1.Clinical analysis of 39 cases with reoperation for thyroid
Han DENG ; Chuang TONG ; Jianguo WANG ; Jun CAO ; Zhiguo WU
Chinese Journal of Primary Medicine and Pharmacy 2014;(14):2099-2101
Objective To explore the cause of the thyroid reoperation ,methods,surgical approach ,and the prevention of complications .Methods 39 cases of thyroid reoperation in patients with clinical data were reviewed and analyzed.Results Thyroid papillary carcinoma in 11 cases,follicular carcinoma in 2 cases,nodular 22 cases of thyroid,thyroid adenoma 1 case,3 cases of primary hyperthyroidism .The incidence of transient hypoparathyroidism ac-counted for 2 cases,temporary laryngeal recurrent nerve injury in 2 cases,chyle leakage in 1 case,in total of 12.8%of postoperative complications .Conclusion Improper operation method choice for the first time and the misdiagnosis was the main cause of reoperation , The reoperation of thyroid is difficult and has more complications .Preoperative evaluation and careful operation can prevent the occurrence of complications .
2.Clinical characteristics of liver function damage in patients with brucellosis
Lihong HAN ; Zhiguo LIU ; Yonghua LIU ; Rihong LIU
Chinese Journal of Endemiology 2015;34(5):373-375
Objective To study the characteristics of liver function damage in brucellosis and provide theoretical basis for clinical treatment.Methods One hundred and thirty-six hospitalized patients with brucellosis from Endemic Disease Prevention and Control Center of Wulanchabu City from January 2011 to October 2012 were selected randomly as the research subjects.Parameters of Alanine transaminase (ALT),Aspartate transaminase (AST),Alkaline phosphatase (ALP),Gamma glutamyltransferase (γ-GT),Total protein (TP),Albumin (ALB),Albumin/globulin (A/G),total bilirubin (TBIL) and Direct bilirubin (DBIL) were determined.The means of liver function parameters with mid-value of all the reference ranges were compared by one sample t test;Parameters of liver function were analyzed in 70 acute and 66 chronic brucellosis by two independent-samples t test.Results The means of ALT,AST,ALP,γ-GT,TP,ALB,TBIL and DBIL ((x):36.18,28.20,95.87,29.29 U/L,65.08,40.84 g/ L and 19.76,5.86 μmol/L) in the 136 samples of brucellosis serum were significantly different from the medians of their reference ranges ((x):20.50,18.50,85.00,24.50 U/L,69.00,43.50 g/L and 11.80,3.40 μ mol/L,t =9.46,9.19,4.55,2.22,-2.71,-4.99,5.58,11.32,all P < 0.05);A/G was not significantly different ((x):2.14,2.00;t =0.94,P > 0.05);Parameters of liver function were not significantly different between acute and chronic brucellosis (all P > 0.05).Conclusions This study confirmed that the liver function of the 136 patients with brucellosis is impaired.The level of the liver function impairment is usually mild and moderate and no difference in acute and chronic brucellosis is found.
3.The association between the Uygur patients with schizophrenia and CMYA5 polymorphism
Xiao LUO ; Lili ZHANG ; Shuxian HAN ; Zhiguo AN ; Qizhong YI
Chinese Journal of Nervous and Mental Diseases 2014;(12):726-730
Objective To investigate the association between Cardiomyopathy associated 5 (CMYA5) polymor?phisms and schizophrenia in the Uygur Chinese population. Methods Taq-man assay was used to detect CMYA5 gene rs3828611 in 684 schizophrenia patients and 678 healthy controls from Chinese population. The positive and negative symptoms scale (PANSS) was used to evaluate patients’symptoms. Results Neither the genotype nor the allele frequen?cies of rs3828611 was significantly different between the patients and the controls (P>0.05). The differences were not sig?nificant in either each gender subgroup or in each age (teenager and adult) subgroup (P>0.05). The total score and the sub scores of PANSS were not significantly different among patients with different genotype groups (P>0.05). Conclu?sions There is no association between CMYA5 rs3828611and schizophrenia in the Uygur Chinese population.
4.Measurements and characteristics of external nose-related parameters in normal Uygur people
Jinshan LU ; Aiweiroula ZAINULA ; Zhiguo HAN ; Zhaohui SONG
Chinese Journal of Medical Aesthetics and Cosmetology 2014;20(5):324-327
Objective To measure and analyze the external nasal morphology of normal Uygur in Xinjiang,which will provide the anatomical basis for the rhinoplasty.Methods From the Department of Otolaryngology and Plastic Surgery of our hospital,we collected the Uighur patients' families as the research objects during January 2011 to December 2012,and at the same time Han nationality patients' families were set as control group.Related parameters of external nose measurements were completed,and the parameters of external nose of 95% confidence interval calculated,and compared with those of Han people.Results The measured data showed that there were the 95% confidence interval of the Uighurs external nasal related indicators; The nasal length,height,depth,dorsum slope length,temples,nasal tip angle of the male Uighur were greater than those of male Han; Uighur women had longer,higher nose,more slope length of the nose back,and greater nasal-facial angle and nosewing angle than that of Han women.The proportion of ultra narrow nasal type,narrow nose,the middle nose in Uighur men was 14.02%,79.50%,and 6.48% ; that in Uighur women was 14.60%,67.72%,and 17.68%,respectively; compared with those in Han nationality,there was a significantly statistical difference (P<0.05).Conclusions The external nasal morphology of the Uygur people in Xinjiang has its characteristics,with dominants of narrow nasal type; 95% of medical reference range will provide an objective reference basis for the future clinical work.
5.Avian influenza virus surveillance in external environment in Urumqi City during 2013 to 2015
Zhiguo HAN ; Feng GAO ; Na XUE ; Xucheng FAN
Chinese Journal of Microbiology and Immunology 2017;37(6):457-460
Objective To investigate the distribution of avian influenza A viruses in external environment in Urumqi City in order to provide reference for the prevention and control of human infection with avian influenza virus in Urumqi City.Methods Environmental specimens were collected from 2013 to 2015 to detect avian influenza A virus nucleic acid with real-time fluorescent PCR.The positive specimens were further analyzed to identify the subtypes of avian influenza A viruses.Results A total of 1 043 environmental specimens were collected and tested.Among them,123 specimens were positive for avian influenza A virus nucleic acid with an overall positive rate of 11.79%.H9 was the predominant subtype,accounting for 7.77% of all specimens.Quarterly detection rates of avian influenza A virus in the three years peaked in different quarters of the year.Of all surveillance sites,live poultry markets in urban and rural areas had the highest positive rate (14.23%).Specimens collected from poultry drinking water (18.44%) and other specimens (19.44%) were highly positive for avian influenza A virus.Conclusion Avian influenza A viruses,especially the subtypes of H5,H7 and H9,exist in live poultry markets in Urumqi City.It is necessary to conduct surveillance and health education among people exposed to poultry in live poultry markets.
6.MRI Diagnosis of Ligament Trauma of Knee
Jie LEI ; Haishan YANG ; Zhiguo HAN ; Chuanyu CUI
Journal of Practical Radiology 2010;26(1):60-62,70
Objective To evaluate the value of magnetic resonance imaging(MRI) in diagnosing ligament injury of the knee.Methods MRI manifestations of ligament injury of the knee confirmed by operation or joint-screen examination in 32 cases were retrospectively analyzed. All cases underwent routine MR scanning. The cases with suspicious anterior cruciate ligament injury undenwent oblique saqittal section fast spin echo-T_2 weight (FSE-T_2WI )and the cases with suspicious medical accessory ligament injury underwent coronal section fat suppressed-fast spin echo-T_2 weight(FS-FSE-T_2W).Results 36 ligaments were found having injury in all cases, including 16 anterior cruciare ligaments, 14 posterior cruciate ligaments, 5 medical accessory ligaments and 1 lateral accessory ligament. The ligaments injuries included tear completely and part.Conclusion MRI is the ideal non-invasive method for studying ligament injury of the knee.
7.New Technology in Design of Electrical System for Medical Vehicle
Xiangdong CUI ; Zhiguo LIU ; Jinggong SUN ; Junshu HAN
Chinese Medical Equipment Journal 1993;0(06):-
The characteristics and developing trends of electrical system for medical vehicles are introduced.Key techniques in electrical system design are put forward.Emphasis is put on application of new technologies to electrical system for medical vehicles.By using some new techniques in design of medical vehicles,the performance of vehicles is improved in a certain extent.
8.Fuzzy clustering analysis of inorganic elements in traditional Chinese medicines cured for vascular disease
Shunfu DONG ; Liqin HAN ; Zhiguo ZHU ; Zhonghang CHEN ; Hongbo DONG ;
Chinese Traditional Patent Medicine 1992;0(04):-
Objective: To apply fuzzy clustering analysis to determination of 10 inorganic elements and Cu/Zn ratio in 13 kinds of traditional Chinese medicine cured for vascular disease. Methods: By FAAS (flame atomic absorption spectrometry) sodium, calcium, magnesium, potassium, iron, chromium, nickel, manganese, copper and zinc were determined. By range analysis, correlation coefficients and relative fuzzy matrix were calculated.Results: Correlation coeffieients ? were mostly in the range of 0.55~0.80, especially ?=0.95 between Buzhangnaoxintong Capsule and Xinbao Pill. Conclusion: On condition that trace and macro elements are relatively rich and clustering correlation coefficients are larger, therapentic effects among traditional Chinese medicines cured for vascular disease are also similar. This suggests that trace elements, macro elements and Cu/Zn ratio have much to do with therapeutic effect.
9.Clinical study of different doses of oxycodone for severe pain in cancer patients
Wenwen LI ; Lei HAN ; Zhiguo ZHANG ; Li LI ; Hongwei GUO ; Pei XUN ; Jian LUO
Journal of Chinese Physician 2016;18(1):22-25
Objective To investigate the optimal dose of oxycodone for severe pain in cancer patients so as to try to alleviate the suffering rapidly.Methods Totally 135 cases with severe pain in terminal cancer patients were randomly divided into groups A,B,and C,45 cases in each group.Groups A,B,and C were treated with oxycodone hydrochloride sustained-release tablets 20 ~ 140 mg/d,150 ~ 290 mg/d,300 ~ 640 mg/d,respectively.Pain relief and incidence of adverse reactions were evaluated 2 weeks later.Results Pain intensity scores (numerical rating scale,NRS) in 3 groups dropped with statistical difference (P < 0.05).Pain relief rates in groups B and C were statistically significant compared to group A (P < 0.05).Quality of life score (appetite,mental status,sleep,daily activities,and interpersonal life) in group C had statistical significance compared to groups A and B (P < 0.05).Group C had slightly higher incidence of adverse reactions than that of groups A and B without significant difference (P > 0.05).Conclusions Large dose and extra large dose of oxycodone hydrochloride sustained-release tablets can effectively relieve severe pain in advanced cancer patients.Extra large dosage can improve patient's quality of life in spite of the higher incidence of adverse reactions,and patients can still be tolerated well.
10.Association analysis of the rs10043986 polymorphism of cardiomyopathy-associated 5 gene with schizophrenia in Uygur Chinese population
Shuxian HAN ; Zhiguo AN ; Lili ZHANG ; Jiangtao WANG ; Xiao LUO ; Wen DU ; Qizhong YI
Chinese Journal of Behavioral Medicine and Brain Science 2015;24(1):27-30
Objective To evaluate the relationship between cardiomyopathy-associated 5 (CMYAS) gene rs10043986 polymorphism and schizophrenia in Uygur Chinese population.Methods The SNP rs10043986 in CMYA5 gene was genotyped in 325 patients with schizophrenia and 183 normal controls using TaqMan technology.The symptoms of schizophrenia were assessed by positive and negative syndrome scale (PANSS).The association of the loci with schizophrenia,age of onset,clinical symptom was analyzed.Results The allelic and genotypic distributions in rs10043986 between patients with schizophrenia (C,T allele:91.5%,8.5% ; C/C,C/T,T/T genotypes:83.4%,16.3%,0.3%) and normal controls (C,T allele:96.4%,3.6% ; C/C,C/T,T/T genotypes:92.9%,7.1%,0) had statistically significance after analysis (x2 =9.038,P=0.003 ; x2 =9.417,P=0.009).Via analysis of stratification by gender and age at onset.The results showed that both allele (x2=11.812,P=0.001) and genotype (x2=12.769,P=0.001) frequency in rs10043986 with patients were significantly different in females,but neither in males (all P>0.05).Allelic or genotypic distributions between adult cases and controls had statistically significance (x2=8.219,P=0.004; x2=8.379,P=0.015),but there were not significant differences between adolescent cases and controls (all P> 0.05).Furthermore,we also notice that the PANSS scores of patients between Genotype C/C and C/T had no statistically significance (allP>0.05).Conclusion The results reveal that T allele at CMYA5 rs10043986 may be confer risk for susceptibility of female and adult schizophrenia in Uygur Chinese population,and that rs 10043986 polymorphism may not significantly associate with symptoms severity of schizophrenia.