1.Effects of Different Processing on the Contents of Paeono1 and Paeoniflolin in Cortex Moutan
Zhichun QIU ; Dongmei SUN ; Chengguang ZHANG
Journal of Medical Research 2006;0(04):-
Objective A HPLC method was established for the determination of paeonol and paeoniflolin in cortex moutan from different processing.To investigate the necessity of processing to the cortex moutan.Methods The HPLC(high performance liquid chromatogram)method was established for the determination of the contents of the paeonol and paeoniflolin in cortex moutan.The conditions of the chromatograph method was as following:AC18 column was used.The mobile phase for paeonol determination was methanol-water(45:55)and detection wavelength was 274nm.The mobile phase for paeoniflorin determ ination was acetonitrile-0.1%H3PO4(15:85)and detection wavelength was 230nm.Results The results showd that the linear ranges of paeonol and paeoniflorin determ ination were 0.36~2.2?g/L~and 0.042~1.06?g/L respectively.The average recoveries of paeonol and paeoniflorin were 96.30%(RSD=0.97%)and 98.21%(RSD=0.64%)respectively.Conclusion The method is simple,accurate and reproducibility.The experimental results showd that the contents of paeonol and paeoniflorin in coaex moutan from diferent processing were positive correlated,while the contents of cortex moutan from Sichuan were higher than that of the others.We had better combine the pharmacodynamic action study to illuminate the feasibility of processing to the Cortex Moutan.
2.Comparison of surgical clipping and intravascular interventional therapy in treatment of intracranial wide-necked aneurysm
Qingrong FAN ; Enren WANG ; Lie ZHANG ; Zhichun QIU ; Mingjie HE
Chinese Journal of Postgraduates of Medicine 2014;37(20):16-19
Objective To compare the clinical effects and safety of surgical clipping and intravascular interventional therapy in treatment of intracranial wide-necked aneurysm.Methods The clinical data of 158 patients with intracranial wide-necked aneurysm from February 2010 to February 2013 were retrospectively analyzed,all patients were divided into two groups:surgical clipping group with 92 cases and intravascular interventional therapy group with 66 cases,the postoperative curative effects,treatment time,hospital stay,hospital expenses and postoperative complications between two groups were compared.Followed up for 10-46 months,the recurrence rate were compared.Results The good prognosis and defective rates between surgical clipping group and intravasular interventional therapy group had no significant difference [90.2%(83/92) vs.90.9%(60/66),9.8%(9/92) vs.9.1% (6/66)] (x2 =0.298,P > 0.05).The preoperative Hunt-Hess classification and CT Fisher classification between two groups had no significant difference (P > 0.05).Six months after discharge,mRS score was used to evaluate the curative effect,the defective rates in same level patients between two kinds of treatment methods had no significantdifference (P > 0.05).The treatment time,hospital stay in surgical clipping group were significantly longer than those in intravascular interventional therapy group [(4.03 ± 1.01) h vs.(1.61 ± 0.98) h,(15.90 ± 2.03) dvs.(13.20 ± 1.95) d],hospital expenses was significantly lower than that in intravascular intervention therapy group [61 829.4 ±320.6) yuan vs.(99 876.2 ±371.5) yuan] (P <0.05).The postoperative complications rate between two groups had no significant difference (P > 0.05).Followed up for 31.3 (10-46) months,the recurrence rate in surgical clipping group was significantly lower than that in intravascular intervention therapy group [1.1% (1/94) vs.8.8% (6/68)] (P < 0.05).Conclusion Surgical clipping and intravascular interventional therapy in treatment of intracranial wide-necked aneurysm has their own different characteristics,so patients' treatment methods should be based on their preoperative status (especially preoperative Hunt-Hess and Fisher classification) and patients' economic conditions.
3.Clinical observation of using surgery to treat hypertensive intracerebral hemorrhage (HICH) patients
Qingrong FAN ; Enren WANG ; Lie ZHANG ; Zhichun QIU ; Mingjie HE ; Gang HUO
Chinese Journal of Primary Medicine and Pharmacy 2014;(16):2463-2465
Objective To discuss the clinical effects of using CT positioning keyhole approach to treat hy-pertensive intracerebral hemorrhage (HICH).Methods 85 cases of patients with hypertensive intracerebral hemor-rhage(HICH) were chosen and divided into two groups according to the operation methods:the observation group had 55 cases given CT positioning keyhole approach ,while the control group had 30 cases treated with traditional cranioto-my hematoma removal operation .All patients were supplemented by postoperative blood pressure control and nutrition -al support treatment .The average operation time ,hematoma disappearing time ,the length of hospital stay and re-bleed-ing rates and postoperative ability of daily life ( ADL) scores of the two groups were all carefully recorded and com-pared.Results The average operation time,hematoma disappearing time and hospital stay of the observation group were (66.5 ±12.8)min,(3.4 ±1.3)d,and (9.3 ±1.7)day which were all significantly lower than those of the con-trol group(193.5 ±23.7)min,(5.8 ±2.1)d and (15.2 ±3.8)d;T-test values of the two groups were 2.874,3.125 and 3.433 separately(P<0.05);there were 2 cases(3.6%) of postoperative hemorrhage in the observation group of while 6 cases(20.0%) in the control group,whose difference was statistically significant (χ2 =6.097,P<0.05);In the observation group 4 cases(7.3%) died after operation and also 4 cases(13.3%) died in the control group ,and the mortality of the two groups had no statistical significance (χ2 =0.836,P>0.05).6 months′follow-up after opera-tion,in the control group 2 cases were lost to follow-up while in the observation group 3 cases were lost to follow-up;Using ADL to evaluate the two groups of patients with survival and continuous follow-up,we found that the observation group′s postoperative quality of life was better than that of the control group′s(μ=3.325,P<0.05).Conclusion Using CT positioning keyhole approach has smaller trauma , shorter operation time and faster postoperative recovery and other characteristics,which is an effective method for the treatment of hypertensive intracerebral hemorrhage(HICH).
4. Impact of hypertensive disorder complicating pregnancy on neonatal mortality and major complications in preterm infants
Meiyu WANG ; Xiangyong KONG ; Zhichun FENG ; Fengdan XU ; Hongyan LYU ; Lihong YANG ; Sujing WU ; Rong JU ; Jin WANG ; Li PENG ; Zhankui LI ; Xiaolin ZHAO ; Shujuan ZENG ; Huixian QIU ; Weixi WEN ; Hui WU ; Ying LI ; Nan LI ; Xuefeng ZHANG ; Wenzheng JIA ; Guo GUO ; Weipeng LIU ; Feng WANG ; Gaimei LI ; Fang LIU ; Wei LI ; Xiao-ying ZHAO ; Hongbin CHENG ; Yunbo XU ; Wenchao CHEN ; Huan YIN ; Yanjie DING ; Xiaoliang WANG ; Ruiyan SHAN ; Ping XU ; Meiying HAN ; Chunyan YANG ; Tieqiang CHEN ; Xiaomei TONG ; Shaojun LIU ; Ziyuan LIU
Chinese Journal of Applied Clinical Pediatrics 2018;33(14):1065-1070
Objective:
To investigate the effect of hypertensive disorder complicating pregnancy (HDCP) on the mortality and early complications of premature infants.
Methods:
The general clinical data of preterm infants with gestational age 24-36+ 6 weeks were collected from the cooperative units in the task group from January 1, 2013 to December 31, 2014.According to the severity of HDCP, the infants were divided into 4 groups: HDCP group, preeclampsia group, eclampsia group and non HDCP group, the mortality and major complications of preterm infants were compared, and the influencing factors were analyzed.
Results:
The mortality rate of preterm in the HDCP group was significantly higher than that of non HDCP group, and there was statistical significance (