1.Effects of vagus nerve stimulation on tumor necrosis factor-α, interleukin-1β and interleukin-10 levels in serum and brain tissues after blast brain injury in rabbits
Long ZHOU ; Jinhuang LIN ; Yigang YU ; Yuan GUO ; Junming LIN ; Zhicong DONG
Chinese Journal of Neuromedicine 2014;13(5):442-445
Objective To study the effects of vagus nerve stimulation (VNS) on brain tissue tumor necrosis factor-α (TNF-o),interleukin-1β (IL-1β) and IL-10 levels in serum and brain tissues after blast brain injury in rabbits.Methods Twenty New Zealand white male rabbits were randomly divided into sham-operated group (n=6),traumatic brain injury (TBI) group (n=10),TBI+VNS group (n=8).Rabbit brain blast injury models of TBI group and TBI+VNS group were established; and the right cervical vagus nerves of the rabbits in TBI+VNS group were stimulated (10 V,5 HZ,5 ms,20 min).The TNF-α,IL-1β and IL-10 changes in the serum (6 h after injury) and brain tissues (24 h after injury) and the water content in the injured brain tissues were observed and recorded.Results The TNF-α and IL-1β levels in the serum and brain tissues,the water content in the brain tissues of the TBI group were significantly higher than those in the sham-operated group and TBI+VNS group (P<0.05); the IL-10 level in the TBI+VNS group was significantly higher than that in the sham-operated group and TBI group (P<0.05).Conclusion VNS can reduce the brain edema degree by increasing the IL-10 level and decreasing the TNF-α and IL-1 β levels,which plays a key role in brain protection effect after brain blast injury in rabbits.
2.Epidemiological characteristics of hepatitis B in Guangzhou, 2006-2018i
Wenhui HU ; Qin ZHOU ; Yuan LIU ; Zhiqiang DONG ; Dedong WANG ; Jianrong HOU ; Yan KANG ; Wei LIU ; Xiangxiang LIU ; Zhicong YANG
Journal of Public Health and Preventive Medicine 2020;31(6):60-63
Objective To analyze the epidemiological characteristics of hepatitis B in Guangzhou from 2006 to 2018. Methods The data were retrieved from the National Infectious Disease Surveillance Information Report Management System. Descriptive methods were used to analyze and summarize the results. Chi-square test was used for statistical analysis of classification data, and Joinpoint software was used to analyze the annual change percentage and trend. Results A total of 292 674 cases of hepatitis B were reported in Guangzhou from 2006 to 2018, and the annual average reported incidence was 182.2 per 100,000. Chronic hepatitis B was the main type, accounting for 89.9%. The incidence rate of males (241.6 / 105) was higher than that of females (117.9 / 105), with a ratio of 2.0:1. During the period from 2006-2018, the reported incidence of hepatitis B in Guangzhou first increased, reached the highest in 2008, and then decreased year by year. There was no significant difference in the number of HBV cases among different months. The average onset age of hepatitis B reported in Guangzhou was 39.3 years old, and the average onset age increased year by year from 2006 to 2018. Conclusion The incidence rate of hepatitis B in Guangzhou has decreased since 2008, but it was still higher than the national average incidence rate. The hepatitis B infection in Guangzhou remains a big issue. It is suggested to further strengthen the prevention and control of hepatitis B in adults by maintaining a national immunization program for children, thereby reducing the epidemiological level of hepatitis B in Guangzhou.
3.Epidemiological characteristics of three local epidemics of COVID-19 in Guangzhou.
WenHeng ZHAO ; Yu MA ; Hui WANG ; Ke LI ; Hang DONG ; WenHui LIU ; YuanYuan LIU ; ShuQin JIANG ; Lei LUO ; ZhiCong YANG
Chinese Journal of Epidemiology 2021;42(12):2088-2095
Adult
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COVID-19
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China/epidemiology*
;
Epidemics
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Female
;
Humans
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Male
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SARS-CoV-2
4. Spatial distribution of cancer-related burden in Guangzhou from 2010 to 2013
Ao LUO ; Ke LI ; Yan LI ; Zhicong YANG ; Hang DONG ; Qiongying YANG ; Yu LIAO ; Xiao LIN ; Guozhen LIN ; Yuantao HAO
Chinese Journal of Epidemiology 2019;40(10):1262-1268
Objective:
To evaluate the burden and to describe the characteristics of spatial distribution caused by malignant tumors among different administrative areas in Guangzhou from 2010- 2013.
Methods:
Based on data from the Cancer Registry system and population in Guangzhou in 2010- 2013, disability-adjusted life year (DALY) was assessed on the disease burden of cancer, in accordance with the method used in the Global Burden of Disease study.
Results:
The crude incidence rates of cancer appeared as 256.22/105 in 2010-2011 and 270.04/105 in 2012-2013, with the crude mortality rates as 143.17/105 and 148.01/105, respectively, in Guangzhou. Cancers caused 606 238.95 DALYs in 2010-2011 and 623 763.80 DALYs in 2012-2013 for both sexes and 37.63 and 37.81 person year per 1 000 persons, with the standardized DALY rates as 34.51‰, 34.00‰ respectively. Three administrative districts (Yuexiu, Haizhu and Liwan) were with the largest disease burden of cancers that accounted for 45