Objective To investigate the correlation of triglyceride/high-density lipoprotein cholesterol(TG/HDL-C),triglyceride-glucose index(TyG)and derivatives with carotid atherosclerosis(CAS)in pa-tients with impaired glucose tolerance(IGT).Methods Clinical data of totally 102 IGT patients admitted to Tongling Hospital of Traditional Chinese Medicine from March 2021 to March 2023 were retrospectively ana-lyzed.Patients were classified into CAS group and non-CAS group according to the presence or absence of CAS.Univariate and multivariate Logistic regression models were utilized to testify whether TG/HDL-C,TyG and derivatives were responsible for CAS in IGT patients,and receiver operating characteristic(ROC)curve was plotted,then Spearman correlation coefficient was calculated to verify the correlation of TG/HDL-C,TyG and their derivatives with carotid intima-media thickness(IMT).Results There were 57 patients with CAS and 45 patients without CAS,with an incidence of 55.88％.There were statistically significant differences in age,high density lipoprotein cholesterol(HDL-C),triglycerides(TG),body mass index(BMI),TG/HDL-C,waist hip ratio(WHR),IMT between the two groups(P＜0.05).The TyG and derivatives in the CAS group were higher than those in the non-CAS group,and the differences were statistically significant(P＜0.05).TG/HDL-C,TyG and derivatives were positively correlated with IMT(both P＜0.05).Age,TG/HDL-C,WHR,TyG and derivatives were the factors influencing the occurrence of CAS in IGT patients(P＜0.05).The cut-off values of TG/HDL-C TyG were 1.04 and 9.10,the area under the curve(AUC)of the combined prediction for the CAS in IGT patients was 0.920(95％CI:0.865-0.974),which was larger than that of sin-gle prediction[0.831(95％CI:0.749-0.913),0.737(95％CI:0.641-0.833)].Conclusion TG/HDL-C,TyG and derivatives in IGT patients are closely correlated with IMT,which have a certain value in predicting CAS.Besides,age,TG/HDL-C,TyG and derivatives,and WHR are the influencing factors for the occurrence of CAS in IGT patients.

Objective To analyze thoracolumbar vertebral fractures(A3)treated by multiple manipulations using the finite element method and to explore the feasibility and advantages of the composite surgical method for treating thoracolumbar vertebral fractures(A3).Methods For three-dimensional reconstruction of thoracolumbar vertebral fractures(A3),the model was loaded with simulated hyperextension posture restoration,simple press restoration,press restoration under hyperextension posture,and composite manipulation.Subsequentially,the stress distribution of the model and displacement of the fractured vertebral body were observed.Results The equivalent stress under composite manipulation was 111.88 MPa,which was greater than that under other manipulations,and the stress under composite manipulation was more concentrated in the anterior and middle columns of the vertebral body.The peak stress under composite manipulation was 122.53 MPa,which was greater than that under other manipulations,and the stress was centrally distributed in fracture region of the fractured vertebral body.The fracture displacement under composite manipulation was 3.94 mm,which was greater than that under other manipulations,and the displacement distribution decreased from the posterior column to the anterior mid-column.The anterior longitudinal and intertransverse interligamentous ligaments of the fractured vertebral body experienced the greatest stress under composite manipulation,and the joint capsule ligaments experienced the greatest stress under hyperextension postural restoration,simple press restoration,and press restoration under the hyperextension posture.Conclusions Compound manipulation for treating thoracolumbar vertebral fractures(A3)has obvious advantages over other manipulative restorations and is a reasonable program for the current treatment of thoracolumbar vertebral fractures(A3).