OBJECTIVE:To promote rational drug use in the clinic. METHODS: By reviewing the pertinent literature both at home and abroad, the causes of ADRs induced by Chinese medicine injections were analyzed. RESULTS: the reasons accountable for ADRs induced by Chinese medicine injections were as follows: the active ingredients in the Chinese herbal medicine; poor stability of preparation and the unreasonable preparation process; failing to follow indications in the treatment, drug incompatibility, improper dosage, improper administration and individual differences. CONCLUSION: It is necessary to strengthen monitoring in clinical application of Chinese medicine injections. Only through strictly following indications, probing into allergy history before drug use, making sure the quality of the injection is qualified, paying special attention to drug compatibility can the ADRs be greatly reduced or avoided.

0.05). Significant differences of post-operative VA, time of retinal detachment, and neurepithelial thickness were found (P0.05). Conclusions The time of retinal detachment and post-operative VA in patients with retinal detachment relate to the neurepithelial thickness detected by OCT. When the duration of retinal detachment becomes longer, the macular neurepithelium becomes thicker, the histomorphological changes increase, and the post-operative VA decreases.

OBJECTIVE:To facilitate the in-depth implementation of Prescription Administrative Policy("New Method" in short).METHODS:The change of the Prescription Administrative Policy and its problems were analyzed through comparison between the "New Method" and the trial edition.RESULTS & CONCLUSIONS:Improvements of Prescription Administrative Policy such as the introduction of prescription comment system,clarifying supervising subjects and strengthening requirement on prescription dispensing rights etc play a role in tightening comprehensive management on prescriptions and promoting rational drug use.However,the defects of Prescription Administrative Policy such as the absence of the regulations unsuitable for medical orders in retail pharmacy and endemic areas and the unidentified prescription forms need to be improved step by step in the practice.

Objective To manage calcaneal fractures with an U-shaped external fixator combined with close manipulative reduction. Methods From February 1997 to November 2002, 31 patients with 34 calcaneal fractures were treated with self-designed U-shaped external fixator combined with close manipulative reduction. All patients were males aging from 7 to 50 years with an average of 32 years. The external fixation device consisted of two partial rings, three modular connecting rods and several pins. According to Essex-Lopresti classification, there were 10 extra-articular fractures without involving the subtalar joint, and 24 intra-articular fractures involving the subtalar joint. Two upper pins were inserted in cross through the distal tibia, and one of two lower pins was inserted laterally through the anterior part of calcaneus, the other was posterior into the calcaneous tuberosity or larger fragment connecting with Achilles tendon. After the manipulative reduction, the frames were applied. Results 31 calcaneal fractures were found with satisfactory reductions after manipulation. The widths of the heels were restored in certain extent; the heights of foot arch and calcaneus were resumed to normal; the B hler angle increased from 15? to 40? (mean, 25?). The duration of hospitalization was on an average of 7 days. The duration of external fixation was averagely 8 weeks. All patients were followed up with a mean period of 8 months (range, 6 to 12 months). All of the fractures healed well. No nonunion, delayed healing of bone or other complications was found. All patients resumed to walk on foot after 2 to 4.5 months. According to Fernandez scoring system, results were graded as excellent and good in 31(91%). Conclusion Using U-shaped external fixator combined with close manipulative reduction is a satisfying technique to treat calcaneal fractures. By ankle joint spanned traction and fixation, this technique overcomes displacement of fragments caused by contracture of tendo calcaneus, maintains width of heel and biodynamic anatomy of foot, avoids complications of wound caused by open reduction and internal fixation.

The regional blood flow measurement (RBFM)of lenghtened limb with a peripheral circulation mesuremnt system was carried ou t in 20 rabbits after their tibia was lengthened in different lengthening rates.It was found that whenever a limb was lengthened with a rate over 1 mm/day,the RBFM of the lengthened limb decreased rapidly and returned to preoperative level 8 hours later.It is believed that the vascular and muscular tissues of a limb possess good adaptive capcity to the lengthening rate of 1 mm/day,When the lengthening rate exceeds 1 mm/day,it is liable to result in a significant re-duct of regional blood flow,and then atrophy and weakening of the muscles will occur.

Objective To study the operative methods and surgical technique of arthroscopical meniscal suture in treatment of meniscal tears under local anesthesia. Methods From February 1999 to November 2003, we cure 32 patients (22 males and 10 females) with this method. The patients' average age is 29. Results All of the patients accept the operation through arthroscopy under local anesthesia. The procedure last 50 minutes on an average. 92% of the patients gain good results, no severe complications. Conclusion This method has the advantages of less pain, time saving(save time), quick recovery and less complications.

Objective In order to explore pathogenesis about inflammation injury of the hematoma peripheral zone after cerebral hemorrhage. Methods 48 adult male wistar rats are randomly divided into intracerebral hemorrhage (ICH) groupand control group. After 3 h, 24 h,72 h and 7 d of ICH, intercellular adhesion molecule-1 (ICAM-1)was detected by immunohistochemical SABC staining in rats brain slice. Positive cells expression of the ICAM-1 were measured by color image analysis system。Brain edema were assayed by dry-wet weight method. Results The expression of ICAM-1 increased at 3 h ( P 0.05) compared to contral group. Conclusions The overexpression of ICAM-1 may play important role in the perihematoma edema formation and ischemic injury.

Objective To investigate the effect of salbutamol aerosol combined with magnesium sulfate on IL-2, IL-4, IL-5, IFN-γand T lymphocyte subsets in pediatric asthma patients.Methods 38 pediatric asthma patients were selected and randomly divided into control group and experimental group.Control group was treated by clinical routine method.Experimental group was treated by salbutamol aerosol combined with magnesium sulfate.The IL-2, IL-4, IL-5, IFN-γ, T lymphocyte subsets, blood pressure, heart rate, respiratory and clinical effects were observed and compared.ResuIts Compared with control group, the serum levels of IL-2 and IFN-γwere higher(P<0.05).The IL-5, IL-4 level were lower(P<0.05).The CD3 +, CD4 +, CD4 +/CD8 +level were higher(P<0.05).The serum CD8 +were lower(P<0.05).The total efficiency were higher(P<0.05).ConcIusion Salbutamol aerosol combined with magnesium sulfate can effectively regulate T lymphocyte subsets proportion and cytokine levels in asthmatic children, enhance immunity, and improve the clinical symptoms.

OBJECTIVE:To strengthen the inspection for qualification of new drugs when introduced in order to guarantee the quality of new drugs and the safety of drug use.METHODS:The problems existing in the inspection for qualification of new drugs were exemplified and classified.RESULTS&CONCLUSION:There existed the problems in the respect of validity,authenticity,effectiveness,and integrality.The good maintainance of the database of SFDA plays a important role in in-specting the new drugs when introduced,while on the other hand such issues as establishment and use of credibility file in medical agencies are worth discussing.