Human trials are necessary to medical development,but the experiments need to be reviewed under the condition of informed consent.The current ethical review of informed consent in China exist some limits.For example,the corresponding normative legal status is low,the tracing review of informed consent becomes a mere formality,and the ethical review mechanism is not perfect,and so on.We should strengthen the examination of the ethical examination of human trials,increase the tracking and examination of informed consent of human trials,and improve the supporting mechanism of ethical review,and thus to safeguard the life and health rights and interests and personality dignity.

OBJECTIVETo observe the life quality improvement of spastic hemiplegia of stroke treated with fire-needle.

METHODSSixty patients were randomly divided into a fire-needle group and a rehabilitation group, 30 cases in each one. In the two groups, the conventional treatment of neurology and rehabilitation strengthening limbs function were applied. In the fire-needle group, fire-needle was used at Jianyu (LI 15), Binao (LI 14), Quchi (LI 11), Yanglingquan (GB 34), Xuehai (SP 10) and Sanyinjiao (SP 6), etc. , once two days and continuously for 30 days (15 times). In the rehabilitation group, conventional rehabilitation exercises were given five times a week for 4 weeks (20 times). Before treatment, at the end of treating program and one month later after treatment, spasticity of upper and lower limbs was assessed by Ashworth scale and clinic spasticity index (CSI); limbs function was evaluated by Fugl-Meyer (FM) scale; life quality was estimated by patient-reported outcome (PRO). Clinical effects were compared between the two groups.

RESULTS(1) At the end of treating and one month later after treatment, the Ashworth scales were better than those before treatment in the two groups (P < 0.05, P < 0.01), and the scales of the fire-needle group were superior to those at the same time of the rehabilitation group (both P < 0.05). (2) At the end of treating and one month later after treatment, the CSIs were better than those be fore treatment in the fire-needle group (both P < 0.01), but not changed apparently in the rehabilitation group (both P > 0.05). And the indices of the fire-needle group were superior to those at the same time of the rehabilitation group (P < 0.05, P < 0.01). (3) The FM scales of upper and lower limbs at the end of treating and one month later after treatment were better than those before treatment in the two groups (all P 0.01), except the lower limbs at the end of treating in the rehabilitation group (P > 0.05). The FM scales of the fire-needle group were superior to those at the same time of the rehabilitation group (P < 0.05, P < 0.01). (4) At the end of treating and one month later after treatment, the PRO scales were better than those before treatment in the two groups (all P < 0.01), and the scales of the fire-needle group were superior to those at the same time of the rehabilitation group (P < 0.05, P < 0.01).

CONCLUSIONFire-needle can effectively relieve spastic hemiplegia of stroke, and improve limbs motor function and life quality. It is better than rehabilitation.

Acupuncture Therapy ; instrumentation ; methods ; Adult ; Aged ; Female ; Hemiplegia ; Humans ; Lower Extremity ; physiopathology ; Male ; Middle Aged ; Muscle Spasticity ; etiology ; physiopathology ; therapy ; Needles ; Quality of Life ; Stroke ; complications ; therapy ; Treatment Outcome ; Upper Extremity ; physiopathology

Objeetive To investigate the relationship between 24-hour blood pressure rhythm and carotid scleratheroma in elderly patients with hypertension.Methods 193 elderly patients with hypertension were enrolled in the study and divided into study group (91 cases with carotid atherosclerosis) and control group (102 cases).All the patients were given 24h blood pressure rhythm examination.The characteristics of 24hour blood pressure rhythm was compared between the two groups.Results The 24h average systolic blood pressure(24h-SBP),24h average diastolic blood pressure (24h-DBP),24h average pulse pressure (24h-MBP) between the study group and the control group had no significant differences(P ＞ 0.05).The daytime average systolic blood pressure(d-SBP),diurnal mean diastolic blood pressure (d-DBP),diurnal average pulse pressure (d-MBP),nocturnal mean systolic blood pressure (n-SBP),nocturnal mean diastolic blood pressure(n-DBP),nocturnal mean pulse pressure(n-MBP) of the study group were significantly higher than those of the control group (t =16.92,24.68,6.16,12.87,11.59,6.35,all P ＜0.05).In study group,d-SBP,d-DBP,d-MBP were higher than n-SBP,n-DBP,n-MBP,the differences were statistically significant(F =73.61,P ＜ 0.01).The circadian blood pressure variability of the study group was more than 10％,the 24h ambulatory blood pressure curve graph of the study group was non-dipper curve.The circadian blood pressure variability of the control group was less than 5％,the 24h ambulatory blood pressure curve was dipper type curve.Conclusion The MBPS is strongly associated with carotid scleratheroma,and clinical treatment and study could derive from ABPM data analysis.

The relapse and refractoriness of multiple myeloma is still the most tough problems in clinical practise.With the increasing cognition of pathogenesis on multiple myeloma, lots of new drugs are constantly emerging with its clinical efficacy and side-effect are gradually acknowledged. There are a serial of new agents and therapies targeted relapsed and refractory multiple myeloma have spring up. This paper will summarize the advancement of treatment for relapsed and refractory multiple myeloma.

Objective To retrospectively analyze of blood culture positive for adult patients with serum calcium concentration ,to understand the relationship between bloodstream infections in patients and serum calcium .Methods From January 2013 to July 2015 ,serum calcium (Ca) ,phosphorus (P) ,alkaline phosphatase (ALP) in 78 cases with the blood culture positive adult patients and 103 healthy subjects were detected and analyzed .Results The value of CA in adult patients was(1 .89 ± 0 .18) mmol/L ,healthy subjects while of that was (2 .23 ± 0 .23)mmol/L in healthy subjects ,There was statistically significant (P<0 .01) in two groups ;The P of patients was (1 .23 ± 0 .24)mmol/L ,which in healthy subjects was (1 .25 ± 0 .28)mmol/L ,There was no statistical differ‐ence (P>0 .05);ALP of patients was (78 ± 42)U/L ,which was (76 ± 40)U/L in healthy subjects .There was no statistical differ‐ence (P>0 .05) ,the r of Ca and P ,Ca and ALP were 0 .023 ,0 .023 respectively (P>0 .05) in patients ,while there were 0 .125 and 0 .132 (P<0 .05) in healthy subjects .Conclusion Calcium in serum of adult patients with blood culture positive might be reduced .

Objective To observe the effect of different doses of atorvastatin in treating elderly acute coronary syndrome.Methods Totally 78 cases with acute coronary syndrome were randomly divided into two groups:low-dose atorvastatin group and high dose atorvastatin group,39 cases for each.The triacylglycerol (TG),total cholesterol(TC),low-density lipoprotein-cholestrol (LDL-C)and high-density lipoprotein-cholestrol (HDL-C) were compared between before and after the treatment.The adverse drug reactions were observed.Results Before treatment,the levels of TG,TC,LDL-C and HDL-C were not statistic significant between the two groups.After treatment of 1 month,3 months,6 months and 12 months,TC and LDL-C of the two groups were decreased than those before treatment,and TC and LDL-C of high-dose atorvastatin group were lower than those of low-dose atorvastatin group,but HDL-C level was not changed compared with before treatment.After treatment of 3 months,6 months and 12 months,TG levels of the two groups were decreased than those before treatment,and TG of high-dose atorvastatin group were reduced than those of low-dose atorvastatin group.The incidence rate of cardiovascular events of high-dose atorvastatin group was significantly lower than those of low-dose atorvastatin group.There was no difference in the incidence rate of adverse drug reactions between the two groups.Conclusions I(s worthy to apply high-dose atorvastatin in clinical treatment for acute coronary syndrome because of its ability to decrease the levels of TG,TC,LDL C,HDL-C and cardiovascular events.

The fine composition of volatile oils in a raw peppermint in July were analysed by combined means of programmed temperature capillary gas chromatography/mass spectrometry (GC/MS).20 compounds were separated and identified.The main constituents were (1α,2α,5β)-menthol (16.88%),(1α,2β,5β)-menthol (74.98%),cis-menthone(3.84%) and (2R-cis)-menthone (1.25%).In the whole July mint there were 4 groups of isomeric compound,their molecular formula were C10 H16 (5 components),C10 H18 O (2 components),C10 H20 O (2 components) and C15H24(8 components),respectively.

OBJECTIVE:To evaluate the effects of clinical pharmacist participating in clinical consultation,and to provider ref-erence for clinical pharmacists participating in clinical practice. METHODS:436 cases/times of clinical consultation in which clini-cal pharmacists participated in Zhengzhou Seventh People’s Hospital from 2012 to 2015 were analyzed statistically. RESULTS:2012-2015,the number of clinical consultation in the hospital showed rising tendency;23 departments applied the consultation, among which top 5 were endocrinology department,gynaecology department,neurosurgery department,neurology department and orthopedics department. The reasons for consultation mainly were the formulation of therapy plan (430 cases/times,accounting for 97.95%). The consultation suggestions were adjusting drug types(303 cases/times,69.17%). Consultation suggestions were adopt-ed completely in 405 cases/times(92.89%). There were 307 cases/times of effective outcome,with effective rate of 75.80%(307/405). CONCLUSIONS:Clinical pharmacists participated in clinical consultation is helpful to optimize therapy plan,play a positive play on the safety of drug use. Clinical pharmacists should further learn clinical medical and pharmaceutical knowledge and summa-rize the experience of clinical practice to improve the quality of consultation.

In this study,we have observed the effects of extract from mussel ( Mytilus edulis Linnaeus ) on experimental hyperlipidemia in rats.The results showed that the extract from mussel could reduce the levels of total cholesterol and triglyceride in blood serum of the experimental hyperlipidemic rats.

Objective To detect serum leucine aminopeptidase (LAP) level in the patients with hyperthyroidism for investiga‐ting the changes of LAP in the patients with thyroid dysfunction and its clinical significance .Methods 117 patients with hyperthy‐roidism were taken as the test group and 109 healthy people as the control group .The differences of various laboratory indexes were comparatively analyzed and the correlation between LAP with FT 3 ,FT4 and TSH was analyzed .117 patients with hyperthyroidism were divided into the liver damage group(52 cases) and non‐liver damage group(65 cases) and performed the LAP determination . Results The serum LAP ,FT3 ,FT4 and TSH levels in the hyperthyroidism whole group ,hyperthyroidism liver damage group and hyperthyroidism non‐liver damage group had statistically significant differences compared with those in the control group (P<0 .01) ,serum LAP was positively correlated with FT 3 and FT4 ,and negatively correlated with TSH ;LAP ,FT3 ,FT4 and TSH had no statistical differences between the hyperthyroidism live damage group and the hyperthyroidism non‐liver damage group (P>0 .05) .Conclusion The serum LAP content is closely related with the thyroid hormones and has certain clinical reference value for the diagnosis ,disease condition evaluation and medication .Lap can serve as an independent diagnostic indicator .