1.Effects of chronic hypoxic hypercapnia on spatial learning-memory and expression of NMDAR1 in rats.
Song-fang CHEN ; Sheng-min SHAO ; Zhi-pen WU ; Han-jin HUANG ; Xiao-tong WANG ; Li-yong ; Yong-sheng GONG ; Guo-qing ZHENG
Chinese Journal of Applied Physiology 2007;23(4):434-437
AIMTo explore the effect of chronic hypoxic hypercapnia on learning-memory and the possible mechanisms involved.
METHODSFifty-eight male SD rats were randomly divided into three groups: Normal control group (NC, n=18), 2-week (2HH, n=18), and 4-week hypoxic hypercapnia (4HH, n=20) group. The rats, spatial learning-memory tasks were assessed by the Morris water maze. The expression of NMDAR1mRNA was determined by hybridization in situ.
RESULTSCompared with NC group, rats exposed to chronic hypoxic hypercapnia displayed significant impairment in their performance assessed by two measures: mean escape latencies (2HH: 38.59 +/- 8.35 s, 4HH: 60.59 +/- 17.28 s) and swim path distances(2HH: 9893.45 +/- 1958.16 mm, 4HH: 18077.57 +/- 6878.85 mm). The expression level of NMDAR1mRNA in the hippocampus and cortex were lower than those in the NC group, especially, the NMDAR1mRNA expression of hippocampus CA1 in 4HH decreased by 21.4% (P < 0.01).
CONCLUSIONChronic hypoxic hypercapnia could impair the rat spatial learning-memory and the decrease in expression of NMDAR1mRNA might be involved in.
Animals ; Hypercapnia ; metabolism ; Hypoxia ; metabolism ; Male ; Maze Learning ; Memory ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate ; metabolism
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