d-Isochondordendrine isolated from Cyclea barbate Miers, 400-800 rng/kg ig inhibited the increased vascular permeability induced by ip 0.7% acetic acid in mice or histamine ic 0.05ug/0.05ml in rats. It markedly inhibited the swelling of mouse ear induced by xylene and the edema produced by injection of 1 % carrageenin , fresh egg white or 2.5% formaldehyde 0.lml beneath the plantar surface of hind paw in intact or adrenalectomized rats. It was effective in the cotton-pellet grahuloma inhibition test in rats after daily medica- tion for 6 d. d-lsochondrodendrine could significantly rnduce the leukocyte removal caused by 1 % carrageenin and the fever induced by sc 7% yeast suspension 3 ml/kg in rats