Objective To study the clinical characteristics and method of diagnosis and treatment of(nonfunctioning) parathyroid cysts(NFPTC).Methods The clinical data of 15 cases of nonfunctioning(parathyroid) cysts admitted in the recent 16 years were retrospectively analyzed.Results None of the cases were diagnosed before operation,and the diagnosis of all of the cases was verified by pathology.All of the(cases) were cured by operation.Follow-up found no case with recurrence.Conclusions Pathologic(examination) is the most reliable diagnostic method for NFPTC.Needle aspiration of fluid to test for PTH or(cytology) is an important method in diagnosis before operation.Surgical resection is the most ideal method of treatment.

In order to discover the steroid biotransformation ability of filamentous fungus Aspergillus niger TCCC41650, we studied the fermentation of 4-androstene-3,17-dione with A. niger TCCC41650. The transformation product was purified, crystallized and determined as 16β-hydroxy-androst-4-ene-3,17-dione by X-ray single crystal diffraction method. The best fermentation condition was found to be pH 6.0, ethanol amount 2% with a substrate concentration of 1 per thousand, the transformation rate is 85.81% after 72 h. Based on the best of our knowledge, 16β-hydroxylation rarely occurs in microbial transformations of steroid. This study laid the foundation for the research of 16β-hydroxylation steroids
Androstenedione ; metabolism ; Aspergillus niger ; metabolism ; Biotransformation ; Fermentation ; Hydroxylation ; Industrial Microbiology