1.Effects of procainamide on ventricular fibrillation in a canine model of sudden coronary death
Chinese Journal of Pathophysiology 1986;0(03):-
A canine model of sudden coronary death was established by intimal sur-face anodal direct current stimulation of the left circumflex coronary artery (LCX)on 5-8 days after the left anterior descending coronary artery (LAD) infarction. TheLCX intimal injury and subsequent thrombus formation produced ECG ST segment chan-ges at 104?30 minutes (X?SD), followed by premature ventricular beats, ventriculartachycardia (VT), and ventricular fibrillation (VF) in all normal saline (NS) treated dogs(n=6), in procainamide (PA) treated dogs (n=6), ECG ST segment changes appearedat 110?40 minutes, followed by VT and VF in only one dog (P
2.Reliability and validity of stress vulnerability prediction scale in soldiers
Jieqiong GUO ; Zhibing YANG ; Xia ZHU
Chinese Journal of Behavioral Medicine and Brain Science 2013;(1):72-74
Objective To develop stress vulnerability prediction scale for soldiers.Methods 148 items were determined by reviewing items in relating literatures and scales,interview,panel discussion and expert consultation.Then 431 and 351 soldiers in two times were picked out randomly as samples from Army Northwest District.Item analysis,exploratory factor analysis,reliability analysis and confirmatory factor analysis were used to analyse the data.Results Stress vulnerability prediction scale comprised five subscales:traumatic events,positive affect,negative trait,negative coping and interpersonal support.The scale was comprised of 59 items,and the factor loading of the items ranged from 0.503 to 0.839.Cronbach's α coefficient of the five subscales were 0.777,0.903,0.923,0.882,0.908,and the Cronbach's α coefficient of the scale was 0.895.Confirmatory factor analysis showed a higher goodness of fit(RESEA =0.058,NFI =0.89,NNFI =0.93,CFI =0.94,IFI =0.98).Conclusion Stress vulnerability prediction scale in soldiers has good psychometric properties,and can be used as a prediction measurement tool for measuring the stress disorder for soldiers.
3.Percutaneous Nephrolithotomy Combined with Pneumatic and Ultrasonic Lithotripsy for Complex Renal Calculi:Report of 150 Cases
Jianming GUO ; Guomin WANG ; Zhibing XU
Chinese Journal of Minimally Invasive Surgery 2005;0(10):-
Objective To evaluate the clinical efficacy of percutaneous nephrolithotomy (PNL) in combination with pneumatic and ultrasonic lithotripsy in the treatment of complex renal calculi. Methods Under general anesthesia,an ureteral stent was placed into the patient by cystoscopy. With the prone position,percutaneous access was established by inserting an access needle into the intended calix under the guidance of ultrasonography or fluoroscopy. Afterwards,combined pneumatic and ultrasonic probes were used by nephroscopy for lithotripsy. Results A single tract was used in 137 patients,while two or three tracts were created in the other patients (11 and 2 respectively). One-step procedure to remove the stones was achieved in 119 patients,while a second intervention was performed in 27,and three procedures was carried out in 4. The mean time of the operations were (88?34) min. After the operation,one patient developed infectious shock,and then was cured by anti-shock therapy;two patients showed secondary hemorrhage in two weeks postoperation,and was cured by conservative therapy. In this series,the rate of stone clearance was 84.7% (127/150);23 cases had residual stones,10 of them received ESWL (the stone was removed completely in 7 of the 10 cases),and the other 13 were treated by oral medicines. Six months after the operation,follow-up examination showed a stone-free rate of 89.3% (134/150). Conclusion Combination of ultrasonic and pneumatic intracorporeal lithotripsy is effective and safe for complex renal calculi,which is intractable by open surgery.
4.Efficacy and safety of tolterodine on late-onset overactive bladder symptoms after prostate brachytherapy
Yanjun ZHU ; Zhibing XU ; Guomin WANG ; Yeqing XU ; Jianming GUO
Chinese Journal of Urology 2012;33(9):660-663
Objective To assess the efficacy and safety of tolterodine on late-onset overactive bladder symptoms after prostate brachytherapy due to prostate carcinoma.Methods Twenty-six prostate cancer patients diagnosed by biopsy,who underwent prostate brachytherapy using iodine-125,were recrui(t)ed in this trial.All cascs complained of overactive bladder symptoms 6 months postoperatively.The 26 patients were divided into 2 groups:14 men in tolterodine group (TR group) who were given tolterodine 2 mg twice a day; 12 men in tamsulosin group (TS group) who were given tamsulosin 0.2 mg once a day.Efficacy was assessed by changes in IPSS,OABSS and nighttime voiding at 2 weeks and 4 weeks after medical treatment respectively.Safety was assessed by postvoid residual (PVR) and acute urinary retention (AUR),dry mouth,constipation and tachycardia at the fourth week after medical treatment.Results The age,tumor staging,GS,PSA,initial prostate volume,IPSS,OABSS,nighttime voiding,iodine-125 seeds implanted and needles punctured of both groups were comparable.IPSS,OABSS and nighttime voiding were significantly improved in TR group after 2 weeks of medical treatment and the above parameters were significantly improved than TS group (14.4 vs 18.3,5.9 vs8.4,1.4 vs2.5).OAB symptoms of TR group were also significantly improved than TS group after 4 weeks of therapy.There were no significant differences of PVR and AUR,dry mouth,constipation and tachycardia between both groups.Conclusions Tolterodine is effective and safe in treating late-onset OAB symptoms after prostate brachytherapy,although the occurence of dry mouth and tachycardia might be increased.
5.Reliability and validity of idol worship scale in college students
Zhibing YANG ; Jieqiong GUO ; Liang XIA ; Xia ZHU
Chinese Journal of Behavioral Medicine and Brain Science 2012;21(1):89-91
ObjectiveTo develop the scale on idol worship for college students.Methods54 items were determined by reviewing items in relating literatures and scales,interview and panel discussion.Then about 110,182 and 277college students were picked out randomly as samples from colleges of Guangzhou.Item analysis,exploratory factor analysis,reliability analysis and confirmatory factor analysis were used to analyse the data.ResuitsIdol worship scale comprised four subscales:fascination,rational knowledge,the degree of concern and behavioral modification.The scale was comprised of 20 items,and the factor loading of the items ranged from 0.552 to 0.841.Cronbach's α coefficient of the four subscales were 0.894,0.715,0.769,0.758,and the Cronbach's α coefficient of the scale was 0.889.Confirmatory factor analysis showed a higher goodness of fit( RESEA =0.064,GFI =0.89,NFI =0.96,NNFI =0.98,CFI =0.98,IFI =0.98 ).ConclusionThe idol worship scale has good psychometric properties,and can be used as a measurement tool for measuring the idol worship of college students.
6.Correlation of metabolic syndrome with recurrence of urolithiasis
Xing CHEN ; Jianming GUO ; Guomin WANG ; Zhibing XU ; Hang WANG
Chinese Journal of Urology 2015;36(8):624-627
Objective To investigate the relationship between metabolic syndrome (MS) and recurrence of urolithiasis.Methods A retrospective analysis was performed in urinary stone patients from March 2008 to February 2012.Patients were divided into MS group and non-MS group according to the diagnose criteria of metabolic syndrome (2007 version) by the joint committee for developing Chinese guidelines on prevention and treatment of dyslipidemia in adults.The patients were followed up for 24-72months (median 47 months) since operation.The difference of stone recurrence was compared between the 2 groups.Results Two hundred and eighteen patients with urinary stone disease were enrolled.Of them,52 patients were diagnosed with MS.Stone recurrence occurred in 29 patients (55.8%) of MS group,whereas 66 patients (39.8%) of non-MS group suffered stone recurrence.It demonstrated the median recurrence free survival of group MS and non-MS was 36 months and 59 months by Kaplan-Meier analysis,respectively (Log-rank test,P =0.019).Multivariate Cox regression analysis results revealed that MS was significantly associated with stone recurrence (HR 1.817,95% CI 1.105-2.988,P =0.011),however,the gender (P =0.336),age (P =0.246) and recurrence urolithiasis at first visit (P =0.051) were not associated with stone recurrence.Conclusions MS is an independent risk factor for urinary stone recurrence.It is suggested that the treatment of MS may have a important role in prevention of stone recurrence in MS patients with urolithiasis.
7.Effects of procainamide on a canine model of electropharmacology as assessed by programmed electrical stimulation
Zhibing GUO ; Hongyu CAO ; Zhi XU ; Qing LI
Chinese Pharmacological Bulletin 1986;0(05):-
A canine model of electro-physiologic-electropharmacologic testing on ischemic ventricular tachyarrhythmias were established in the open-chest dogs subjected to programmed electrical stimulation (PES) on 5~8days after acute my-ocardial infarction produced with two -stage occlusion of left anteriol decending coronary artery (LAD) followed by partly reperfusion. The electrophysiologic -electropharmacologic effects of pro-cainamide (PA ) were observed in this canine model. pA distinctly lengthened the QTc interval and the effective refractory period ( ERP) of normal and infarct myocardium in both ventricles and decreasedthe dispersion of ERP in infarct myocardium (IDR) as well as the dispersion of ERP in left ventricle (VDR). The PES - induced ventricular tachycardia (VT) or ventricular fibrillation (VF) was prevented in 5 out of 6 PA treated dogs (n = 6),Normal saline (NS) did not prevented PES- induced VT/VF. The results suggest that PA may be effective in preventing the onset of reentrant ventricular tachyarrhythmias after myocardium ischemic damage.
8.Application of combined osteotomy with midfacial SMAS lift in comprehensive correction of facial shape
Qiang ZHANG ; Jun GUO ; Zhibing MENG ; Caiwang CHANG ; Le YANG ; Jinhua HUANG
Chinese Journal of Medical Aesthetics and Cosmetology 2013;(2):83-85
Objective To observe the surgical results of prominent malar-complex and to explore the more effective methods by improving the shape of face through operation.Methods Total 80 patients of prominent malar-complex were treated by strengthening reduction plasty of mala and zygoma through intra-oral approach accompanied with minor pre-auricular incision and the midfacial SMAS lift in order to improve the shape of prominent malar-complex and to prevent malar-cheek parenchyma sag.Results The face skeleton and midfacial chalasis of all patients were significantly improved with satisfaction.All the patients obtained good results during the follow-up period of over six months.Of them there was one case of maxillary sinusitis that had been cured by further symptomatic treatment.Conclusions Strengthening reduction plasty of mala and zygoma accompanied with the midfacialSMAS lift can properly and safely improve the facial shape of patients with prominent malar-complex.
9.Analysis on Medical Records of Huang Chunlin for Characteristics of Chronic Kidney Disease Treatment by Data Mining Method
Xiaoxuan HU ; La ZHANG ; Zhibing LI ; Xinfeng GUO ; Chuan ZOU ; Xusheng LIU
World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(5):969-974
This study was aimed to analyze the formulas and classify the treatment of chronic kidney disease (CKD) by Dr. Huang Chunlin based on the data mining method. A total of 63 CKD outpatients' medical records by Dr. Huang were collected. And 226 formulas prescribed in the medical records were put in the Traditional Chinese Medicine Inheritance Support System (TCMISS). Data mining techniques were applied in the study of as-sociation rule mining algorithm and complex system entropy cluster, the usage frequency and the correlation of each single Chinese medicinal in order to sort out the prescription pattern of CKD. The results showed that to for-tify the spleen and tonify the kidney were found to be the basic method of CKD treatment . Through the applica-tion of TCMISS, the Chinese medicinals used in Dr. Huang's CKD treatment were Astragalus root, Eucommia, Epimedium, Cuscuta, Agastache, Danshen Root, Ligustrum. It was concluded that the TCMISS is of great value in the summarization of clinical experiences of well-known TCM doctors.
10.Comparison of outcomes in laparoscopic radical prostatectomy and open radical prostatectomy
Yiwei WANG ; Hang WANG ; Zhibing XU ; Li'an SUN ; Zongming LIN ; Guomin WANG ; Jianming GUO
Chinese Journal of Urology 2015;36(8):592-594
Objective To compare outcomes of laparoscopic radical prostatectomy (LRP) and open radical prostatectomy (ORP) performed in our hospital.Methods A non-randomized,retrospective comparative study was performed to analysis 302 prostate cancer patients from January 2011 to June 2014.One hundred and ten patients underwent LRP and 192 underwent ORP.There were no significant differences between the LRP and ORP groups with respect to patient age,body mass index,PSA level,Gleason Score,clinical T stage and transrectal ultrasonography prostate volume (P > 0.05).The operating time,estimated blood loss,catheter retaining time,hospital stay time,positive surgical margin rate and urinary control rate were compared between the 2 groups.Results The median operative time of the ORP group and the LRP group was 95 min and 120 min,the difference between groups was significant (P < 0.01).The median duration of hospitalization of the 2 groups was 9 d and 6 d,the difference between groups was significant (P<0.01).ORP group and LRP group's estimated blood loss was 350 ml and 250 ml.Days of tube drainage were 3 d in both groups.Days of urinary catheterization drainage after surgery were 16 d and 15 d,respectively.Positive margin rate was 10.4% and 12.7%.Urinary continence recovery rates at 3 month were 80.2% and 70.8%.Urinary continence recovery rates at 6 month were 85.9% and 87.3%.No significant difference was observed in the above index (P > 0.05).Conclusions Compared with ORP,LRP has shorter hospital stay time and longer operating time.Both LRP and ORP have good outcomes in oncological control and function rehabilitation.Both of them are important procedures to treat localized prostate cancer.