[Objective]To observe the effect of Bupiwei Shengyang Sanhuo Decoction in treating the atrophic glossitis ocurrring in intermediate or advanced stage tumor patients.[Methods]We chose 44 malignant tumor patients complicating atrophic glossitis,divided them into the control group,herbal group and western medicine group randomly.Finally it contrasted the effect among three groups.[Result]The healing rate(26.7%),total effective rate(66.7%)and the appetite improvement rate(60%)of the herbal group were better than the other two groups(P

Objective To study the efficacy of chemotherapy combined with immunotherapy in treatment of middle and advanced stage non-small cell lung cancer and improvement of patients'life quality.Methods 140 patients with middle and advanced stage non-small cell lung cancer treated from Mar .2012 to Mar.2014 were in-cluded and they were randomly divided into two groups:the observation group(70 cases)and the control group(70 cases).The observation group took chemotherapy combined with immunotherapy , while the control group took chemotherapy treatment alone .Patients'life quality , treatment effects and changes in immune indexes were co-mared between the two groups .Results The improvement rate of life quality of the observation group (90.0%) was significantly higher than that of the control group (58.6%), and the difference had satistical significance (P<0.05).The response rate of the observation group (88.6%) was significantly higher than that of the control group(70.0%), and the difference had statistical significance (P<0.05).The increasement rate of CD3 +, CD4 +, CD8 +cells, as well as CD4 +/CD8 +cells was significantly higher in the observation group than in the control group, and the difference had statistical significance (P<0.05).Conclusion Chemotherapy combined with immunotherapy in teatment of patients with middle and advanced non-small cell lung cancer has obvious effect, high safety, and high clinical value .

Objective To evaluate the effect of minimally invasive therapy for treating intraventricular hemorrhage.Methods The minimally invasive therapy with unilateral or bilateral drainage were received according to quantity and shape of intraventricular hemorrhage.Results It was operated 22 cases with unilateral drainage and 28 cases with bilateral drainage in the 50 cases intraventricular hemorrhage.Death was 3 cases and mortality rate was 6% in the minimally invasive therapy.ADL1 15 cases(30%),ADL2 18 CRSeS(36%),ADL3 8 cases(16%),ADLA4 cases(8%),ADL5 2 cases(4%)in leave hospital.Conclusion Minimal invasive therapy of intraventrieular hemorrhage has great superiority,such as it can operate simple,trauma mild,decrease complications and enhance curative effect.It can generalize in the basic hospital.

Objective - To analyze the relation between classes and prognosis of the brain.stem hemorrhage.Methods 37 patients with spontaneous brainstem hemorrhage were divided into three groups according to con-sciousness and breathing function: Ⅰ group 13 cases with consciousness; Ⅱ group 11 cases without consciousness; Ⅲgroup 13 cases without consciousness and respiration, according to the classes, using different ways and means. Re-suits Ⅰ group 13 cases survival in 13 cases; Ⅱ group 10 cases survival and 1 case death in 11 cases; Ⅲ group 1 case survival and 12 cases death in 13 eases. Conclusion The classes of the brain.stem hemorrhage is propitious to select therapeutic measure and prognostic estimate. The intensive care and the surgery can reduce mortality rate.

Objective To explore the experiment of Mg2+on effects of cell apoptosis of rabbit secondary brain injury. Methods Fifty New Zealand white rabbits, irrespective of genders were selected, they were randomly divided into ex-perimental group, control group and operation control group, 20 rats in each group of the experimental group and the control group, 10 rabbits were in the sham operation group; animal were used magnesium sulfate after brain injury in the early vein,through the pathology examination of brain tissue around contusion foci, X-ray examination of electron microscopy and cell apoptosis detection, the effect of magnesium ion on the cell apoptosis in secondary brain damage was analyzed. Results The control group after 6 h of brain injury, pathology showed focus of the lesions appeared haem-orrhage, the organization gap widened, peripheral edema, 48 h after brain injury was most significant, the lesions ap-peared cell membrane structure complete, the nucleus pycnosised nerve cells,that was to say, neural cell apoptosis, apoptotic cells were relatively dense; Neural cell degeneration and necrosis of experimental group were less , brain edema was lighter, there were no significant differences on both sides of the lesions; the expression of TUNEL positive cells in normal brain tissue was less, 6-hour-injury specimens appeared TUNEL powder in a small number of positive cells, the number of TUNEL positive cells of specimens of two groups increased with the prolongation of injury time, the peak period was 24 hours, TUNEL positive cells at different stages in the experimental group were significantly lower than those of the control group at the same time segment, the difference had statistical significance (P<0.05). Conclusion Magnesium ions can reduce the number of nerve cell apoptosis of rabbit secondary brain injury, play a pro-tective role in injury of cerebral nerve cells.

Objective:To evaluate the early efficacy and safety of transnasal endoscopic decompression in the annulus of zinn (AZ) region for refractory dysthyroid optic neuropathy (DON) and to preliminarily analyze the correlated factors of postoperative visual function outcome.Methods:From July 2021 to January 2023, 35 patients (56 eyes) with DON who received AZ area decompression in Peking University Third Hospital were included retrospectively, including 9 males (13 eyes) and 26 females (43 eyes), aging (52.2±12.0) years. Among them, 35 eyes underwent two-wall (medial and inferior) orbital decompression using an endonasal endoscopic approach, while 21 eyes received three-wall (medial, lateral, and inferior) orbital decompression through a combined approach. Key parameters such as best corrected visual acuity (BCVA), visual field (MD value), eyeball prominence, intraocular pressure, and complications were recorded. Postoperative data were collected one month after surgery. The statistical analysis was performed using paired t-test and Spearman correlation analysis. Results:Significant outcomes were observed post surgery in BCVA, visual field, intraocular pressure and proptosis ( t value was 8.37, 6.17, 4.50, and 9.20, respectively, all P<0.001). The reduction in proptosis was statistically significant between the 2-wall and 3-wall orbital decompression groups ( t=-2.82, P=0.007). Changes in BCVA, visual field, and intraocular pressure before and after surgery was greater in the 3-wall orbital decompression group compared to 2-wall orbital decompression group, although the difference was not statistically significant (all P>0.05). Change in postoperative visual acuity and visual field was significantly positively correlated with preoperative visual acuity and preoperative visual field (all P<0.001). Similarly, change in intraocular pressure and proptosis was positively correlated with preoperative intraocular pressure and preoperative protrusion (all P<0.001). Preoperative diplopia was reported in seven patients (20.0%), and two new cases (5.7%) were noted post-operation, which resolved within 3 months after surgery. Conclusions:Endoscopic endonasal decompression of the AZ area is a safe and effective surgical treatment for DON, with notable improvements in BCVA. Furthermore, three-orbital wall decompression seems to yield better outcomes in terms of eye retraction.