Objective To explore the method of repairing foot soft tissue defects by using island skin flaps pedicled with sural nerves and vessels. Methods 24 patients with foot soft tissue defects were treated surgically. The defects were repaired with island skin flaps pedicled with ipsilateral sural nerves and vessels. Results Of all the 24 flaps, 21 flaps survived at the first intention. Partial necrosis appeared in 3 flaps but were cured at the second intention. The follow ups of 1 to 2 years showed that the appearance and function were satisfactory in all the cases except 4 in which the skin appeared swollen. Conclusion To repair foot soft tissue defects, this flap has the advantages of strong anti infection ability and good texture so that healing at the first intention and early functional recovery can be obtained.

Objective To explore the effect of oral mosapride on gastrointestinal transit time in elderly patients undergoing capsule endoscopy.Methods A total of 61 patients referred for capsule endoscopy during 2010 September to 2012 January were involved in this study.40 patients over 65 years old were prospectively randomized into mosapride citrate group (n=19) or non-mosapride citrate group (n=21).Patients under 65 years old were in control group (n=21).Mosapride citrate group took 10 mg mosapride citrate orally before endoscopy.The gastrointestinal transit time was calculated.Results Gastric emptying time and small intestinal transit time of patients over 65 years old were significantly shorter in mosapride citrate group than in non-mosapride citrate group [(48.6± 21.1) minand (64.3±22.4) min,t=2.274,P=0.029; (302.2±67.6) min vs.(347.14±51.18) min,t=2.384,P=0.022].There were on significant differences in gastric emptying time and small intestinal transit time between non-older group [(45.4 ± 28.4) min and (284.8 ± 78.3) min] and mosapride citrate group (t=0.407,P=0.686;t=0.751,P=0.457).There was a difference in the image score between medication group and no medication group (4.94±0.63 versus 4.50±0.68; t=2.137,P=0.039) in over 65 years old patients.Conclusions Mosapride may decreased the gastric emptying time and small intestinal transit time,improves the capsules endoscopy image quality and testing completion rate.

Objective To study the state, feature and risk factors of bacterial infection in patients with liver cirrhosis, find out the influence of infection on prognosis, and provide scientific basis for its prevention and treatment. Methods Three hundred and twenty-three patients with liver cirrhosis were analyzed. The number of the patients with infection, the location of infection, clinical feature as well as the kind of pathogenic bacteria were analyzed. Unconditional Logistic regression analysis was used to assess the risk factors of bacterial infection. Results The overall infection rate was 39.94% (129/323),of which community acquired infection rate and nosocomial infection rate were 22.60% (73/323) and 17.34%(56/323) respectively. The most common location of infection in turn were respiratory tract,gastrointestinal tract, urinary tract,biliary tract and abdominal cavity. The main pathogenic bacteria was Gram-negative bacillus, most of which had drug resistance for cefquinome and quinolones. The risk factors related with bacterial infection included liver cancer, Child-Pugh class B and C grade of liver function, gastrointestinal tract bleeding, diabetes mellitus,invasive operations and the length of staying in hospital. Conclusions The incidence rate of infection in patients with liver cirrhosis is higher. Multiple factors are likely to affect the incidence rate of infection in patients with liver cirrhosis.

Objective To discuss the effects of health management model on mental health of undergraduates. Methods A total of 2244 freshmen from a college were randomly assigned to the study group (n =824) and the control group (n = 1420) in 2009. Chinese College Students Mental Health Scale (CCSMHS) was used to investigate the changes of the participants in the study group after receiving the health management and analyze psychological differences between 2 groups. Results In CCSMHS,all P was found to be less than 0. 05, except for anxiety ( t = 1.90, P = 0. 058 ), reliance ( t = 1.27, P = 0. 206), and impulse (t = -0. 60, P = 0. 551 ). In 8 dimensionalities with significant differences, scores were decreased after health management when compared with baselines. Instead of body ( t = - 1.38, P = 0. 168 ), all the other scores showed statistically significant differences between the 2 groups. Conclusion Mental health of those who received health management was better than those who didn't. However, anxiety, reliant, and impulse did not improve as a result of shorter intervention time, and the challenge facing psychology intervenion.

Objective To investigate a safe, highly efficient and rapid skin expansion method. Methods Syringe pump and pump control of automatic (PCA) replacemented normal affusion were used with shorter and vertical skin professional jargon for continuous and constant pressure skin expansion. Twenty cases (23 expanders) were carried out in this way. Results The maximum area of defect was 16 cm?20 cm, and the minimum area of defect was 3 cm?3 cm. The expanders were used for 18 days and the volume of expanders were 40-900 ml . It was more rapidly than normal affusion. There were no more complications except a case of expander leakage, and others expressed their satifactions Conclusion This modification of the skin expansion is a safe, comfortable, convenient to carry with. It is worth recommendation.

Objective To explore the treatment effect and application value of ultrasonic guided mammotome minimally invasive whirling surgery and open surgery for benign breast tumor.Methods 264 patients with benign breast diseases were randomly divided into observation group and control group,132 cases in each group.The control group took open surgery,the observation group used mammotome minimally invasive surgery,rotary cutting system.Recorded clinical surgery treatment of the two groups.Results The operating time,intraoperative blood loss,operation scar size of the observation group were (18.27 ± 3.05) min,(10.86 ± 1.69) mL,(2.76 ± 0.85) mm respectively,those of the control group were (53.48 ± 6.17) min,(97.54 ± 14.28) mL,(27.63 ± 4.31) mm respectively,the differences between the two groups were statistically significant (t =58.7753,69.2560,65.0429,all P ＜ 0.05).In the observation group,breast deformation in 0 case,postoperative occurrence skin pigmentation in 1 case,itchy skin in 2 cases,with lateral swelling in 1 case,the patients' satisfaction score was (93.42 ± 3.89) points.In the control group,breast deformation in 5 cases,postoperative occurrence skin pigmentation in 8 cases,skin itching in 9 cases,lateral swelling in 7 cases,the patients' satisfaction score was (88.16 ± 1.45) points,the differences between the two groups were statistically significant(x2 =5.096,5.636,4.648,4.604,t =14.557,all P ＜0.05).Conclusion Using ultrasonic guided mammotome minimally invasive rotary surgical treatment for benign breast diseases can shorten the operation time,reduce intraoperative bleeding,reduce the incidence of postoperative complications,patients' satisfaction is higher,and it is worthy of popularization and application in clinic.

Objective To investigate the risk factors of dual anti-platelet treatment in upper gastrointestinal hemor-rhage after percutaneous coronary intervention (PCI). Methods Clinical data of 2004 PCI patients with dual anti-platelet treatment were collected,including gender,age,body mass index (BMI),history of drug therapy, history of digestive disease, history of smoking and drinking,history of hypertension,history of diabetes,history of cerebrovascular disease and history of combined treatment with a proton pump inhibitor (PPI). The different characteristics of gastrointestinal bleeding were com-pared. The risk factors of upper gastrointestinal bleeding were analyzed. Results The risk factors for PCI patients with up-per gastrointestinal bleeding were age>65 years of old, history of smoking, history of hypertension,abnormal platelet count, creatinine and hemoglobin. The combined treatment with a proton pump inhibitor was a protective factor associated with gas-trointestinal bleeding. Conclusion We should pay attention to the upper gastrointestinal bleeding induced by dual anti-platelet treatment, and take appropriate measures to reduce the incidence of gastrointestinal bleeding in PCI patients.

Objective To study the functions of GPⅠa/Ⅱa and GPⅣduring the course of platelet adhesion to collagen. Methods Reaction system which contains anti-GPⅠa/Ⅱa antibody ,anti-GPⅣantibody or no blocking antibody was analyzed by flow cytomety. PE labeled anti-CD42b antibody was used to select platelet and fluorescence intension of fluorescein isothiocyanate ( FITC) was detected during the course of platelet adhesion to FITC-labeled collagen. Results The antibody against GPⅠa/Ⅱa inhibited platelet adhesion to collagen, especially to activated platelet(P 0. 05 ). Conclusion GPⅠa/Ⅱa plays an important roles in platelet adhesion to collagen. Blocking GPⅠa/Ⅱa may decrease the adhesion. GPⅣmay be helpful for acceleration of platelet adhesion to collagen at early stage.

Objective To investigate the function of GPⅠa/Ⅱa in the platelet-collage adhesion and the platelet granules release induced by collagen. Methods With the flow cytometry, in either presence or absence of the anti-GPⅠa/Ⅱa antibody: (1) PE-labeled anti-CD42b antibody was used for selecting platelet and FITC fluorescence intension was detected during the course of platelet adhered to FITC-labeled collagen. (2) PerCP-labeled anti-CD61 antibody was used for selecting platelet and detecting CD62P with PE-labeled CD62P antibody during platelet granule release induced by collagen. Results Anti-GPⅠa/Ⅱa antibody inhibited the platelet-collagen adhesion, especially the activated platelet-collagen adhesion (P0.05). Conclusion GPⅠa/Ⅱa plays an important role in platelet-collagen adhesion. Blocking GPⅠa/Ⅱa can decrease the platelet-collagen adhesion, but has no effects on platelet granule release reaction.

OBJECTIVE To find out the prevalent distribution and multidrug resistance trend of meticillin-resistant Staphylococcus(MRS) and to prevent fulminant prevalence of MRS and opt for effective therapeutic means.METHODS The bacterium was(identified) by the way of API Staph and the TH-16S′s coding tube.The(antimicrobial) susceptibility testing was adoped by ATB-STAPH5 and MRS was examined by dilution and K-B.All statistical analyses were performed using SPLM 3.0 software.RESULTS The isolation rate of meticillin-resistant S.aureus(MRSA) and meticillin-resistant coagulase negative Staphylococcus(MRCNS) was 38.09%,20.00%and 87.65%,89.00%,(respectively) in 2 years.Along with the age of patients,the infection from MRS was(increasing).The isolation rate of MRSA was 28-26%,but that of MRCNS was more than 80% from S.epidermidis,S.haemolyticus,S.hominis,and S.saprophyticus subsp saprophyticus.All parts of our body can be(infected) by MRS.The more than 30% MRSA were multidrug resistant and the approximately 11.87-13.75% MRCNS were also multidrug(resistant).(CONCLUSIONS) The isolation rate of MRSA from national surveillance(network) is not(different) with that of MRCNS.