Objective To evaluate the advantages and disadvantages of cervical strap muscles longitudinal incision and linea alba cervicalis incision in thyroid surgery.Methods The clinical data of 91 patients with thyroid surgery wefe retrospectively analyzed.They were divided into two groups by random digits table,46 patients with cervical stsap muscles longitudinal incision as the observation group,45patients with linea alba cervicalis incision as the control group,the surgery effect of two groups was compared. Results The operative time,blood loss and postoperative complications between the two groups,the differences were not statistically significant(P>0.05).Compared with control group,the exposure evaluation scores in the upper pole[(3.88±0.32)points vs.(2.15±0.22)points],under pole[(3.68±0.46) points vs.(2.18±0.42) points]and lateral side[(3.55±0.47)points vs.(2.18±0.39)points]of thyroid in observation group were significantly better (P<0.01),but the exposure effect scores in thyroid gorge were signilicantly lower [(2.31±0.39) points vs.(3.48±0.52) points](P<0.01),SF-36 score was better [(77.1±7.3) points vs.(66.4±6.8)points](P<0.05).Conclusion The effects of cervical strap muscles longitudinal incision and linea alba cervicalis incision in thyroid surgery are satisfactory,but the exposure effect of two incision are different,thus it is required to choose the applications according to the conditions ofpatients.

Neonatal acute heart failure is a common critical illness,and also one of the material cause of perinatal death. It is difficult for early diagnosis due to the different characteristics and clinical manifestation between neonate and older children, which leads to the difficulty of diagnosis timely and affect the condition adversely. This article introduced the common etiology, characteristics of clinical manifestation, diagnosis and treatment of neonatal acute heart failure.

Objective To explore the treatment effect and application value of ultrasonic guided mammotome minimally invasive whirling surgery and open surgery for benign breast tumor.Methods 264 patients with benign breast diseases were randomly divided into observation group and control group,132 cases in each group.The control group took open surgery,the observation group used mammotome minimally invasive surgery,rotary cutting system.Recorded clinical surgery treatment of the two groups.Results The operating time,intraoperative blood loss,operation scar size of the observation group were (18.27 ± 3.05) min,(10.86 ± 1.69) mL,(2.76 ± 0.85) mm respectively,those of the control group were (53.48 ± 6.17) min,(97.54 ± 14.28) mL,(27.63 ± 4.31) mm respectively,the differences between the two groups were statistically significant (t =58.7753,69.2560,65.0429,all P ＜ 0.05).In the observation group,breast deformation in 0 case,postoperative occurrence skin pigmentation in 1 case,itchy skin in 2 cases,with lateral swelling in 1 case,the patients' satisfaction score was (93.42 ± 3.89) points.In the control group,breast deformation in 5 cases,postoperative occurrence skin pigmentation in 8 cases,skin itching in 9 cases,lateral swelling in 7 cases,the patients' satisfaction score was (88.16 ± 1.45) points,the differences between the two groups were statistically significant(x2 =5.096,5.636,4.648,4.604,t =14.557,all P ＜0.05).Conclusion Using ultrasonic guided mammotome minimally invasive rotary surgical treatment for benign breast diseases can shorten the operation time,reduce intraoperative bleeding,reduce the incidence of postoperative complications,patients' satisfaction is higher,and it is worthy of popularization and application in clinic.

The diagnostic value of glutamic acid decarboxylase antibody (GAD 65-Ab) was more valuable than islet cell antibody (ICA) in type 1 diabetes mellitus by receiver-operating characteristic (ROC) curves; likelihood ratios of different regions of GAD 65-Ab and ICA could reflect the probability of type 1 diabetes mellitus.

Objective To introduce a new major autoantigen and autoantibody in insulin-depenent diabetes mellitus.Meothds An English-lanuage literature was searched using MEDLINE (1992-1997.6). After independently reviewed by three observers, 19 of 30 originally indentified articles were selected that specifically indentified articles were selected that sepcifically addressed the stated purpose. Three observers independently asessed the biological properites and relationship with insulin-dependent diabetes meliitus of ICA512.Results ICA512 is a new member of the protein typrosine phosphatase family. Sixty-six percent of patients with insulin-dependent diagbetes mellitus have autoantibodies to ICA512. The positive prdictive value of ICA512 autoantibodies is 74.5%, in first-degree relatives of insulin-dependent diabetes mellitus. The combination of antibodies may increase the sensitivity to 100%. First-degree relatives with all three autoantiodies to insulin, glutamate acid decarboxylase, ICA512 had a risk of diabetes within 5 years estimated to be 100%.Conclusions Autoantibodies to ICA512 alone or combinedly with other autoantibodies are of great importance in the prediction and diagnosis of insulin-dependent diabetes mellitus.

Objective To study the distribution patterns of bacterial flora in sigmoid colon tissues and stools in normal population.Method Bacterial flora were identified and analyzed by using 16sDNA sequencing technology in fresh stool samples (n =13) and colon mucosa samples (n =10).Results The diversity and abundance of bacterial flora were significantly larger in the stool samples than in the sigmoid colon samples (P ＜ 0.001,P ＜ 0.001,P =0.042,P =0.006).The consititution of phylum flora between the two groups were same,including flrmicutes,bacteroides,proteobacteria,and actinomycetes.However,the proportions of firmicutes and bacteroides in stool samples were significantly higher than in the sigmoid colon samples,whereas the proportion of proteobacteria was significantly lower (P ＜ 0.001,P =0.025,P ＜ 0.001).At the genus level,faecalibacterium and bacteroides were the dominant flora in feces,whereas pseudomonas,lactococcus,acinetobacter,and flavobacterium were the most common flora in sigmoid colon mucosa.The amounts of bifidobacterium and lactobacillus were low in both two groups.Conclusion The distribution of bacterial flora remarkably differ in stools and sigmoid colon mucosa.

AIM: To study the effects of taurine at different doses on renal oxidative stress and inflammation induced by paraquat in rats.METHODS: Male SD rats (n=48) were randomly divided into 4 groups: negative control group, paraquat group, paraquat + low-dose taurine group, and paraquat + high-dose taurine group.The serum levels of creatinine and urea nitrogen were detected by a biochemical analyzer.The levels of malondialdehyde (MDA) and superoxide dismutase (SOD) were measured by colorimetry.The plasma concentrations of IL-6 and intercellular adhesion molecule (ICAM)-1 were detected by ELISA.Renal reactive oxygen species (ROS) was checked by fluorescence probe dihydroethidium (DHE).The protein levels of renal p-P38 MAPK, p-ERK1/2 and p-JNK were determined by Western blot.The mRNA expression of TNF-α, IL-6 and TGF-β1 was detected by real-time PCR.RESULTS: Serum creatinine and urea nitrogen increased after paraquat poisoning, and decreased after feeding with taurine in poisoned rats, with better result in high-dose taurine group.Taurine reduced the oxidative stress and inflammation in the renal tissue, and also reduced the protein levels of p-JNK, p-ERK1/2 and p-P38 in the kidney of paraquat-poisoned rats.CONCLUSION: Taurine attenuates renal injury induced by paraquat poisoning in rats.The mechanism may be related to reducing renal MAPK activity, oxidative stress and inflammatory response.

We analyszed 108 examination papers that were taken when the students of 8 groups had finished theexercitation. The attainment was 73.6?4.4 points. Among the 400 selective questions, the difficult questions whichwere concentrated only on a few diseases accounted for 35.3%. There was mush difference between the proportion of theselective questions and that of the demands of the teaching program in different system of diseases. There was few or noselective question in the important diseases of the teaching program. It is suggested that the proposition of difficultquestions must include the important diseases in the teaching program. The diseases that are not commonly encountereddiseases may be deleted from the teaching program, but the commonly encountered must be put in the teaching program.It is necessary to reinforce the ability of students to analyse and resolve problems[

Humans ; Lymphoma, Non-Hodgkin ; diagnosis ; Pleural Effusion

The effects of glipizide on SI、SG、KG、Iarea 0～20min、FBG、FINS with minimal model in non-insulin-dependent diabetes meIlitus were observed.The results showed SI、SG、KG、Iarea 0～20min were lower and FBG was higher in NIDDM than these in normal subjects before glipizide therapy.After two weeks of glipizide therapy,FBG was decreased and SI、SG、KG、Iarea 0～20min were increased.These data suggested that glipizide not only had the effect on stimulating islet ?-cell secretion,but also improving insulin sensitivity and glucose effectiveness.