Objective To evaluate the efficacy of bevacizumab combined with chemotherapy in the treatment of advanced colorectal cancer. Methods 100 cases of patients with advanced colorectal cancer from March 2015 to December 2016 in our hospital were selected as the object, and randomly divided into observation group and control group, 50 cases in each group. Group A was given routine chemotherapy, group B was given combined with chemotherapy and bevacizumab treatment, compared the two groups of patients with clinical efficacy. Results The total effective rate was 28.0％, group B was 54.0％, the difference between the two groups was statistically significant (P<0.05). Conclusion Combined chemotherapy and bevacizumab is effective in the treatment of advanced colorectal cancer and is worthy of promotion.

Objective To study the changes of tartrate resistant acid phosphatase in the serum of patients with bone metastasis in pros-tate cancer,and to explore its clinical significance for bone metastasis diagnosis and prediction of prostate cancer. Methods Seventy-eight cases of prostate cancer and 40 cases of benign prostatic hyperplasia patients as the research object,at the same time,40 healthy young men as controls,were divided into the group of patients with prostate cancer bone metastases (group A,n=41),prostate cancer patients with no bone metastasis group (group B,n=37),benign prostatic hyperplasia patient group (group C,n=40),healthy control group (group D,n=40). Determination of serum TrACP levels in patients with the immunoassay using double antibody sandwich ELISA,combined with pathologi-cal grade,Gleason score,PSA,ALP and ALT were statistically analyzed. Results The serum TrACP concentration in patients with bone me-tastasis significantly increased,with significant difference compared with the other groups. The concentration of serum TrACP and PSA levels showed a positive correlation. The area under the ROC curve ( AUC) was higher than that in ALT,and the ROC curve of cross TrACP and PSA,suggesting that high value in the diagnosis of bone metastasis. Conclusion The detection of TrACP has directly diagnosis and predic-tive value for prostate cancer with bone metastasis,the serum TrACP content monitoring in patients with prostate cancer has valuable clinical significance in understanding the growth progression status of prostate cancer,judgment and prediction of bone metastases.

Salivary gland obstruction is a commonly disorder affecting this organ usually due to the development of salivary calculi, ductul srictures, or both. Imaging plays an important role in the diagnosis of the cause, extent, and effects of the obstruction. Up to date, the micro-invasive interventional treatment is always be taken as the first method of choice for dislodgment of calculi and sacculus salivary sialodochoplasty through buccal cavity. This article gives a comprehensive review of the indications and technical procedure.

Using Response Surface Methodology (RSM), an optimizing model of concurrent parameter and tolerance design is proposed where response mean equals its target in the target being best. The optimizing function of the model is the sum of quality loss and tolerance cost subjecting to the variance confidence region of which six sigma capability can be assured. An example is illustrated in order to compare the differences between the developed model and the parameter design with minimum variance. The results show that the proposed method not only achieves robustness, but also greatly reduces cast. The objectives of high quality and low cost of product and process can be achieved simultaneously by the application of six sigma concurrent parameter and tolerance design.

Objective To investigate the treatment of the lower extremity deep venous thrombosis .Methods Sixty patients with lower extremity deep venous thrombosis were analyzed retrospectively .Thirty two patients underwent reteplase thrombosis ,and 28 patients underwent recombinant streptokinase thrombosis ;the effects of each group were compared;and the various complications and adverse events were observed .Results Patients in two groups were all effectively treated ,and the effective rate of reteplase group was higher than recombinant streptokinase group (P<0 .05) .The adverse rate of reteplase group was lower than recombi‐nant streptokinase group ,but there was no significant difference between two groups (P>0 .05) .During the follow‐up ,there was no reoccurrence in all 60 patients .Conclusion Reteplase thrombolytic therapy for the lower extremity deep venous thrombosis is safe and effective .

OBJECTIVE To explore the value of molecular epidemic technology on tuberculosis outbreak in prison.METHODS Using mycobacterial interspersed repetitive unit(MIRU) genotyping to discriminate and recognize 7 strains on tuberculosis cases.RESULTS Among 7 Mycobacterium tuberculosis isolates,6 strains′ MIRU genotyping was 233325153533,another one was 242325152322.Six M.tuberculosis cases were infected by the same MIRU genotyping tuberculosis strains,but another one was not.CONCLUSIONS MIRU genotyping to discriminate and track source of infection is possible.

Implant performance is closely related to the load transmission at the bone-to-implant interface where bone quality will be highly variable.It has been demonstrated that poor quality bone is associated with high failure rates.To date,Digital Radiography,Dual energy X-ray absorptiometry and Computed tomography scan technique have gained increasing popularity for precise evaluation of the dental implant field in clinic,which would enable the surgeons to predict implant properties and immediate loading capacity before surgery.Individual preoperative measurements of local bone mineral density could be used to determine the best suited implant sites and types and optimize the prosthetic plan accordingly,which has important significance in the prognosis of the dental implants.

Objective We aimed to study the characteristics and risk factors for blood transfusion in very low birth weight infants (VLBWI). Methods Clinical data of 180 VLBWI, hospitalized from January, 2012 to June, 2016, were studied retrospectively. The infants were divided into two groups according to whether blood transfusion is administered or not. Two groups were compared with general information, diseases in hospital and treatment taken. Results Of the 180 VLBWI, 118 cases (65.6%) were diagnosed with anemia when hospitalized. 57 cases (31.7%) needed blood transfusion with a mean gestational age of 30.3±1.9 weeks and a mean birth weight of 1233.3±123.7 g, The first time to blood transfusion ranged from 2 to 5 weeks after birth, transfusion volume 20ml/Kg once. Fourty-eight (48) cases (84.2%) only took blood transfusion once. Birth weight, gestational age, basal hemoglobin, hematocrit, volume of blood taking before transfusion, duration of hospitalization, duration of continuous positive airway pressure, duration of paraenteral nutrition, duration of vasoactive drugs used, need for intubation、delivery mode, neonatal respiratory distress syndrome, apnea, neonatal hypothyroidism and patent ductus arteriosus showed significant difference between the two groups. Logistic regression analysis revealed that gestational age, birth weight, basal hemoglobin, long duration of hospital stay and blood loss from laboratory testing were risk factors for blood transfusion in VLBWI (P<0.05). Conclusions The rate of blood transfusion in VLBWI was relatively high. Complex complications, critical condition, blood loss from laboratory testing and basal hemoglobin were main risk factors for blood transfusion.

Objective To measure the course of the mandibular canal in mandibula posterior area by cone-beam computed tomography ( CBCT ) , to provide a theoretical support for implant preoperative assessment. Methods Mandibular data of 65 people measured by CBCT were collected, measured the distance between mandibular canal around the bone wall and analyzed the differences by gender and the differences between the left and the right. Results The average distance of mandibular canal outer edge to the buccal bone plate by former backward in-creased gradually,at least in the area of the mental formen, at largest in the area of the mental foramen after 18 mm. The average distance between mandibular canal inner edge to lingual bone plate by former backward reduced gradually, at largest in the area of the mental foramen,at least in the area of the mental foramen after 18 mm. The average distance between mandibular canal upper edge to alveolar crest by former backward reduced gradually,at largest in the area of the mental foramen, at least in the area of the mental foramen after 18 mm. The average dis-tance between the edge of mandibular canal to the edge of mandible by former backward reduced previous,then in-creased, at least in the area of the mental foramen after 6 mm, at largest in the area of the mental foramen after 18 mm. All the results had no significant statistical differences between the male and the female, and had no significant statistical differences between the left and the right. Conclusion The trajectory of the mandibular canal from front to back is downward first, then upward in the mesial of the first molar in the vertical, and whose from the buccal side to the lingual side. That has significance for assessment before implant in mandibular posterior area.