Objective To explore 3D constructive interference insteady state sequence value of related diseases in trigeminal neuralgia.Methods A retrospective analysis of 62 cases of trigeminal neuralgia as the main symptoms of patients with brain magnetic resonance imaging (MRI) routine scan and 3D constructive interference insteady state (3D-CISS) sequence images,of which 12 cases were enhanced scan,comparative analysis of MRI 3D-CISS sequence and conventional sequence of trigeminal nerve.The lesion showed the condition and was compared with the outcome of the operation.Trigeminal neuralgia-related lesions mainly included the trigeminal nerve brain pool around the vascular compression or transition,solid tumors and tumor-like lesions.Results Preoperative MRI 3D-CISS sequence was used to diagnose the vascular compression or metastasis of the trigeminal nerve pool segment in 46 cases.Forty-five patients were found to be responsible blood vessels.The 3D-CISS sequence showed 95.83％ coincidence with surgical exploration.The routine sequence could not show the trigeminal The brain around the brain was forced or pushed.3D-CISS sequence showed eight cases of solid tumors,routine scan showed six cases of solid tumors.Tumor-like lesions were shown in 6 cases of MRI3D-CISS sequences and routine plain scan sequences.The sensitivity of 3D-CISS sequence to trigeminal neuralgia-related disease was 96.77％,and the sensitivity of MRI routine scan to trigeminal neuralgia was only 19.35％.There was significant difference in the sensitivity of 3D-CISS sequence and conventional plain scan sequence to trigeminal neuralgia-related diseases (P ＜ 0.01).Conclusions MRI 3D-CISS sequence has a significant advantage in trigeminal neuralgia-related disease,and patients with trigeminal neuralgia should routinely use 3D-CISS sequences.