[Objective]To study etiology and pathogenesis,treatment and prescription of"head sweating",based on the theory of"opening,closing and pivoting six meridians"from Huangdi Neijing.[Methods]Based on the provisions of"head sweating"in the classic works,the dynamic correlation between the imbalance of"opening,closing and pivoting six meridians"and"head sweating"was explored,and the pathogenesis classification and corresponding treatment were summarized.[Results]The pathogenesis of"head sweating"primarily involves Yangming heat obstruction and Shaoyang pivot stagnation.The treatment principle focuses on purging heat and promoting descent,and unblocking the pivot mechanism.If coexisting with Taiyin dampness retention,Taiyang exterior constraint or hyperactivity,the treatment is supplemented by transforming and transporting dampness,unblocking Yang and venting the exterior,or securing the exterior to arrest sweating.When the exterior constraint is pronounced,the primary focus should be on resolving the exterior constraint.When it is not pronounced,treatment should focus directly on the main channels.In severe cases,it may manifest as Jueyin Yin-Yang conflict or Shaoyin pivot mechanism disruption.The treatment principle focuses primarily on reconnecting Yin and Yang,or consolidating Yang while preserving Yin.Additionally,when the pattern pertains to Jueyin but the symptoms are not severe,treatment can be approached from the Shaoyang perspective.For refractory cases of"head sweating"with prolonged duration,adjunct therapy employing resolve phlegm and dissipate stasis methods can significantly enhance therapeutic efficacy.[Conclusion]The treatment of"head sweating"takes"regulating the Qi dynamic and restoring the balance between opening and closing functions"as its guiding principle.The Taiyang and Taiyin systems emphasize the opening function.The Yangming and Jueyin systems value the closing function.The Shaoyang and Shaoyin systems excel in their subtle pivoting function.When the three Yin and three Yang meridians each fulfill their respective duties,the head sweating will be spontaneously resolved.The theory of"opening,closing and pivoting six meridians"provides a dynamic and holistic conceptual framework for the precise pattern differentiation and treatment of"head sweating",while offering novel diagnostic and therapeutic strategies for clinical management of this condition.

Objective To investigate the impact of continuous nebulization therapy after lung transplantation on pulmonary function and related complications in lung transplant recipients. Methods A retrospective analysis was conducted on the general data of 71 recipients who underwent allogeneic lung transplantation at the Department of Thoracic Surgery, the First Affiliated Hospital of Zhengzhou University, from June 2013 to December 2024. Recipients were divided into observation group (those who continued nebulization therapy for more than 3 months after discharge) and control group (those who discontinued nebulization therapy on their own). The main observation indicators were pulmonary function indicators at 6 months after surgery, including forced expiratory volume in the first second as a percentage of predicted value (FEV₁% pred), forced vital capacity as a percentage of predicted value (FVC% pred), ratio of forced expiratory volume in the first second to forced vital capacity as a percentage of predicted value (FEV₁/FVC% pred), forced expiratory flow at 25%, 50% and 75% of forced vital capacity as a percentage of predicted value, and the percentage of predicted value of corrected carbon monoxide diffusion capacity measured by single-breath method, as well as the ratio of corrected carbon monoxide diffusion capacity to alveolar volume as a percentage of predicted value. Additionally, the annual incidence of postoperative pulmonary infections, survival rate and the rate of no severe airway complications were analyzed. Results At 6 months after lung transplantation, the FEV₁% pred and FVC% pred of the observation group were better than those of the control group [FEV₁% pred was 76% (60%, 91%) vs. 67% (62%, 78%), FVC% pred was (75 ± 13)% vs. (69 ± 11)%, both P<0.05]. The observation group had a lower annual incidence of pulmonary infections compared to the control group (P = 0.023), with a risk of 0.485 times that of the control group. There were no statistically significant differences between the two groups in median survival time and the rate of no severe airway complications (both P>0.05). Conclusions Continuous nebulization therapy after lung transplantation may effectively improve pulmonary function, reduce the annual incidence of pulmonary infections, and play a positive role in the long-term maintenance of pulmonary function.

Objective To addresses the challenges arising from the rapid expansion of pharmaceutical clinical trials and the growing demands for quality management,this paper investigates the application of low-code technology in project management.Its goals are to enhance the operational efficiency and execution capabilities of clinical trial institutions,ensure trial quality and safety,and accelerate the translation of pharmaceutical scientific achievements.Methods A brainstorming session was conducted to analyze the technical and functional requirements for managing pharmaceutical clinical trial projects.Utilizing the ＂template design＂ and ＂decision analysis＂ functionalities of low-code technology,the study adopted a modular and visually driven data management approach to develop a system compliant with Good Clinical Practice(GCP)standards.This system integrates key functionalities,including project progress management,funding management,drug inventory management,and quality control.Its effectiveness was evaluated through real-world operation and performance validation.Results The system had demonstrated stable operation with substantial improvements in practical application.Compared with conventional management approaches,it significantly enhanced project management efficiency:the time required for project schedule management was reduced by 80%,the efficiency of financial processing increased by 95%,drug inventory management efficiency improved by 75%,and the time spent on quality control was shortened by 60%.Conclusion The pharmaceutical clinical trial project management system developed using low-code technology offers substantial advantages and promising application potential.It represents a critical practice in applying digital and intelligent tools to advance pharmaceutical productivity in the medical and healthcare sectors.

[Objective]To study etiology and pathogenesis,treatment and prescription of"head sweating",based on the theory of"opening,closing and pivoting six meridians"from Huangdi Neijing.[Methods]Based on the provisions of"head sweating"in the classic works,the dynamic correlation between the imbalance of"opening,closing and pivoting six meridians"and"head sweating"was explored,and the pathogenesis classification and corresponding treatment were summarized.[Results]The pathogenesis of"head sweating"primarily involves Yangming heat obstruction and Shaoyang pivot stagnation.The treatment principle focuses on purging heat and promoting descent,and unblocking the pivot mechanism.If coexisting with Taiyin dampness retention,Taiyang exterior constraint or hyperactivity,the treatment is supplemented by transforming and transporting dampness,unblocking Yang and venting the exterior,or securing the exterior to arrest sweating.When the exterior constraint is pronounced,the primary focus should be on resolving the exterior constraint.When it is not pronounced,treatment should focus directly on the main channels.In severe cases,it may manifest as Jueyin Yin-Yang conflict or Shaoyin pivot mechanism disruption.The treatment principle focuses primarily on reconnecting Yin and Yang,or consolidating Yang while preserving Yin.Additionally,when the pattern pertains to Jueyin but the symptoms are not severe,treatment can be approached from the Shaoyang perspective.For refractory cases of"head sweating"with prolonged duration,adjunct therapy employing resolve phlegm and dissipate stasis methods can significantly enhance therapeutic efficacy.[Conclusion]The treatment of"head sweating"takes"regulating the Qi dynamic and restoring the balance between opening and closing functions"as its guiding principle.The Taiyang and Taiyin systems emphasize the opening function.The Yangming and Jueyin systems value the closing function.The Shaoyang and Shaoyin systems excel in their subtle pivoting function.When the three Yin and three Yang meridians each fulfill their respective duties,the head sweating will be spontaneously resolved.The theory of"opening,closing and pivoting six meridians"provides a dynamic and holistic conceptual framework for the precise pattern differentiation and treatment of"head sweating",while offering novel diagnostic and therapeutic strategies for clinical management of this condition.

Objective To addresses the challenges arising from the rapid expansion of pharmaceutical clinical trials and the growing demands for quality management,this paper investigates the application of low-code technology in project management.Its goals are to enhance the operational efficiency and execution capabilities of clinical trial institutions,ensure trial quality and safety,and accelerate the translation of pharmaceutical scientific achievements.Methods A brainstorming session was conducted to analyze the technical and functional requirements for managing pharmaceutical clinical trial projects.Utilizing the ＂template design＂ and ＂decision analysis＂ functionalities of low-code technology,the study adopted a modular and visually driven data management approach to develop a system compliant with Good Clinical Practice(GCP)standards.This system integrates key functionalities,including project progress management,funding management,drug inventory management,and quality control.Its effectiveness was evaluated through real-world operation and performance validation.Results The system had demonstrated stable operation with substantial improvements in practical application.Compared with conventional management approaches,it significantly enhanced project management efficiency:the time required for project schedule management was reduced by 80%,the efficiency of financial processing increased by 95%,drug inventory management efficiency improved by 75%,and the time spent on quality control was shortened by 60%.Conclusion The pharmaceutical clinical trial project management system developed using low-code technology offers substantial advantages and promising application potential.It represents a critical practice in applying digital and intelligent tools to advance pharmaceutical productivity in the medical and healthcare sectors.

Objective:To study the application of 3D printing technology in multi-center fenestrated/branched endovascular repair (F/B-EVAR) for endovascular repair of abdominal aortic diseases.Methods:From Feb 2018 to Mar 2023, The clinical and followup data of 316 cases of abdominal aortic lesions undergoing repair with F/B-EVAR at 69 medical centers nationwide using 3D printing technology to guide physician-modified stent graft were retrospectively analyzed.Results:The mean follow-up time of the patients was 23 months (2-60 months), and 24 cases were lost to follow up, the follow-up rate was 92.4% (292/316), the mean postoperative hospitalization time was (8.2±4.9) days. A total of 944 main abdominal branch arteries were reconstructed. Intraoperative reconstruction of 11 branches failed, with a success rate of 98.8% (933/944). Within 30 days after surgery, 8 patients died (2.5%), and 6 patients died during follow-up, a total of 14 patients died (4.4%). There were 11 cases (3.5%) of spinal cord ischemia and no patient suffered from permanent paraplegia. There were 19 patients (6.0%) with postoperative renal function injury. Internal leakage was found in 26 patients, and the rate of internal leakage was 8.2%.Conclusion:3D printing technology can accurately locate the location of branch arteries, simplifing the surgical process, shortening the learning curve , and improving clinical efficacy.

Objective:To review the risk factors for early and medium-term complications of fenestration-branch endovascular thoracic aortic repair (F/B-TEVAR) in patients with complex aortic arch disease.Methods:The clinical and follow-up data of 202 patients undergoing F/B-TEVAR treatment from Feb 2019 to Sep 2023 in these centers were retrospectively analyzed .Results:There were 46 cases suffering from postoperative complications (22.8%). The risk factors with statistical significance included aortic atherosclerotic plaque [ OR=2.843; 95% CI (1.4-5.6); P<0.01], aortic intramural thrombosis [ OR=2.358; 95% CI (1.2-4.6), P=0.011], the aortic dilatation [ OR=4.219; 95% CI (1.6-11.3), P<0.01], the history of stroke [ OR=2.088; 95% CI (1.1-4.1), P=0.032], smoking history [ OR=2.680; 95% CI: (1.3-5.5); P<0.01], duration of surgery [ OR=1.9; 95% CI: (1.2-2.9); P=0.042].While the application of 3D printing assistive technology [ OR=0.392; 95% CI: (0.2-0.9); P=0.048] was in a negative correlation with postoperative complication. Conclusions:The independent risk factors for complications after F/B-TVAR included aortic atherosclerotic plaque, aortic intramural thrombosis, the aortic dilatation, the history of stroke, smoking history,duration of surgery.The application of 3D printing technology can effectively reduce the complication rate.

To analyze the biological characteristics of Pasteurella multocida in bovine respiratory tract and its prevalence in large-scale cattle farms,bacterial isolation,culture,and morphological observation were conducted on the lungs and liver samples of dead cows suffering from respiratory diseases in Hohhot,Inner Mongolia.The isolated strains were studied through biochemical testing,16S rRNA gene sequencing,specific primer PCR identification,capsule serotyping,pathogenicity testing,virulence gene testing,drug sensitivity testing,and drug resistance gene detection methods.The results showed that six strains of Pasteurella multocida serotype A were isolated and identi-fied from the lungs of diseased and dead cows.After sequencing the 16S rRNA sequence of the bac-teria,it was found that the six strains of Pasteurella multocida had the closest genetic relationship with the Chongqing isolate CQ2(CP033599.1).The results of mouse pathogenicity test and viru-lence gene detection showed that all isolates were pathogenic and carried at least 16 or more related virulence genes such as exbB,nanB,sodC,oma 87,etc.,but no hsf1 and toxA were detected.The results of drug sensitivity tests and resistance gene detection showed that the isolated strains were sensitive to different degrees of antibiotics such as ciprofloxacin,ofloxacin,and cefotaxime.They were resistant to streptomycin,clindamycin,and lincomycin,and resistance genes of str A,strB,and tet(H)were detected.The results indicate that there is a certain correlation between the pathoge-nicity and virulence genes,drug resistance phenotype,and drug resistance genes of Pasteurellamultocida type A in cattle.It is recommended to use quinolones(such as ciprofloxacin)and cepha-losporins(such as cefotaxime)antibacterial drugs in clinical practice,which can provide scientific basis and prevention and control plans for the prevention and treatment of respiratory diseases caused by Pasteurella multocida in cattle farms,and lay a foundation for the epidemiological mo-nitoring of bovine respiratory multocida pasteurellosis.

Objective:To explore the current status of surgery for portal hypertension to grasp current status and future development of surgery in China.Methods:This study is jointly sponsored by China Hepatobiliary & Pancreatic Specialist Alliance & Portal Hypertension Alliance in China (CHESS).Comprehensive surveying is conducted for basic domestic situations of surgery for portal hypertension, including case load, surgical approaches, management of postoperative complications, primary effects, existing confusion and obstacles, liver transplantation(LT), laparoscopic procedures and transjugular intrahepatic portosystemic shunt(TIPS), etc.Results:A total of 8 512 cases of portal hypertension surgery are performed at 378 hospitals nationwide in 2021.Splenectomy plus devascularization predominated(53.0%)and laparoscopy accounted for 76.1%.Primary goal is preventing rebleeding(67.0%) and 72.8% of hospitals used preventive anticoagulants after conventional surgery.And 80.7% of teams believe that the formation of postoperative portal vein thrombosis is a surgical dilemma and 65.3% of hospitals practiced both laparoscopy and TIPS.The major reasons for patients with portal hypertension not receiving LT are due to a lack of qualifications for LT(69.3%)and economic factors(69.0%).Conclusions:Surgery is an integral part of management of portal hypertension in China.However, it is imperative to further standardize the grasp of surgical indications, the handling of surgical operation and the management of postoperative complications.Moreover, prospective, multi-center randomized controlled clinical studies should be performed.

Objective:To explore the regulation of miR-454-3p on the activity of lung cancer cells and the expression of CBX7 protein.Methods:Normal lung epithelial cells 293T cells and human lung cancer cell line A549 cells were cultured in vitro. Lung cancer cells (A549 cells) were divided into three groups: blank group, miR-NC group and miR-454-3p group. Cell counting kit-8 (CCK-8) method was used to detect the proliferation of the three groups; Transwell was used to detect the invasion number of the three groups; flow cytometry was used to detect the apoptosis rate; Western blot was used to detect the protein expression of CBX7 in lung cancer cells. Results:Compared with normal lung epithelial 293T cells, the expression of miR-454-3p mRNA in lung cancer A549 cells was significantly reduced, with significant difference ( P<0.05). There was no significant difference in the expression of CBX7 protein between the blank group and the miR-NC group ( P>0.05); The protein expression of CBX7 in miR-454-3p group was significantly higher than that in blank group and miR-NC group (all P<0.05). The results of CCK-8 showed that the A value of miR-454-3p group was significantly lower than that of blank group and miR-NC group (all P<0.05); there was no significant difference in the A value of lung cancer cells between blank group and miR-NC group ( P>0.05). The results of Transwell chamber experiment showed that the number of invasion cells in miR-454-3p group was significantly reduced compared with blank group and miR-NC group, and the invasive ability of lung cancer cells decreased significantly (all P<0.05); there was no significant change in the invasive ability of lung cancer cells between the blank group and miR-NC group ( P>0.05). The results of flow cytometry showed that there was no significant difference in the apoptosis rate between the blank group and miR-NC group ( P>0.05); compared with the blank group and miR-NC group, the apoptosis rate of lung cancer cells in miR-454-3p group increased significantly (all P<0.05). Conclusions:miR-454-3p is under-expressed in lung cancer cells. Overexpression of miR-454-3p can effectively regulate the biological activity of lung cancer cells, inhibit the proliferation and invasion of lung cancer cells, and promote cell apoptosis. Its mechanism may be related to the promotion of CBX7 protein expression by miR-454-3p.