Objective To sum up Pro. Wei Yuegang's clinical experience in treating psoriasis vulgaris of hot blood syndrome. [Method] By analysis to classical recipe cases, it states Pro. Wei's differentiation thought and clinical medication experience in treating psoriasis vulgaris of hot blood. [Result] In the mechanism of the disease, the location is in blood, in the first stage, it shows hot blood mainly; the clinical treatment centers on “clearing heat to cool blood and remove toxin”in the development stage, by using his own“Liangxue Jiedu Drink”. In the case here, the patient basical y disappeared the acne, his al symptoms were relieved. [Conclusion] Pro. Wei Yuegang has good cure effect on treating psoriasis vulgaris of hot blood with differentiation of signs, with guiding meaning to practical clinic.