OBJECTIVE: To analyze the drug use in outpatient and emergency departments of our hospital.METHODS: A total of 12 000 prescriptions in outpatient and emergency departments in 2006 were randomly sampled for the analysis of drug use.RESULTS: 43% of the drugs were used singly and 13% were combined use of 4 or more than 4 drugs.Oral administration and intravenous injection were the leading routes of administration.3.10% of the prescriptions were irrational in dosage,repeated drug use,dosage regimen,use of dissolvants,drug combination,and drug choice etc.CONCLUSION: The drug use in the outpatient and emergency departments of our hospital were rational basically,yet there are still some problems remains to be tackled.Great importance should be attached to the prescription check.

OBJECTIVE: To develop a new type of injectable sustained thermosensitive meloxicam hydrogel.METHODS: Injectable thermosensitive meloxicam hydrogel was prepared with chitosan-glycerin-borax as carrier.The influence factors of hydrogel were studied such as preparation temperature,pH value,the ratio of glycerin to chitosan.In vitro release of samples was also evaluated.RESULTS: Optimal preparation condition was as follows: preparation temperature was 37 ℃ with pH value of 7.0 and the ratio of glycerin to chitosan was 3 ∶ 10.Mean accumulative release of samples was 76% within 288 h.CONCLUSION: Established method is simple and preparation is characterized with high temperature sensitivity and sustained-release.

Objective To analyze youth talents' scientific research projects in research oriented hospital for recent five years,provide scientific basis for hospitals to strengthen the youth talents' capacity building of research innovation.Methods Identify those youth talents who have been funded in the First Affiliated Hospital of Xinjiang Medical University,and statistically analyze the demographic information,granted scientific research projects and hospital funding situations.Results There are 140 young talents who have got scientific research projects from 2011 to 2015 in the hospital.The national project number and the trend of approval rate has no obvious change;the provincial level project number and approval rate showed a trend of a significant increase in the last two years;Setting up the hospital fund promoted the youth talents' scientific research ability,but there are still spaces for further improvement in the funding field and founded group.Conclusions There has been a group of youth talents to stand out from the crowd during the construction and the development of the researchoriented hospital,but youth talents remains scarce for the national key projects and talent projects,and that will put forward new requirements for the hospital in the future to strengthen the youth talents' capacity building of research innovation,which needs to gradually establish a suitable cultivation mode and mechanism for youth talents' growth.

OBJECTIVE:To facilitate the evolvement of hospital pharmaceutical care.METHODS:The website of pharmacy department of Shanghai No.9People’s Hospital was programmed and exploited,and based on which the hospital pharmaceutical information service was carrying out.RESULTS:The website ran stably and fast;its maintenance was very convenient;pharmaceutical information was rich,the online communication between doctors and patents was available here and the application outcome proved to be satisfactory.CONCLUSION:Establishing hospital pharmaceutical website and carrying out online pharmaceutical care are of significance in the evolvement of hospital pharmacy work.

Objective Though the research on the satisfaction of environment and factors influ encing the growth of the talented in medical science in Xinjiang,the author focuses on the shortcomings and reasons of current development of the talented,and provides specific suggestions and improvement for the cultivation of the talented.Methods Using Xinjiang Medical University First Affiliated Hospital as the research object,author investigates the influential factors of growth,and the satisfaction of environment though the questionnaires.Results According to the principal components analysis,the factors which influence the growth the talented in medical science are put in flowing order:political factor＞environmental factor＞education factor＞family factor.According to the data envelop ment analysis,in the satisfaction of environment of hospital technological innovation,the talented in hospital technological innovation consider that the cultivation plan,research expenses,support for scientific research,recruitment,and social welfare are at a better satisfaction rate;but the duration of academic research,income policies,selection of the talented,and the outcome of the research are at a low satisfaction rate.Conclusions Based on the current development and cultivation of the talented in the innovation of medical science,there are still many shortcomings.Hospital must continue interna tional cooperation,insist to do the cultivation of the talented and the innovation team,and complete the selection mechanisms,in order to give enough time for the scientific research,and create a good atmosphere of medical science innovation at the same time.Only when the services for the talented are well-prepared,Xinjiang medical science innovation can achieve enough support and motivation for the development of the talented.

Objective This study uses the KANO model to evaluate the satisfaction of the growth environment of medical science and technology innovation talents in Xinjiang,comprehensively understand the needs of talents for the growth environment,and propose specific countermeasures for the improvement and related direction of Xinjiang's science and technology innovation talent growth environment.Methods Science and technology innovation talents from three tertiary hospitals in Xinjiang were selected as research subject,questionnaire survey was conducted to understand their basic information,and to confirm the talents growth environment for the current attitude according to the structural KANO model questionnaire includes rules.Results The KANO model was used to determine five key indicators that have high sensitivity to the satisfaction of Xinjiang medical science and technology innovation talents.They are research funding,scientific research facilities,scientific research reward mechanism,scientific research team cooperation,and academic exchanges domestically and internationally.Conclusions According to the key influencing factors of Xinjiang medical science and technology innovation talent satisfaction,improving and optimizing the corresponding indicators can effectively improve the overall quality of the technological innovation talent growth environment and improve the satisfaction of scientific and technological talents.

Objective To determine the weights of performance appraisal indicators of autonomous regional attached re-search institute of medicine in Xinjiang .Methods The AHP analysis method was used to establish a judgment matrix ,which determined the corresponding weights of the factors ,and calculated the total weight coefficient of the indicators that constitute the performance evaluation system of autonomous regional attached research institutes of medicine .Finally ,consistency check was performed on the judgment matrix .Results The assignment of experts to each indicator was reasonable and effective ,and the comparison with each other of the relative importance of indicators was appropriate .The weight coefficients of the criteria layer respectively were 0 .09246 ,0 .20434 ,0 .17473 ,0 .23681 ,0 .29166 ,and the total weight coefficient of the indicators were calculated .A performance evaluation model of attached research institute of medicine in Xinjiang was constructed .Conclusions The performance appraisal system of autonomous regional attached research institute of medicine in Xinjiang established by the AHP analysis method had a high degree of credibility and operability ,which can be used as a reference for further strengthe-ning the management of the institutes .

CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs) have been shown to play a regulatory or suppressive role in the immune response and are possibly relevant to the pathogenesis of autoimmune diseases. In the present study, we attempted to investigate the frequency of CD4+CD25+ Tregs in peripheral blood (PB) of collagen-induced arthritis (CIA) rats during the development of arthritis, to determine whether their frequency is involved in the immunoregulation of this disease. The results showed that normal rats had similar frequencies of CD4+CD25+ Tregs in PB during the experiment time, expressed as a percentage of CD4+CD25+Foxp3+ T cells among the CD4+ T lymphocyte population. In contrast, the frequency of CD4+CD25+Foxp3+ T cells in CIA rats was found to change during the development of arthritis. In CIA rats, there is a significant negative correlation between the frequency of CD4+CD25+Foxp3+ T cells and paw swelling (r=-0.786, p< 0.01). The relationship between the frequency of CD4+CD25+Foxp3+ T and immune activation was not found in normal rats. During the time course, the frequency of CD4+CD25+Foxp3+ T was lower in CIA rats than in normal ones. The data suggest that the frequency of PB CD4+CD25+ Tregs may be a promising marker for arthritis activity.
Animals ; Arthritis ; Arthritis, Experimental* ; Autoimmune Diseases ; Lymphocytes ; Rats* ; T-Lymphocytes ; T-Lymphocytes, Regulatory*