Objective To compare clinical effects between cilostazol(CLT)alone and cilostazol combined with pancreatic kininogenase(PK)on lower extremity arterial disease in diabetic patient(LEADDP).Methods Patients with LEADDP were randomly divided into 2 groups:single medication group or the control group(53 cases)and combination group or the treatment group(53 cases).Sugar-reducing medicines were given before and after treatment to keep a steady blood glucose level.The control group took CLT orally 100 mg each time,twice a day.Besides receiving the same dose of CLT,the treatment group took 120 tablet of PK on an empty stomach,three times a day,with the duration of 3 months.Clinical symptoms,ankle/brachial index(ABI),blood rheology,nailfold microcirculation,intimal medial thickness(IMT)and plaque thickness were compared between the 2 groups after treatment.Results Symptoms in both groups improved after treatment.ABI was elevated significantly compared to that before treatment(P<0.05)and the change was more obvious in combination group.The difference of ABI after treatment between the 2 groups had statistical significance(P<0.05).IMT of the right foot dorsal artery,and left and right posterior tibial artery increased significantly compared to that before treatment(P<0.05).Plaque thickness decreased compared to that before treatment(P<0.01)and the difference between before and after treatment in combination group was significantly greater than that in single medication group(P<0.05).Conclusion Cilostazol combined with pancreatic kininogenase has better clinical effects than cilostazol alone in treatment of patients with LEADDP.

In recent years, the study of orthodontics was achieved more attentions in stomatology. The extraction or non-extraction orthodontic treatment were summarized. Extraction of premolars orthodontic treatment can improve the third molar inclination. This might be useful in clinical application.

Objective To study the efficacy and the influence on immunological function of combination with shenfu and intra-artery chemotherapy for invasive bladder cancer. Methods Group A(36 cases)were treated with shenfu injection and chemotherapy protocol of intra-artery chemotherapy, and group B (30 cases)were treated only with intra-artery chemotherapy. Results The effective rate of group A was higher than group B.And the changes of immunological function,side effects,gastrointestinal response in group A were obviously lower than those in group B(P＜0.05).Conclusions Patients with shenfu injection and intra-artery chemotherapy significant lower influence than those with only intra-artery chemotherapy.The curative effect of shenfu injection and intra-artery chemotherapy is significant.

asize the strategy of simultaneously modifying all of the risk factors, harmonious equipoise of intervention and tailoring treatment.

Objective To observe the clinical effect of intra-articular injection of sodium hyaluronate combined with rehabilitation training in treatment of knee osteoarthritis, and their effects on β endorphin and substance P levels in plasma. Methods All 106 cases with knee osteoarthritis were divided into treatment group and control group. Treatment group were treated by intra-articular injection of sodium hyaluronate combined with rehabilitation training, and control group underwent rehabilitation training only. Knee joint function was evaluated using Lysholm scores before and six weeks after treatment, and at 3-month and 6-month follow-up. Meanwhile, the concentrations of β endorphin and substance P in plasma were tested in the two groups. Results Compared with pre- treatment, the Lysholm scores were obviously increased after 6-week treatment, at 3-month and 6-month follow-up in both groups, with more obvious increase in treatment versus control group (P＜0.01). The Lysholm scores were higher in treatment group than in control group (P＜0.01). The concentration of β endorphin in plasma was significantly increased, and the substance P concentration in plasma was decreased after treatment in both groups. There were also significant differences in concentrations of β endorphin and substance P in plasma between treatment group and control group (P＜0.01). Conclusions Intra-articular injection of sodium hyaluronate combined with rehabilitation training is effective in improving knee joint function in elderly patients, in relieving pain and in enhancing joint movement.

Objective To explore the clinical efficacy of adefovir dipivoxil in treatment of liver cirrhosis.Methods 45 cases with liver cirrhosis admitted in 302 Military Hospital of Chian in 2012 were randomly divided into experiment group(n=25)and control group(n=20).Experiment group was treated with adefovir dipivoxil,and control group was given traditional therapy.Two groups were treated for six months.Renal function,liver function and liver firosis were examined with every month,the recovery indexes of renal function between two groups were detected and compared after treatment, which was used to judge the clinical efficacy of adefovir dipivoxil. Results Before treatment,there were no significant differences in the thickness of spleen,serum indexes of portal vein,splenic vein and hepatic fibrosis between experiment group and control group.After treatment,the liver and spleen condition and liver fibrosis index including HA,LN,PCIII,IV-C in two groups were significantly improved by B ultrasound and serum detection,and the improvement degree of experimental group was significantly higher than control group(P<0.05).Conclusion Adefovir dipivoxil has better therapic efficacy in treatment of liver cirrhosis.

Objective To explore the clinical characteristics and rehabilitation training of abnormal lateral consonant, namely/l/, of pa-tients with functional articulation disorders (FAD). Methods 107 patients with FAD were observed of the clinical characteristics of/l/. 30 pa-tients with/l/articulation disorder accepted speech training. The correlation and simple linear regression analysis were carried out on/l/ar-ticulation disorders and age. Results The articulation disorder of/l/ mainly showed replacement for/n/,/y/,/r/,/d/ or omission. When/l/combined with vowels contained/i/and/ü/, the main error was omission. When/l/combined with vowels contained/a/,/o/,/e/or/u/, the er-rors trended to be replacement rather than omission. After speech training, the patients made less mistakes about/l/(P<0.001). The frequen-cy of/l/articulation disorders was negatively correlated with age (r=-0.840). The result of simple linear regression analysis showed that the determination coefficient was 0.422. Conclusion The/l/articulation disorder mainly shows replacement or omission, varied with the vow-els. The targeted rehabilitation training may be helpful. Age plays an important role in the outcome of/l/articulation disorder.

[Summary] Clinical studies have confirmed that metabolic surgery is an effective method for the treatment of diabetes ,which can significantly relieve symptoms of type 2 diabetes ,improve various complications and reduce cardiovascular events. Currently ,major limitations of this technique in clinical practice in China include the lack of understanding on surgical benefits ,difficulty in selection of surgery indications and division‐based treatment modalities. Thus ,we should explore a cooperation model of multi‐discipline teams ,understand the mechanisms of type 2 diabetes remission by metabolic surgery and develop physician internist leading standard post‐operation management. These strategies will greatly promote the development of metabolic surgery for type 2 diabetes in China.

Objective To investigate the influence of the diabetes with hypertension on glucose and lipid metabolism as well as renal function. Methods 310 diabetic inpatients were divided into hypertension group (n=150) and non-hypertension group (n=160). The levels of plasma glucose, insulin, C-peptide, lipid and creatine, as well as microalbuminuria were measured. The results were statistically analyzed. Results Compared with non-hypertension group, in hypertension group the plasma levels of fasting glucose and postprandial glucose significantly increased (P

OBJECTIVE: To facilitate the modernization of traditional Chinese medicine.METHODS: The connotation of good quality management norms of traditional Chinese medicine such as GAP was analyzed,and the strategies for the sound development of the modernization of traditional Chinese medicine were discussed. RESULTS & CONCLUSION: To facilitate the modernization of traditional Chinese medicine under the guidance of good quality management norms can promote the source innovation of technology of traditional Chinese medicine,speed up the internationalization of traditional Chinese medicine and promote it to a new step.