1.Ureteroscopy Combined with ESWL for Ureteral Calculus:Report of 256 Cases
Sanwei WANG ; Zhian JING ; Changshuan LI
Chinese Journal of Minimally Invasive Surgery 2005;0(10):-
Objective To investigate the clinical value of ureteroscopy combined with ESWL for the treatment of ureteral stone.Methods From October 2005 to June 2007,a total of 256 patients with ureteral stones were treated in our hospital.The calculus in the middle and lower ureter were removed by ureteroscopy,while the stones in the upper ureter was treated by ESWL.For the cases that failed ureteroscopy or those who had residual stones after the treatment,ESWL was performed as a supplement.ResultsIn the patients with lower ureteral stones,the one-stage cure rate was 98.2%(167/170),while in those with middle and upper ureteral calculi,the rate was 89.2%(50/56) and 73.3%(22/30) respectively.Three patients developed perforation of the ureter during the surgery,and one had mucosal injury of the ureter.One case was converted to open surgery because of perforation of the ureter resulted from ureteral twist.Twelve patients were failed ureteroscopy or had residual stones,and received ESWL as the second-stage treatment,11(91.7%) of them were cured afterwards.Conclusions Ureteroscopy is effective for middle and lower ureteral stones.For the cases failed the operation or have residual calculi,ESWL is a good choice.
2.The effect of local nitroglycerine application via the angiography catheter on prevention of radial artery spasm
Tao CHEN ; Jing GUO ; Chunxia ZHOU ; Zhian JIANG
Chinese Journal of Interventional Cardiology 2014;(6):369-371
Objective This study aimed to study the effect of intra-brachial nitroglycerin administration via the angiography catheter on radial artery spasm in transradial percutaneous coronary intervention. Methods From patients undergoing transradial percutaneous coronary intervention (TRI) and succeeding in coronary angiography (CAG), 810 patients who needed percutaneous coronary intervention (PCI) (including Percutaneous Transluminal Coronary Angioplasty and/or stent implantation) were erolled, including 413 patients in the study group and 397 patients in the control group. When coronary angiography completed, positioned the angiography catheter over brachial artery and patients in the group received an administration of 400μg nitroglycerin via the angiography catheter. The control group received an administration of 400μg nitroglycerin via the sheath. The incidence of RAS were recored and compared. Resultes Baseline characteristics were similar between two groups. In the study group, the incidence of RAS was signiifcatively lower (18 vs. 33, P=0.021). Conclusions Intra-brachial nitroglycerin administration via the angiography catheter can prevent RAS during the insertion of guiding catheter in TRI.
3.The association between hyperuricemia and prevalence of carotid plaque
Yan LI ; Dong ZHAO ; Jing LIU ; Zhian LI ; Qiang YONG ; Wei WANG
Chinese Journal of Internal Medicine 2008;47(11):906-909
Objective To analyze the association of hyperuricemia with incidence of carotid plaque in general population and furthermore to explore the predictive value of serum uric acid in the early prevention of atherusclerotic disease. Methods The participants were selected from a part of Chinese Multiprovincial Cohort Study (CMCS). Two investigations on cardiovascular risk factors and two on carotid ultrasound detection were carried out in 2002 and 2007, respectively. Results (1) The standard prevalence of hyperurieemia on baseline was 5.4%, being 7.7% in male and 3.9% in female. (2) The standard incidence of carotid plaque was 45.3%, being 51.7% in male and 42. 7% in female. It was shown that the incidence of plaque in the bulb of common carotid arteries was the highest. (3) After adjusting for age, smoking, high triglyceride, high cholesterol, hypertension, diabetes, overweight and obesity,hyperurieemia in female was an independent risk factor associated with 5-year incidence of formation plaque in the bulb of common carotid; the odds ratio (OR) was 3.56 (P = 0.02, 95% CI = 1.21-10. 41).Conclusion Hyperuricemia in female was an independent risk factor associated with 5-year incidence of plaque formation in the bulb of common carotid, and hyperuricemia in male was not an independent factor associated with 5-year incidence plaque formation.
4.Effect of compound prescription cortex phellodendri chinensis fluid on postoperative wound anastomosis nail loss in patients with circumcision by disposable circumcision suture device
Lei LIU ; Zhian JING ; Yanjun LIU ; Jihua LI ; Zhanqi FENG ; Heping HU
Chinese Journal of Biochemical Pharmaceutics 2015;(9):88-90
Objective To discuss cause and treatment measures of the postoperative failed to fully automatic nail in patients with circumcision by disposable circumcision suture device, so as to improve the quality of the circumcision.Methods 182 cases received circumcision by disposable circumcision suture device were randomly selected from September 2014 to March 2015 in the hospital and divided into control group ( n =86 ) and treatment group (n=96).All the patients received oral antibiotics for three days conventionally.Patients in control group were dressing with 0.1%iodine after treatment, dressing change every two or three days, while the treatment group soaking with 30 mL to 40 mL compound prescription cortex phellodendri chinensis fluid for 15 min two times per day.The postoperative wound anastomosis nail loss effect in two groups were compared.Results The time of complete nail loss in patients soaking with compound prescription cortex phellodendri chinensis fluid was significantly shorter than that in patients dressing with 0.1% iodine (P<0.05), but there was no significantly difference of the first time to lose nail between two groups.The rate of complete nail loss in treatment group was 94 cases (97.9%), which was significantly higher than 68 cases (79.1%) in control group (χ2 =16.47,P<0.05). The adverse reactions were mild of two groups.Conclusion The compound prescription cortex phellodendri chinensis fluid has exact effect on postoperative wound anastomosis nail loss and recovery in patients’ with circumcision by disposable circumcision suture device.
5.The analysis of complications and prevention treatment circumcision with disposable circumcision suture device
Zhian JING ; Yanjun LIU ; Jihua LI ; Heping HU
China Modern Doctor 2014;(20):115-117
Objective To discuss the cause of the postoperative complications, prevention and treatment measures of circumcision with disposable circumcision suture device, so as to reduce the incidence of postoperative complications, further improve the quality of the circumcision. Methods A total of 111 patients undergoing circumcision with dispos-able circumcision suture device were included. Complications and the satisfaction of the post-operative appearance were evaluated. Results The total rate of postoperative complications was 8.1%(9/111). The complications were infec-tion 1.8%(2/111),bleeding 6.3%(7/111),without wound dehiscence and penile edema. Conclusion Circumcision with disposable circumcision suture device has the advantages of fewer complications, and higher satisfied postoperative ap-pearance of the penile. Most of the complications can be treated with conservative management.
6.Association of SPO11 and GST gene polymorphisms with idiopathic male infertility in ethnic Han Chinese.
Zhanqi FENG ; Zhian JING ; Hongyan LIU ; Shixiu LIAO ; Liangjie GUO ; Changqing MAO ; Yanjun LIU ; Hui WU ; Jiangtao GAO
Chinese Journal of Medical Genetics 2015;32(6):866-870
OBJECTIVETo explore the possible roles of polymorphisms of SPO11 and glutathionine S-transferase (GST) genes in idiopathic male infertility in a ethnic Han Chinese population from Henan.
METHODSMultiplex PCR and DNA sequencing were performed to determine the SPO11 c.517C>T(rs28368082) and GST genes (GSTM1, GSTT1, GSTP1) polymorphisms in 216 idiopathic male infertility cases and 198 normal samples.
RESULTSThe frequencies of the SPO11 CC and CT genotypes were 87.5% (189/216) and 12.5% (27/216) in the patients, and 97.5% (193/198) and 2.5% (5/198) in the controls, respectively. The frequencies of SPO11 CC and CT genotypes, the A>G transition at nucleotide 313 in the exon 5 of the GSTP1 gene, and the frequencies of combined genotypes GSTM1 (-/-), GSTT1 (+/+), GSTP1 (AA) and SPO11 (CT) were significantly different between the two groups (P<0.05).
CONCLUSIONThe rs28368082 polymorphism of the SPO11 gene, the A>G transition at nucleotide 313 in the exon 5 of the GSTP1 gene, and the combined genotypes of GSTM1 (-/-), GSTT1 (+/+), GSTP1 (AA) and SPO11 (CT) may be associated with idiopathic male infertility in ethnic Han Chinese.
Adult ; Alleles ; Asian Continental Ancestry Group ; genetics ; Base Sequence ; China ; Endodeoxyribonucleases ; genetics ; Gene Frequency ; Genetic Predisposition to Disease ; ethnology ; genetics ; Genotype ; Glutathione S-Transferase pi ; genetics ; Glutathione Transferase ; genetics ; Humans ; Infertility, Male ; enzymology ; ethnology ; genetics ; Linkage Disequilibrium ; Male ; Mutation ; Odds Ratio ; Polymorphism, Genetic ; Sequence Analysis, DNA
7.Application of array comparative genomic hybridization in prenatal diagnosis of a case with 5q35 deletion syndrome.
Zhanqi FENG ; Heping HU ; Changqing MAO ; Dingzhan WANG ; Lei LIU ; Shiling LIU ; Zhian JING ; Hongyan LIU
Chinese Journal of Medical Genetics 2017;34(2):240-243
OBJECTIVETo use combined G-banding and array-comparative genomic hybridization (aCGH) for the prenatal diagnosis of a fetus with 5q35 deletion syndrome.
METHODSChromosomal karotypes of the fetus and parents were analyzed with G-banding analysis. aCGH was performed to detect minor chromosomal structural abnormalities.
RESULTSThe karyotype of the fetus was ascertained as 46, XY, t(5;10)(q35;p13), and the karyotypes of the parents were normal. aCGH has identified a de novo 1.68 Mb deletion at 5q35.2q35.3 and a 1.44 Mb duplication at 10p14p13.
CONCLUSIONaCGH has a higher resolution and greater accuracy for mapping chromosomal aberrations and is a useful supplement for G banding karyptyping analysis.
Adult ; Chromosome Banding ; Chromosome Deletion ; Chromosomes, Human, Pair 5 ; genetics ; Comparative Genomic Hybridization ; Cri-du-Chat Syndrome ; diagnosis ; embryology ; genetics ; Female ; Fetal Diseases ; diagnosis ; genetics ; Humans ; Karyotyping ; Male ; Prenatal Diagnosis ; Trisomy ; diagnosis ; genetics
8.Analysis of diagnosis and treatment of Lesch-Nyhan syndrome
Zhanqi FENG ; Liangjie GUO ; Zhian JING ; Hailan XIA ; Songlin CHEN ; Junxiang SU ; Hongdan WANG
Chinese Journal of Urology 2021;42(12):919-924
Objective:To explore the etiology, clinical diagnosis and treatment strategy of Lesch Nyhan syndrome.Methods:We retrospectively analyzed 2 patients with severe dyskinesia, mental retardation and complicated renal calculi who were admitted to the first people's Hospital of Zhengzhou in August 2019. Case 1, male, 9 years old, had multiple urinary calculi for 1 year. The patient came to the local hospital because double multiple kidney stones and bladder stonesa year ago. The patient had been treated with transurethral holmium laser lithotripsy for bladder stones. The results of infrared spectrum showed that the bladder stone was anhydrous uric acid stone. A week ago, color Doppler ultrasound showed multiple kidney stones and bladder stones. The patient was underdeveloped, mentally retarded and had a full-term cesarean section. There was no history of hypoxia, asphyxia and rescue of the patient. He had the following clinical manifestations: In the waking state, he was no language response to any stimulation. The nasolabial fold on the right was shallow and the corner of the mouth was oblique to the left. He lost the large movements such as lifting head, sitting alone, standing. The trunk showed torsion spasticity, limb muscle strength 2-3, limbs showing spastic hypertonia, limb joints stiff, hands showing fist-like, no involuntary movement and muscle fasciculation. The biceps reflex and knee tendon reflex were not elicited, and the pathological reflex was positive. Serum uric acid was 517 μmol/L. The Case 2 came from the same family, male, 6 years old, had the similar symptoms to his elder brother case 1. The family members complained on behalf of the child about intermittent fever for more than 2 years. The imaging examination of case 2 revealed kidney stones. Serum uric acid was 373 μmol/L. Whole Exome Sequencing and Sanger Sequencing were used to find the genetic causes of the two siblings. The NCBI-Homologene database was used to find the homologous sequence of the human HPRT1 gene, and the human HPRT1 gene sequence was compared with other species to analyze the protein conservation. The online website PredictProtein (http: //www.predactprotein) was used to predict the two-dimensional structure of the HPRT1 gene. The reported cases were summarized and same with the treatment plan.Results:A De novo mutation [c.571T>G(p.Tyr191Asp)] was found in the HPRT1 gene of the child, which was inherited from the mother. Lesch Nyhan syndrome can be diagnosed by the results of gene examination combined with clinical manifestations. The amino acid Tyr at the 191 position and the amino acids before and after it were highly conserved. Amino acid 191 was involved in the β-strand of the protein. We treated the patients with the lowest dose of allopurinol and children's conventional dose of potassium sodium bicitrate granules, and low purine diet. After 3 months of treatment, the serum uric acid was decreased, and the urinary calculi did not increase significantly.Conclusions:Combining with the clinical manifestations of children, HPRT1 gene might be the cause of pediatric disease and the two siblings could be diagnosed as Lesch-Nyhan syndrome. For such patients, the lowest dose of allopurinol and children's conventional dose of potassium sodium hydrogen citrate granule combined with diet could be more effective.
9.Effects of SARS-CoV-2 on male reproductive system and sexual health
Miaomiao SUN ; Jing DING ; Qiang LYU ; Zhian TANG
Journal of Modern Urology 2023;28(11):1002-1006
SARS-CoV-2 may have potential effects on the male reproductive system. Evidence has shown that SARS-CoV-2 is not likely to transmit through sexual intercouse. However, male infected with SARS-CoV-2 may experience sexual dysfunction, semen quality decline, testicular damage and abnormal sex hormones. The extent and duration of these damages are still unclear, and further multidimensional research is necessary.