect signs includedappeniceal perityphlitis(73.13%) and preiappendicular abscess(11.94%);and three cases were not observed with CT.Conclusion:Acute appendicitis has a variety of CT signs which is helpful to improve the diagnosis.
2.Metabolic syndrome an obesity-related cardiometabolic syndrome
Chinese Journal of Endocrinology and Metabolism 1986;0(04):-
Metabolic syndrome(MS),as a clinical issue,has been proposed for over half a century. However,no consensus on its definition,pathogenesis and treatment has been reached so far.What is the entity of MS?Whether it is one kind of disease or constellation of several risk factors has been argued.Recent studies have shown that abdominal obesity is the most important feature of MS,which is linked with adipose tissue dysfunction and insulin resistance.Atherosclerotic cardiovascular disease is the main clinical outcome of MS.Thus, intervention of abdominal obesity is a key target for controlling MS and its complications.Although MS is composed of multiple subtypes,it is helpful for us to understand its entity and guide the clinical practice if we regard MS as an obesity-related cardiometabolic syndrome.
3.Management strategy of diabetic macrovascular disease: From intensive glycemic control to harmonious equipoise
Chinese Journal of Endocrinology and Metabolism 2009;25(4):361-365
asize the strategy of simultaneously modifying all of the risk factors, harmonious equipoise of intervention and tailoring treatment.
4.Prospect and challenge for metabolic surgery in treatment of type 2 diabetes mellitus
Chinese Journal of Diabetes 2015;(9):769-772
[Summary] Clinical studies have confirmed that metabolic surgery is an effective method for the treatment of diabetes ,which can significantly relieve symptoms of type 2 diabetes ,improve various complications and reduce cardiovascular events. Currently ,major limitations of this technique in clinical practice in China include the lack of understanding on surgical benefits ,difficulty in selection of surgery indications and division‐based treatment modalities. Thus ,we should explore a cooperation model of multi‐discipline teams ,understand the mechanisms of type 2 diabetes remission by metabolic surgery and develop physician internist leading standard post‐operation management. These strategies will greatly promote the development of metabolic surgery for type 2 diabetes in China.
5.Obesity-related cardiovascular risk and its appropriate intervention
Chinese Journal of Endocrinology and Metabolism 2011;27(9):707-710
Obesity is a major risk factor for the prevalence of cardiovascular diseases ( CV D) in China. The application of imaging techniques is helpful to diagnose the visceral fat obesity. A Large number of studies show a positive relationship between the cardiovascular morbidity and obesity. However, there is not a linear correlation between the prognosis of CVD and the degree of obesity, for example, too high or too low body mass index (BMI) or body fat ratio may increase the risk of CVD mortality. The function and type of adipose tissue determine the impact on cardiovascular system, thus, maintaining an appropriate BMI and body fat ratio is beneficial. Besides weight gain control and prevention of cardiovascular events, one goal of antiobesity is to improve the sickness of adipose tissue.
6.The Clinical Effect of Valsartan on Blood Pessure of Patients withEssential Hypertension
Chinese Journal of Tissue Engineering Research 2001;5(11):156-
Objective To compare the effects of Valsartan on blood ressure(BP)of patients with mild to moderate essential hypertension(EH).Method 64 patients with EH were randomly divided into 2 groups:Valsartan group(Enalapril 10 mg bid n=32).Treatment lasted for 8 weeks.Result Valsartan and Enalapril significantly reduce BP compared with that bdfore treatment(P< 0.05),effective rate and magnitude of decreasing BP were no significantly different between two groups(effective rate of Valsartan group was 78.1% vs 70.0% in Enalapril group(P>0.05).Conclusion Valsartan and enalapril have effect for decreasing the BP in EH patients.
7.Progress of researches on nano-scaffold material used in spine tissue engineering
Orthopedic Journal of China 2006;0(14):-
With the rapid development and wide application of nano-techonology,the development of spine tissue engineering materials has been ushered into a brand field.Because of its unique effects of promoting cell adhesion,proliferation and function,nano-meterial will play more and more important role in the research on spine cord injury repair.
8.Research progress on JAK/STAT signaling pathway and the inhibitor AG490 in lymphoma
Chinese Journal of Clinical Oncology 2014;(19):1221-1224
JAK/STAT includes many types of cell factors. Growth factor signal transduction is an important pathway and widely participates in cell multiplication, differentiation, and immunity adjustment. Aberrant-activated JAK/STAT signaling pathway is in-volved in carcinogenesis. Recent studies demonstrated that abnormal expression and activation of STAT3 were found in lymphoma. Constitutive activation of STAT3 promotes development, invasion, and metastasis of cancer. AG490, a JAK2 inhibitor, can block the JAK/STAT3 signal pathway and reduce the pathway's downstream STAT3 expression. Several studies showed that AG490 can inhibit cell proliferation and promote apoptosis in lymphoma. AG490 combined with chemotherapy drugs could improve sensitivity. In our study, we reviewed the potential role of JAK/STAT signaling pathway and the blocker AG490 in lymphoma.
9.Research progress of injected hydrogel in the treatment of myocardial infarction
International Journal of Biomedical Engineering 2013;(1):56-60
Due to myocardial necrosis and fibrous scar formation after acute myocardial infarction,patient's ventricular remodeling and cardiac function is reduced,which will cause serious impact on the long-term prognosis of patients with myocardial infarction.As new biological substitute materials,the hydrogels are superior in hydrophilicity and biocompatibility and have been widely used in the research of myocardial infarction's treatment.The hydrogels can be used alone or served as a promising cell/drug delivery vehicle.Many reports show that intramyocardial injection of hydrogels attached with stem cells and drugs can prevent left ventricle (LV) wall thinning,increase arteriole and capillary density,raise restoration ratio of implanted stem cells,facilitate controlled release of bioactive drugs,limit post-ischemic remodeling and preserve LV function in a certain extent.This article reviews injectable hydrogels research progress in the treatment of myocardial infarction.
10.Roles of NF-?B activation and TNF-? expression in heart failure following myocardial infarction in rats
Ping XIE ; Shanjun ZHU ; Zhiming ZHU ;
Journal of Third Military Medical University 2003;0(19):-
Objective To investigate the effects of nuclear factor ?B (NF ?B) activation and tumor necrosis factor ?(TNF ?) expression on the progressive heart failure following myocardial infarction in rats. Methods Male rats were randomized for the proximal left anterior descending branch coronary artery ligation and then killed at 4, 8 and 12 weeks after ligation for the examination of hemodynamic parameters, ventricular mass index, protein expression of TNF ?, and NF ?B activity. Sham operated rats were used as the control group. Results Compared with the sham operated group, the myocardial infarction rats showed significant decreases in mean arterial pressure(MAP), maximal ascending and descending velocity of the left ventricular pressure(?dp/dt max ) and a significant increase in left ventricular end diastolic pressure(LVEDP) ( P