Objective To invastigate the effect of living donor liver transplantation(LDLT) with middle hepatic vein(MHV) and LDLT without MHV on the donor. Methods Between August 2007and August 2008, 62 LDLT were performed, 30 LDLT with MHV (group A), 32 LDLT without MHV (group B). Before operation, comprehensive assessment the graft size, remnant liver volume (RLV), fatty liver, MHV type, and the level of portal hypertension in recipient to determine whether harvested MHV. The graft was harvested depending on the port vein and hepatic artery ischemia-line,ultrasound was used to definite the branch of MHV. The donor operative time, intraoperative blood loss, postoperative hospital stay, bilirubin, INR, ALT, albumin, and complications were recorded in detail. Results Operative time, blood loss, hospital stay between group A and group B were not significant difference. But the bilirubin, INR, ALT in group A was higher than group B; Albumin recovered slower and with more ascites in group A. The early complications post-operation were similar in the two groups. There were 2 cases with wound infection in group A and 3 in group B. 3 cases complicated with cholestasis in group A and 1 case in group B, all of them gradually recovered to normal after 2 weeks. 2 cases occurred cross-section bile leakage in either group, the patients administrated with anti-infection, external drainage and recovered;4-7 days after operation, there were 6 cases in group A and 5 cases in group B occurred delayed gastric emptying, it was alleviated after adjust diet, encouraging activities and administrated with gastrointestinal motility drugs. Conclusion Right graft with the middle hepatic vein may lead donor recovery delayed, but with precise evaluation, especially MHV type, remnant liver volume (RLV%)＞30%, preserve the drainage of V4b and the artery segment Ⅳ,it's can ensure the donor's safety.

Objective:To investigate the long-term survival rate and the influencing factors for prognosis in patients aged 80 years and over who underwent hemodialysis.Methods:Clinical data of 82 patients with end stage renal disease (ESRD) who started dialysis in≥80 years of age and underwent hemodialysis for more than three months in our hospital from May 2008 to May 2017 were retrospectively analyzed.Kaplan-Meier method was used to analyze the survival rate of patients.Log-rank test was used to compare survival rate of hemodialysis patients aged≥80 years versus aged<80 years.Cox regression model was performed to analyze the influencing factors for prognosis in elderly patients undergoing hemodialysis.Results:The median survival time of 82 hemodialysis patients aged≥80 years was 34 months, and their 6-month, 12-month, 24-month and 36-month survival rates were 90.0%, 73.6%, 60.8% and 49.4%, respectively.The top three death causes were cardiovascular events, septic shock, and malignant tumors.The median survival time of the hemodialysis patients aged<80 years was 52 months, and their 6-month, 12-month, 24-month and 36-month survival rates were 94.7%, 85.5%, 72.4% and 65.8%, respectively.Log-rank test demonstrated that the survival rate was lower in patients aged≥80 years than in patients aged<80 years( χ2=5.284, P=0.022). Multivariate Cox regression analysis indicated that diabetes mellitus was an independent risk factor for the survival in hemodialysis patients aged≥80 years( HR=3.470, 95% CI: 1.364~8.827, P=0.009), while targeted levels of body mass index(BMI)( HR=0.806, 95% CI: 0.706~0.921, P=0.001)and serum albumin level( HR=0.861, 95% CI: 0.789~0.938, P=0.001)were the independent protective factors for the survival in hemodialysis patients aged≥80 years. Conclusions:The survival rate is lower in hemodialysis patients aged≥80 years than in those aged<80 years.The top death causes is cardiovascular events, septic shock, and malignant tumors.Diabetes mellitus, low levels of BMI and serum albumin are the main risk factors for the survival in advanced elderly patients undergoing hemodialysis.

Objective: To analyze the performance of the 5 Global Fund Malaria Programmes in China from 2003 to 2013. Methods: All of the proposals, summaries, progress reports, survey reports, Monitoring& Evaluation reports, and performance rating reports of the 5 Global Fund Malaria Programmes in China and the epidemic data of program areas were collected for statistical analysis from 2012 to 2014. Symposiums were held with relevant experts from national and provincial Centers for Disease Control and Prevention, program managers and staffs from national and provincial Global Fund Malaria Programme offices. The completion of the relevant programme indicators (including the general grant information such as program areas, beneficiaries and funding; the implementation of malaria control measures; the performance of malaria control measures; the malaria incidence in the program areas; the prevalence of malaria parasites; and program management and performance evaluation) were analyzed, and the results: of the symposiums were summarized. Results The implementation period of the 5 Global Fund Malaria Programs were as follows: Round 1 from 2003 to 2008, Round 5 from 2006 to 2010, Round 6 from 2007 to 2012, Round 10 from 2012 to 2013, and National Strategy Application (NSA) from 2010 to 2012. Under the support of all the Global Fund Malaria Programs, a total of 11 936 726 fever cases received microscopic tests, 1 485 915 confirmed and suspected malaria cases were treated, 1 579 773 Long Lasting Insecticide-treated Nets were distributed, 3 414 633 regular nets were treated by insecticide, 40 298 284 primary and middle school students received health education on malaria control. Compared with the baseline value, the completion rates of each indicator increased after the implementation of the programs. The growth value ranged from 12.83% to 83.11%, among which the biggest growth was the value of the indicator'Percentage of households with at least one LLIN/ITN in target areas’, and it increased from 9.2% (baseline value of 2006) to 92.31% (value of 2012). The malaria incidence in program areas has dropped significantly year by year, the annual reported malaria incidence in Yunnan and Hainan provinces decreased from 1 950/100 000, 3 850/100 000 in 2002 to 3.31/100 000, 0.15/100 000 in 2012, the P. falciparum malaria incidence in target counties in Hainan province decreased from 90.6/100 000 in 2002 to 0/100 000 in 2012. As from the implementation of NSA grant in 2010 to 2012, the annual reported malaria incidence in 92% of the 75 Type 1 counties was less than 1 per 10 000, 60.00% of Type 1 counties and 98.69% of the 687 Type 2 counties reported zero locally transmitted malaria cases. The Global Fund Secretariat had conducted a total of 37 performance evaluations, of which 9 have been rated as A1, 4 rated as A2, 19 rated as B1 and 5 rated as B1. Conclusions The Global Fund Malaria Program in China has been closely integrated with the goal and task of National Malaria Control Program, reducing malaria burden in target areas, and pushing Chinese malaria control efforts to move from control to elimination.

With the gradual resumption of international travel, cross-border population movement has become frequent again, risk assessment of imported malaria has important public health significance to maintain malaria elimination status in China. Currently, risk index system construction method, risk index method, mathematical model method, and infectivity-receptivity- vulnerability method are mainly used in imported malaria risk assessment in China. This paper summarizes the common evaluation methods in the risk assessment of imported malaria research in China to provide references for the further research.